A5045785596- Anesthesia and Neurotoxicity Research
- Intensive Care Unit Cognitive Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurosurgical Procedures and Complications
- Cerebrospinal fluid and hydrocephalus
- Pain Mechanisms and Treatments
- S100 Proteins and Annexins
- Acupuncture Treatment Research Studies
- Healthcare and Venom Research
- Traumatic Brain Injury Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Alzheimer's disease research and treatments
- Mental Health Research Topics
- Attention Deficit Hyperactivity Disorder
- Cardiac, Anesthesia and Surgical Outcomes
- Neuroscience and Neuropharmacology Research
- GDF15 and Related Biomarkers
- Treatment of Major Depression
- Opinion Dynamics and Social Influence
- Neuroinflammation and Neurodegeneration Mechanisms
- Lexicography and Language Studies
- Cancer, Stress, Anesthesia, and Immune Response
- Medicinal Plants and Neuroprotection
Air Force Medical University
2012-2025
Xijing Hospital
2019-2025
Shaanxi Provincial People's Hospital
2025
Shanxi Medical University
2025
Shanxi University
2019
Tang Du Hospital
2017
English and Foreign Languages University
2017
Abstract Aims This study was designed to investigate the role of NR2B and contribution DNA methylation expression in pathogenesis PND. Methods Eighteen‐month‐old C57BL/6J mice were subjected experimental laparotomy under 1.4% isoflurane anesthesia. Hippocampus‐dependent learning memory evaluated by using Barnes maze contextual fear conditioning tests. The protein mRNA levels western blotting qRT–PCR respectively, gene examined targeted bisulfite sequencing. Long‐term synaptic plasticity...
Background/Objectives: Voice analysis has shown promise in anxiety assessment, yet traditional approaches examining isolated acoustic features yield inconsistent results. This study aimed to explore the relationship between states and vocal parameters from a network perspective ecologically valid settings. Methods: A cross-sectional was conducted with 316 undergraduate students (191 males, 125 females; mean age 20.3 ± 0.85 years) who completed standardized picture description task while...
Abstract Background Perioperative neurocognitive disorder (PND) is a long-term postoperative complication in elderly surgical patients. The underlying mechanism of PND unclear, and no effective therapies are currently available. It believed that neuroinflammation plays an important role triggering PND. secreted glycoprotein myeloid differentiation factor 2 (MD2) functions as activator the Toll-like receptor 4 (TLR4) inflammatory pathway, α5GABA A receptors (α5GABA Rs) known to play key...
Two prevalent therapies for the treatment of spontaneous intracerebral hemorrhage (ICH) in basal ganglia are, minimally invasive puncture and drainage (MIPD), endoscopic surgery (ES). Because both surgical techniques are a nature, they have attracted greater attention recent years. However, evidence comparing curative effect MIPD ES has been uncertain. The indication or uncertain till now. In present study, 112 patients with ICH who received were reviewed retrospectively. Baseline parameters...
Under pathological conditions, acupoint sensitization is the phenomenon of acupoints transforming from stable state to dynamic state. Evidences suggest that hyperpolarization-activated current (Ih), conducted by hyperpolarization-activated/cyclic nucleotide-gated (HCN) channel, greatly contributes peripheral and central sensitization. However, role Ih in has not been explained. In present study, changes excitability, density HCN channel dorsal root ganglion (DRG) nociceptive neurons were...
The concept of “acupoint sensitization” refers to the functional status acupoint switches from silent active under pathological conditions. In clinic, sensitization provides important guidance for acupoints selection in different diseases. However, mechanism behind this phenomenon remains unclear. We generated a model knee osteoarthritis (KOA) by intra-articular injection monosodium iodoacetate (MIA) into left rats. paw withdrawal mechanical threshold (PWMT) and total number mast cells as...
The gene-regulatory landscape is highly dynamic in healthy and diseased brains. DNA methylation a well-known epigenetic modification that regulates gene expression, our previous study demonstrated S-adenosylmethionine (SAM), methylome modulator, was neuroprotectant against perioperative neurocognitive disorder (PND). However, the underlying mechanism remains to be elucidated. Here, we integrated an assay for transposase-accessible chromatin by sequencing (ATAC-seq) RNA (RNA-seq) identify key...
Background: Attention-deficit hyperactivity disorder (referred to as ADHD) was a typical neuropsychiatric characterized by inattention, impulsivity and hyperactivity, particularly in children. Recent studies demonstrated close relationship between the development of ADHD surgery under general anesthesia. However, few illustrated if symptom changed after surgery. Meanwhile, whether these individuals with natural neural impairment were sensitive postoperative neurocognitive remained unclear....
Abstract Objective: patients with moderate traumatic brain injury (TBI) are under the threat of intracranial hypertension(IHT), which is an important cause death and unfavorable outcome TBI patients. However, it unclear will develop IHT when to receive ICP-lowering treatment or even invasive ICP monitoring after admission. The purpose present study was validate a prediction model that estimates risk in lower GCS (9-11) by admission data. Methods : baseline data collected on 296 score 9-11...