A5075272735- Cancer-related molecular mechanisms research
- RNA Interference and Gene Delivery
- Neuroscience and Neuropharmacology Research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Cancer Mechanisms and Therapy
- Glycogen Storage Diseases and Myoclonus
- Molecular Biology Techniques and Applications
- Microtubule and mitosis dynamics
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pregnancy and Medication Impact
- Cardiac Ischemia and Reperfusion
- Pharmacological Effects and Assays
- Optical Wireless Communication Technologies
- Radar Systems and Signal Processing
- Optical Network Technologies
- Genetics and Neurodevelopmental Disorders
- Telomeres, Telomerase, and Senescence
- Anesthesia and Neurotoxicity Research
- Mechanisms of cancer metastasis
- Cell death mechanisms and regulation
- Renal Diseases and Glomerulopathies
- Speech and Audio Processing
- FOXO transcription factor regulation
- Cancer Cells and Metastasis
Air Force Medical University
2013-2024
First Affiliated Hospital of Xi'an Jiaotong University
2024
Xi'an Jiaotong University
2024
Xijing Hospital
2012-2023
Tang Du Hospital
2022
PLA Information Engineering University
2019
Mesenchymal stem cell-derived exosomes (MSC-Exo) have robust anti-inflammatory effects in the treatment of neurological diseases such as epilepsy, stroke, or traumatic brain injury. While astrocytes are thought to be mediators these effects, their precise role remains poorly understood. To address this issue, we investigated putative therapeutic and mechanism MSC-Exo on inflammation-induced alterations astrocytes. Methods: Lipopolysaccharide (LPS)-stimulated hippocampal primary culture were...
Purpose: Chemoresistance is the main cause of treatment failure in cancer and associated with distant metastases epithelial-to-mesenchymal transition (EMT). This study was aimed to explore mechanism EMT chemoresistant gastric cancer.Experimental Design: A key molecular pathway identified via gene profiling a bioinformatic analysis model. The roles FOXL2, HMGA2, ITGA2 were validated loss-of-function gain-of-function experiments vitro an orthotopic animal regulation FOXL2 by HMGA2 explored...
An increasing body of evidence indicates that miR-149 can both suppress and promote tumor growth depending on the type. However, role in progression gastric cancer (GC) remains unknown. Here we report is a suppressor human cancer. expression decreased GC cell lines clinical specimens comparison to normal epithelial tissues, respectively. The levels also correlate with differentiation degree cells tissues. Moreover, ectopic inhibits proliferation cycle by down-regulating ZBTB2, potent...
Myocardial infarction (MI) is a coronary artery-related disease and ranks as the leading cause of sudden death globally. Resveratrol (Res) bioactive component has presented antioxidant, anti-inflammatory anti-microbial properties. However, effect Res on ferroptosis during MI progression remains elusive. Here, we aimed to explore function in regulation myocardial injury MI. We observed that treatment attenuated MI-related myocardium fibrosis rats. The expression collagen 1 α-SMA was induced...
Abstract Background In medical training, statistics is considered a very difficult course to learn and teach. Current studies have found that students’ attitudes toward can influence their learning process. Measuring, evaluating monitoring the changes of are important. Few focused on postgraduates, especially postgraduates. Our purpose was understand current regarding held by postgraduates explore effects achievement. We also wanted influencing factors sources these monitor after systematic...
Cetuximab plus chemotherapy for advanced gastric cancer (GC) shows an active result in phase 2 trials. Unfortunately, Combination of cetuximab does not provide enough benefit to alone 3 Studies have demonstrated that berberine can suppress the activation EGFR tumors. In this study, we evaluated whether could enhance effects EGFR-TKIs GC cell lines and xenograft models. Our data suggest effectively activity erlotinib vitro vivo. Berberine was found inhibit growth induce apoptosis. These were...
Stathmin (Oncoprotein18), a signal transduction regulatory factor, plays an Important role In cell division and malignant tumor development. is ubiquitous intracellular phosphoprotein that overexpressed in variety of human malignancies, including osteosarcoma. To investigate the potential use stathmin as therapeutic target for osteosarcomas, we employed RNA interference [small interfering (siRNA)] to reduce expression osteosarcoma lines analyzed their phenotypic changes. Results showed...
Abstract A number of randomized controlled trials and real‐world studies have demonstrated the effectiveness safety secukinumab in treatment moderate to severe psoriasis, whereas data on a large cohort Chinese patients long‐term practice are limited. This was single‐centre, uncontrolled, single‐arm, prospective, observational study that included 254 psoriatic treated with between September 2019 December 2022. Demographic clinical characteristics patients, response adverse events were...
AbstractHuman telomerase is a ribonucleoprotein complex composed of two subunits, an RNA component (hTR) and human reverse transcriptase (hTERT). The activation telomerase, process regulated by the (hTERT), crucial step during cellular immortalization malignant transformation. hTERT overexpressed in most cells but undetectable normal somatic cells. To explore its possibility as therapeutic target for cervical carcinoma, we developed novel tumor-specific interference system targeting using...
