A5078481580- Neuroinflammation and Neurodegeneration Mechanisms
- Intensive Care Unit Cognitive Disorders
- Autophagy in Disease and Therapy
- Pain Mechanisms and Treatments
- Neurological Disease Mechanisms and Treatments
- Anesthesia and Neurotoxicity Research
- Acupuncture Treatment Research Studies
- Estrogen and related hormone effects
- Acute Ischemic Stroke Management
- Neuroscience and Neuropharmacology Research
- Menopause: Health Impacts and Treatments
- Immune Response and Inflammation
- Inflammasome and immune disorders
- Neonatal and fetal brain pathology
- S100 Proteins and Annexins
- Barrier Structure and Function Studies
- Stress Responses and Cortisol
- interferon and immune responses
- Peroxisome Proliferator-Activated Receptors
- Diabetic Foot Ulcer Assessment and Management
- Ferroptosis and cancer prognosis
- Advanced Glycation End Products research
- Cancer-related molecular mechanisms research
- Connexins and lens biology
- Simulation-Based Education in Healthcare
Xijing Hospital
2013-2024
Air Force Medical University
2013-2024
Tongji University
2023-2024
Fujian Provincial Hospital
2024
Fujian Medical University
2024
State Council of the People's Republic of China
2023
Our previous studies have shown that hyperbaric oxygen preconditioning (HBO-PC) induces tolerance to cerebral ischemia/reperfusion (I/R). This study aimed investigate whether SirT1, a class III histone deacetylase, is involved in neuroprotection elicited by HBO-PC animal and cell culture models of ischemia. Rats were subjected middle artery occlusion for 120 minutes after (once day 5 days). Primary cultured cortical neurons exposed 2 hours oxygen–glucose deprivation (OGD). We showed...
Sepsis-associated encephalopathy (SAE) is a common but serious complication in septic survivors and often causes long-term cognitive impairments. The role of RIPK3-participated necroptosis SAE remains obscured. STING key molecule regulating apoptosis. However, there uncertainty as to the mechanisms CLP-induced SAE. aim this study was investigate whether involved underlying mechanism SAE.The contextual fear conditioning test (CFCT) assesses impairment. A transmission electron microscope (TEM)...
Abstract Background With the widespread prevalence of neurodegenerative diseases (NDs) and high rates mortality disability, it is imminent to find accurate targets for intervention. There growing evidence that neuroimmunity pivotal in pathology NDs interventions targeting hold great promise. Exogenous or dislocated nucleic acids activate cytosolic DNA sensor cyclic GMP‐AMP synthase (cGAS), activating stimulator interferon genes (STING). The activated STING triggers innate immune responses...
Tat-CIRP perturbed the function of MD2 and provided robust neuroprotection in cells, rodents, gyrencephalic nonhuman primates.
Abstract Chaperone-mediated autophagy is one of three types and characterized by the selective degradation proteins. contributes to energy balance helps maintain cellular homeostasis, while providing nutrients support for cell survival. activity can be detected in almost all cells, including neurons. Owing extreme sensitivity neurons their environmental changes, maintaining neuronal homeostasis critical growth dysfunction closely related central nervous system diseases. It has been shown...
Background and Purpose— Endogenous neuroprotection can be induced by ischemic nonischemic preconditioning. However, not all subjects that undergo preconditioning exhibit similar favorable outcome. This study is to explore the molecules responsible for this phenomenon find new therapeutic targets stroke. Methods— Adult male Sprague–Dawley rats were subjected transient middle cerebral artery occlusion. High-throughput proteomic technique, isobaric tag relative absolute quantification, was used...
Abstract Background Perioperative neurocognitive disorder (PND) is a long-term postoperative complication in elderly surgical patients. The underlying mechanism of PND unclear, and no effective therapies are currently available. It believed that neuroinflammation plays an important role triggering PND. secreted glycoprotein myeloid differentiation factor 2 (MD2) functions as activator the Toll-like receptor 4 (TLR4) inflammatory pathway, α5GABA A receptors (α5GABA Rs) known to play key...
The plasma protein hemopexin (HPX) exhibits the highest binding affinity to free heme. In vitro experiments and gene-knock out technique have suggested that HPX may a neuroprotective effect. However, expression of in brain was not well elucidated its after cerebral ischemia-reperfusion injury also poorly studied. Furthermore, no vivo data were available on effect given centrally prognosis focal ischemia. present study, we systematically investigated normal rat by immunofluorescent staining....
With the aging of populations and high prevalence stroke, postoperative stroke has become a growing concern. This study aimed to establish prediction model assess risk factors for in elderly patients during period.ML (Machine learning) models were applied from MIMIC (Medical Information Mart Intensive Care)-III MIMIC-VI databases. The SMOTENC (synthetic minority oversampling technique nominal continuous data) balancing iterative SVD (Singular Value Decomposition) data imputation method used...
Electroacupuncture (EA) therapy has been widely reported to alleviate neuropathic pain with few side effects in both clinical practice and animal studies worldwide. However, little is known about the comparison of therapeutic efficacy among diverse EA schemes used for pain. The present study aimed at investigating discrepancy between single combined-acupoint reveal difference mechanisms behind them. was given Zusanli (ST36) Huantiao (GB30) combined group or ST36 alone group. Paw withdrawal...
We have previously reported that Cystatin C (CysC) is a pivotal mediator in the neuroprotection induced by hyperbaric oxygen (HBO) preconditioning; however, underlying mechanism and how CysC changes after stroke are not clear. In present study, we demonstrated expression was elevated as early 3 h reperfusion, this further enhanced HBO preconditioning. Concurrently, LC3-II Beclin-1, two positive-markers for autophagy induction, exhibited increases similar to CysC, while knockdown of blocked...
Chemokine CX3CL1 and its receptor CX3CR1 in the lumbar spinal cord play crucial roles pain processing. Electroacupuncture (EA) is recognized as an alternative therapy treatment due to efficacy safety. However, analgesic mechanism of EA remains unclear. The aim this study was investigate whether suppressed complete Freund's adjuvant (CFA)-induced via modulating CX3CL1-CX3CR1 pathway.Inflammatory induced by intraplantar injection CFA left hind paw Sprague-Dawley rats. with 2 Hz for 30 mins...
Sepsis-associated encephalopathy (SAE) is a complication of sepsis with high morbidity rates. Long-lasting mental health issues in patients SAE result substantial decrease quality life. However, its underlying mechanism unclear, and effective treatments are not available. In the current study, we explored role apoptosis necroptosis related to dysfunction sepsis. mouse model constructed by cecal ligation puncture (CLP), altered behavior was detected open field, elevated-plus maze forced...
Adiponectin (ADPN) plays an important role in cerebral ischemia-reperfusion injury. Although previous studies have confirmed that ADPN pretreatment has a protective effect on ischemic stroke, the therapeutic of stroke and underlying mechanism are still unclear. In order to clarify these questions, focal transient ischemia was induced by middle artery occlusion (MCAO) mice administered for three times at 6 h, 24 48 h after reperfusion. Meanwhile, virus-delivered HIF-1α siRNA used before...