A5100334738- Lipid metabolism and biosynthesis
- Cardiac Fibrosis and Remodeling
- Adipose Tissue and Metabolism
- Endoplasmic Reticulum Stress and Disease
- Cardiac Arrhythmias and Treatments
- Viral Infections and Immunology Research
- Atrial Fibrillation Management and Outcomes
- Antiplatelet Therapy and Cardiovascular Diseases
- Liver Disease Diagnosis and Treatment
- Signaling Pathways in Disease
- Acute Myeloid Leukemia Research
- Spine and Intervertebral Disc Pathology
- Heart Failure Treatment and Management
- Cervical and Thoracic Myelopathy
- Drug Transport and Resistance Mechanisms
- Heart Rate Variability and Autonomic Control
- Spinal Cord Injury Research
- Acute Ischemic Stroke Management
- Mitochondrial Function and Pathology
- Cholesterol and Lipid Metabolism
- RNA Research and Splicing
- Electromagnetic Fields and Biological Effects
- Cancer, Hypoxia, and Metabolism
- Plant biochemistry and biosynthesis
- Alcohol Consumption and Health Effects
First Affiliated Hospital of Bengbu Medical College
2025
Air Force Medical University
2013-2024
Xijing Hospital
2013-2024
Wuhan Sports University
2024
West China Hospital of Sichuan University
2023
Sichuan University
2023
Yuhuangding Hospital
2022
Qingdao University
2022
Peking University
2021
Wenzhou Medical University
2021
Abnormal metabolism of nonesterified fatty acids (NEFAs) and their derivatives has been reported to be the main cause intracellular lipotoxic injury. Normally, NEFAs are stored in lipid droplets (LDs) form triglyceride (TG), which could reduce lipotoxicity cytosolic NEFAs. Previous studies have implicated that Perilipin 5 (Plin5), an LD‐binding protein, regulates storage hydrolysis TG LD. However, its roles underlying mechanisms liver remain unknown. Here we found Plin5 expression was...
Abstract Myocardial ischaemia-reperfusion (I/R) injury is a complex pathophysiological process. Current research has suggested that energy metabolism disorders, of which the abnormal consumption fatty acids closely related, compose main pathological basis for myocardial I/R injury. Lipid droplets (LD) are critical regulators lipid by LD-associated proteins. Among droplet proteins, perilipin family members regulate lipolysis and lipogenesis through different mechanisms. Plin5, an important...
Abstract Aims Diabetic cardiomyopathy, characterized by myocardial structural and functional changes, is a specific cardiomyopathy develops in patients with diabetes mellitus. The present study was to investigate the role of kinin B2 receptor-Akt-glycogen synthase kinase (GSK)-3β signalling pathway mediating protective effects tanshinone IIA (TSN) on diabetic cardiomyopathy. Methods results Streptozocin (STZ) induced rats (n = 60) were randomized receive TSN, TSN plus HOE140 (a receptor...
Interferon-regulatory factor 2 (IRF2)/inositol polyphosphate 4-phosphatase B (INPP4B) is essential for the differentiation of immune T cells. However, regulatory mechanism IRF2/INPP4B signaling pathway on apoptosis acute myeloid leukemia (AML) cells remains unclear. Thus, this study intended to investigate function and in development AML. CD4+ were isolated from peripheral blood identified using flow cytometry. Apoptosis AML cell line HL60 ration Th1/Th2 analyzed by The mRNA expression IRF2...
Sarcopenia is highly prevalent among candidates for transcatheter aortic valve implantation (TAVI). index, the ratio of serum creatinine to cystatin C, has been proposed be a novel biomarker in muscle assessment. Retrospective data were collected from patients diagnosed with stenosis who underwent TAVI. Body composition assessment was conducted, and nutrition intake recorded on total 127 patients. index demonstrated notably higher area under curve (AUC) compared bioelectrical impedance...
Cell death-inducing DFF45-like effector b (Cideb), an endoplasmic reticulum (ER)- and lipid droplet (LD)-associated protein, has been shown to play a critical role in maintaining hepatic homeostasis by promoting the lipidation maturation of VLDL particles. Here, we observed that Cideb is expressed jejunum ileum sections small intestine, its expression was induced high-fat diet. Intragastric gavage with lipids resulted retention intestine Cideb-deficient mice. In addition, mice deficiency...
Stem cell antigen (Sca) 1, a glycosyl phosphatidylinositol-anchored protein localized to lipid rafts, is upregulated in the heart during myocardial infarction and renovascular hypertension-induced cardiac hypertrophy. It has been suggested that Sca-1 plays an important role infarction. To investigate of hypertrophy, we performed aortic banding cardiac-specific transgenic mice, knockout their wild-type littermates. Cardiac hypertrophy was evaluated by echocardiographic, hemodynamic,...
Abstract Background Abdominal ectopic fat deposition and excess visceral depots in obesity may be related to cardiovascular disease (CVD) as both are involved the metabolic syndrome (MetS). The awareness of link between abdominal adiposity subclinical cardiac remodeling would help improve treatment outcome. Besides, liver fibrosis has also shown a potential relationship with dysfunction. Thus, we aimed investigate associations magnetic resonance (MR)-based hepatic shear stiffness left...
Abstract A number of randomized controlled trials and real‐world studies have demonstrated the effectiveness safety secukinumab in treatment moderate to severe psoriasis, whereas data on a large cohort Chinese patients long‐term practice are limited. This was single‐centre, uncontrolled, single‐arm, prospective, observational study that included 254 psoriatic treated with between September 2019 December 2022. Demographic clinical characteristics patients, response adverse events were...
Abstract Hepatic lipid accumulation is the most common pathological characteristic of alcoholic liver disease (ALD). In mammalian cells, excess neutral lipids are stored in droplets (LDs). As a member perilipin family proteins, Plin3 was recently found to regulate LD biogenesis. However, roles and mechanism ALD progression remain unclear. Herein, we that alcohol stimulated expression both mouse livers cultured AML12 hepatic which accompanied by hepatocytes. The elevations alcohol‐treated...
It was the aim of this study to investigate impact pulsed magnetic field (PMF) on ischemic myocardium, though it has been reported that PMF treatment is a safe and effective method facilitate bone cutaneous wound healing.In report, we describe in which 10 Hz 4 mT 15 6 used treat rats with myocardial infarction (MI).After 28 days treatment, treated exhibited decreased left ventricular end-diastolic pressure accelerated maximum dp/dt when compared untreated MI + groups. Additionally, capillary...
Heart failure is a disease with multifactorial causes. Recently it was established that reduction in vascular density promoted the progression from adaptive cardiac hypertrophy to heart failure, therefore, therapeutic angiogenesis may be promising method for treating failure. Cardiac microvascular endothelial cells (CMECs) play major role angiogenesis. In present study, we investigated direct and indirect effect of pulsed magnetic field (PMF) on proliferation migration CMECs. CMECs were...