Astrocytic glycogen plays an important role in brain energy metabolism. However, the contribution of metabolism to stress-induced depression remains unclear. Chronic social defeat stress was used induce depression-like behaviors mice, assessed with behavioral tests. Glycogen concentration medial prefrontal cortex (mPFC) and expression key enzymes were investigated using Western blots, immunofluorescent staining, electron microscopy, biochemical assays. Stereotaxic surgery viral-mediated gene...
Abstract Cerebral glycogen is principally localized in astrocytes rather than neurons. Glycogen metabolism has been implicated higher brain functions, including learning and memory, yet the distribution patterns of different types have not fully described. Here, we applied a method based on incorporation 2-NBDG, d -glucose fluorescent derivative that can trace glycogen, to investigate glycogen’s brain. We identified two astrocytes, namely, 2-NBDG I (glycogen-deficient) II (glycogen-rich)...
Alzheimer's disease (AD) is a chronic degenerative of the central nervous system and most common dementia type in elderly people. N-myc downstream-regulated gene 2 (NDRG2), cell stress response gene, primarily expressed astrocytes mammalian brains. The hippocampal protein levels NDRG2 AD patients were significantly higher than those healthy peers. However, whether increase involved development or an endogenous protective initiated by remains unknown. Here, we investigated roles memory...
This study addresses the joint time difference of arrival (TDOA) and frequency (FDOA) estimation problem in passive emitter localisation, involving range migration during observation time. A computational efficient algorithm based on scaled Fourier transformation is proposed. method can effectively remove RM accomplish parameter estimation. Cross‐terms suppression ability proposed also analysed its characteristic indicates applicability scenario multi‐targets. The whole step be fast...
Abstract General anesthesia severely affects the metabolites in brain. Glycogen, principally stored astrocytes and providing short-term delivery of substrates to neurons, has been implicated as an affected molecule. However, whether glycogen plays a pivotal role modulating anesthesia–arousal remains unclear. Here, we demonstrated that isoflurane-anesthetized mice exhibited dynamic changes levels various brain regions. Glycogen synthase (GS) phosphorylase (GP), key enzymes metabolism, showed...
Background . Excessive myocardial oxidative stress could lead to the congestive heart failure. NADPH oxidase is involved in pathological process of left ventricular (LV) remodeling and dysfunction. β 3‐Adrenergic receptor (AR) regulate cardiac dysfunction proved by recent researches. The molecular mechanism 3‐AR regulating stress, especially oxidase, remains be determined. Methods Cardiac hypertrophy was constructed transverse aortic constriction (TAC) model. ROS subunits expression were...
<title>Abstract</title> Background Despite the previous reports of patients with combined anti-glomerular basement membrane (anti-GBM) disease occurring sequentially or simultaneously other nephropathies, most them have been reported seperately. The complication these diseases is rare and mechanism not clear, their immuno-antibodies, microscopic picture, clinical presentation, treatment prognosis are different, therefore, we presented collection anti-GBM such as membranous nephropathy (MN),...
Acute respiratory failure (ARF) with a high incidence among moderate-to-severe traumatic brain injury (M-STBI) patients plays pivotal role in worsening neurological outcomes. Traumatic subarachnoid hemorrhage (tSAH) is highly prevalent M-STBI, which associated significant adverse In this retrospective cohort study, we aimed to explore the association between severity of tSAH and ARF M-STBI population. A total 771 subjects were reviewed. Clinical neuroimaging data retrospectively collected,...
Data of short-term visit for academic exchange at international level between 2008-2012 were analysed in terms discipline,personnel,visit type,target country,and communication.We explored the help these exchanges development various disciplines and hospital as a whole.Experience was drawn to better future growth hospital. Key words: Short term abroad; Academic exchange; Discipline construction; The Fourth Military Medical University; Tangdu Hospital
Due to the low complexity, peak cancellation algorithm (PC-CFR) can be applied reduce high peak-to-average ratio (PAPR) of orthogonal frequency division multiplexing (OFDM) signals. The core PC-CFR is that spectrum its correcting signal nearly identical OFDM signal, so waveform design becomes key component algorithm. In this paper, two parameters filter type and order, are studied. A number filters orders compared demonstrate fir1 with 122(order) performs great balance among PAPR reduction,...
Abstract Background: Liver transplantation (LT) is the optimal treatment option for hepatocellular carcinoma (HCC) meeting Extended Transplant Criteria (ELTC), but it only offered minority. The alternative strategy HCCs beyond Milan criteria (BMC) ELTC, which defined as modestly (MBMC) here, a matter of concern. aim this study was to evaluate survival benefits LR compared with transarterial chemoembolization (TACE) MBMC-HCCs. Methods: From January 2010 October 2021, from fifteen Chinese...