A5100395189- Neurological Disease Mechanisms and Treatments
- Ginkgo biloba and Cashew Applications
- Bioinformatics and Genomic Networks
- Neuroinflammation and Neurodegeneration Mechanisms
- Renal Diseases and Glomerulopathies
- RNA modifications and cancer
- Pancreatic function and diabetes
- Birth, Development, and Health
- Chronic Kidney Disease and Diabetes
- Single-cell and spatial transcriptomics
- Alzheimer's disease research and treatments
- Immune Response and Inflammation
- Gene expression and cancer classification
- Tissue Engineering and Regenerative Medicine
- Cancer-related molecular mechanisms research
- Renal and related cancers
- Mitochondrial Function and Pathology
- Microbial Metabolic Engineering and Bioproduction
- Metabolomics and Mass Spectrometry Studies
- Cancer Immunotherapy and Biomarkers
- Cellular transport and secretion
- Liver physiology and pathology
- Acute Kidney Injury Research
- PARP inhibition in cancer therapy
- Natural Compounds in Disease Treatment
Shanghai Jiao Tong University
2021-2025
Shanghai Children's Medical Center
2025
Chinese University of Hong Kong
2018-2024
Nanjing Medical University
2024
University of Washington
2013-2023
Seattle University
2022
Jiamusi University
2020
Weifang Medical University
2005-2019
Oregon Health & Science University
2016
University of Portland
2015
Human tissues perform diverse metabolic functions. Mapping out these tissue-specific functions in genome-scale models will advance our understanding of the basis various physiological and pathological processes. The global knowledgebase categorized for human genome (Human Recon 1) coupled with abundant high-throughput data now makes possible reconstruction models. However, number available remains incomplete compared large diversity tissues.We developed a method called Context-specificity...
Loss of the Sortilin-related receptor 1 (SORL1) gene seems to act as a causal event for Alzheimer's disease (AD). Recent studies have established that loss SORL1, well mutations in autosomal dominant AD genes APP and PSEN1/2, pathogenically converge by swelling early endosomes, AD's cytopathological hallmark. Acting together with retromer trafficking complex, SORL1 has been shown regulate recycling amyloid precursor protein (APP) out endosome, contributing endosomal misprocessing. We...
The rigorous characterization of distinct induced pluripotent stem cells (iPSC) derived from multiple reprogramming technologies, somatic sources, and donors is required to understand potential sources variability downstream potential. To achieve this goal, the Progenitor Cell Biology Consortium performed comprehensive experimental genomic analyses 58 iPSC ten laboratories generated using a variety genes, vectors, cells. Associated global molecular studies identified functionally informative...
Abstract A critical event during kidney organogenesis is the differentiation of podocytes, specialized epithelial cells that filter blood plasma to form urine. Podocytes derived from human pluripotent stem (hPSC-podocytes) have recently been generated in nephron-like organoids, but developmental stage these and their capacity reveal disease mechanisms remains unclear. Here, we show hPSC-podocytes phenocopy mammalian podocytes at capillary loop (CLS), recapitulating key features...
With an aging population, kidney health becomes important medical and socioeconomic factor. Kidney mechanisms are not well understood. We previously showed that podocytes isolated from aged mice exhibit increased expression of programmed cell death protein 1 (PD-1) surface receptor its 2 ligands (PD-L1 PD-L2). PDCD1 transcript with age in microdissected human glomeruli, which correlated lower estimated glomerular filtration rate higher segmental glomerulosclerosis vascular arterial...
Monocyte locomotion inhibitory factor (MLIF) is a heat-stable pentapeptide from Entamoeba histolytica . Our previous study found that MLIF protects against ischemic stroke in rats and mice exerts neuroprotection effect human neuroblastoma SH-SY5Y cells. Microglia/macrophage polarization has been proven to be vital the pathology of stroke. Nevertheless, whether able modulate microglia/macrophage remains unclear. We performed middle cerebral artery occlusion (MCAO) on C57BL/6J male induced...
Strategies to increase cellular NAD
Abstract Intrahepatic cholangiocarcinoma (ICC) is a highly aggressive cancer characterized by poor prognosis and resistance to chemotherapy. In this study, utilizing scRNA-seq, we discovered that the tetra-transmembrane protein mal, T cell differentiation 2 (MAL2), exhibited specific enrichment in ICC cells was strongly associated with prognosis. The inhibition of MAL2 effectively suppressed proliferation, invasion, migration. Transcriptomics metabolomics analyses suggested promoted lipid...
The ginkgo biloba extract EGb761 improves memory loss and cognitive impairments in patients with senile dementia. It also promotes proliferation of neural stem cells the subventricular zone Parkinson's disease model mice hippocampal young epileptic rats. However, it remains unclear whether enhances endogenous brain rats vascular In this study, a dementia was established by repeatedly clipping reperfusing bilateral common carotid arteries combination an intraperitoneal injection sodium...
Background The biomarker discovery field is replete with molecular signatures that have not translated into the clinic despite ostensibly promising performance in predicting disease phenotypes. One widely cited reason lack of classification consistency, largely due to failure maintain from study study. This attributed variability data collected for same phenotype among disparate studies, technical factors unrelated phenotypes (e.g., laboratory settings resulting "batch-effects") and...
We utilized abundant transcriptomic data for the primary classes of brain cancers to study feasibility separating all these diseases simultaneously based on molecular alone. These signatures were a new method reported herein that resulted in cancer marker panel 44 unique genes. Many genes have established relevance examined, with others having known roles biology. Analyses large-scale from multiple sources must deal significant challenges associated heterogeneity between different published...
Dioscorea nipponica Makino, a popular folk medicine, exerts anti-inflammation properties. The present study investigated the therapeutic effect of total saponins from Makino (TSDN) on aplastic anemia (AA) and possible immune regulation mechanisms. Using mouse model AA, three different doses TSDN were orally administrated for 14 consecutive days. We first demonstrated that was found to be effective in alleviating pancytopenia with hypocellular bone marrow as compared AA group. Moreover,...
Renin expressing cells in the kidney's juxta-glomeruluar compartment likely also serve as progenitors for adult glomerular disease. Although these of renin lineage (CoRL) decrease number with advancing kidney age, accompanied by less responsiveness to typical stimuli such ACE-inhibition, mechanisms and impact sex a biological variable age are not known. Accordingly, labeled CoRL were sorted from individual young (2m) aged (27m) male female Ren1cCre|ZsGreen reporter mice, their transcriptomic...
Vascularization remains an obstacle when engineering complex tissues for regeneration and disease modeling. Although progress has been made in recreating 3D vascular structures, challenges exist generating a mature, functional endothelium. It is demonstrated that perfusing engineered microvessels with platelet-rich plasma, critical homeostatic component vivo often overlooked vitro, substantially transforms the endothelium, both maturing endothelial cells improving functionality 24 h....
Abstract Single cell RNA-seq measures the transcriptomes of many types across diverse conditions. However, an emerging challenge is to uncover how different communicate with each other maintain tissue homeostasis, and inter-cellular communications are perturbed in diseases. To address this problem, we developed talklr, information theory-based approach potential ligand-receptor interactions involved homeostasis Compared existing approaches that analyze changes gene type separately, talklr...
Lung cancer is still the leading cause of cancer-related mortality worldwide. Around 80 to 85% lung cancers are non-small cell (NSCLC). Regional lymphatic metastasis a frequent occurrence in NSCLC, and extent dissemination significantly determines prognosis patients with NSCLC. Hence, identification alternative treatments for these should be considered priority. Liposomal paclitaxel new formulation composed liposomes, favorable pharmacokinetic properties. In particular, it produces...