A5000532423- Anesthesia and Neurotoxicity Research
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Pain Management
- RNA modifications and cancer
- S100 Proteins and Annexins
- Airway Management and Intubation Techniques
- Cancer-related molecular mechanisms research
- Neuroscience and Neuropharmacology Research
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiovascular Syncope and Autonomic Disorders
- RNA Research and Splicing
- Neonatal Health and Biochemistry
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Acute Ischemic Stroke Management
- Adenosine and Purinergic Signaling
- Frailty in Older Adults
- COVID-19 Clinical Research Studies
- Traditional Chinese Medicine Analysis
- Neurological Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Ferroptosis and cancer prognosis
- Asthma and respiratory diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Electrolyte and hormonal disorders
- Stress Responses and Cortisol
Tongji University
2021-2025
Shanghai East Hospital
2017-2018
m6A RNA methylation regulators can regulate the growth, progression, and invasion of glioma cells by regulating their target genes, which provides a reliable support for regulator–target axes as novel therapeutic targets clinical prognostic signature in glioma. This study aimed to explore role value targets. Expression profiles clinicopathological data were obtained from Chinese Glioma Genome Atlas (CGGA), The Cancer (TCGA), Gene Omnibus (GEO), Clinical Proteome Tumor Analysis Consortium...
Abstract Aims This study was designed to investigate the role of NR2B and contribution DNA methylation expression in pathogenesis PND. Methods Eighteen‐month‐old C57BL/6J mice were subjected experimental laparotomy under 1.4% isoflurane anesthesia. Hippocampus‐dependent learning memory evaluated by using Barnes maze contextual fear conditioning tests. The protein mRNA levels western blotting qRT–PCR respectively, gene examined targeted bisulfite sequencing. Long‐term synaptic plasticity...
The perioperative neurocognitive disorder (PND) is a severe complication that affects millions of surgical patients each year. Homocysteine (Hcy) known to increase the risk developing PND in both young and elderly mice. However, whether Hcy alone can induce cognitive deficits middle-aged mice (12-month-old), exercise attenuate Hcy-induced hippocampus-related after surgery through suppressing neuroinflammation, synaptic elimination, level remains unknown. present study aimed answer these...
Abstract Ischemic stroke (IS) is a leading cause of morbidity and mortality globally triggers series reactions to primary secondary brain injuries permanent neurological deficits. Microglia in the central nervous system play dual roles neuroprotection responding ischemic damage. Here, an IS model employed determine involvement microglia phagocytosis at excitatory synapses. Additionally, effects pharmacological depletion are investigated on improving neurobehavioral outcomes mitigating...
Perioperative neurocognitive disorder (PND) is a prevalent form of cognitive impairment in elderly patients following anesthesia and surgery. The underlying mechanisms PND are closely related to perineuronal nets (PNNs). PNNs, which complexes extracellular matrix primarily surrounding neurons the hippocampus, play critical role function. Connexin 43 (Cx43) contributes function by modulating components PNNs. This study was designed investigate specific regulatory Cx43 on PNNs its pivotal...
Idiopathic pulmonary fibrosis (IPF) is a progressive disease whose etiology remains unknown. The purpose of this study was to explore hub genes and pathways related IPF development prognosis. Multiple gene expression datasets were downloaded from the Gene Expression Omnibus database. Weighted correlation network analysis (WGCNA) performed differentially expressed (DEGs) identified investigate Hub modules correlated with IPF. Ontology (GO), Kyoto Encyclopedia Genes Genomes (KEGG) enrichment...
Preoperative anxiety is common and often comes with a higher probability of worse recovery. However, the neurological mechanism effect preoperative on general anesthesia subsequent awakening remains unknown. In this study, we report an anxious state results in delayed model mice from sevoflurane anesthesia. More profound inhibition DA neurons VTA contributes to awakening. Optogenetic stimulation can reverse delay. The indicate that may be involved delay caused by anxiety.
Aging is one of the greatest risk factors for postoperative cognitive dysfunction (POCD), also known as perioperative neurocognitive disorder (PND). Animal models PND are usually induced in mice over 18 months age, which imposes expensive economic and time costs PND-related studies. Sleep disorders, including sleep fragmentation, reported to aggravate memory impairment neurocognitive-related diseases such Alzheimer's disease (AD). Therefore, aim present study was explore whether a model...
To explore the potential mechanism of cancer patients appearing more vulnerable to SARS-CoV-2 infection and poor COVID-19 outcomes, we conducted an integrative bioinformatics analysis for SARS-CoV-2-required genes host variants related susceptibility severity. BLCA, HNSC, KIRC, KIRP, LGG, PCPG, PRAD, TGCT, THCA carrying rs10774671-A (OAS1) genotype may be likely have outcomes relative those who carry rs10774671-G, because individuals will lower expression OAS1, which serves as a protective...
The gene-regulatory landscape is highly dynamic in healthy and diseased brains. DNA methylation a well-known epigenetic modification that regulates gene expression, our previous study demonstrated S-adenosylmethionine (SAM), methylome modulator, was neuroprotectant against perioperative neurocognitive disorder (PND). However, the underlying mechanism remains to be elucidated. Here, we integrated an assay for transposase-accessible chromatin by sequencing (ATAC-seq) RNA (RNA-seq) identify key...
This study aimed to determine the upstream regulatory factors affecting ribosome biogenesis regulator 1 homolog (RRS1) expression and development prognosis of liver hepatocellular carcinoma (LIHC). The profiles RRS1 were evaluated in pan-cancer tissues tumor cell lines. associations with survival, immune infiltrations, checkpoints, drug sensitivity identified. We explored potential mechanisms expression. Hsa-miR-132-3p knockdown, CCK-8 assays, transwell, wound healing assays performed...
<title>Abstract</title> Background Perioperative neurocognitive disorder (PND) is a prevalent form of cognitive impairment in elderly patients following anesthesia and surgery. The underlying mechanisms PND are closely related to perineuronal nets (PNNs). PNNs, which complexes extracellular matrix primarily surrounding neurons the hippocampus, play critical role function. Connexin 43 (Cx43) contributes function by modulating components PNNs. This study was designed investigate specific...
Perioperative neurocognitive disorder (PND) is a severe postoperative complication in older patients. Epigenetic changes are hallmarks of senescence and closely associated with cognitive impairment. However, the effects anesthesia surgery on aging brain's epigenetic regulatory mechanisms its impact impairment remain unclear. Using laparotomy PND model, we report significant reduction DNA methyltransferase 3a (DNMT3a) hippocampal neurons aged mice, which causes global methylation decrease....
Hypoalbuminemia is common in critically ill patients, chronic hypoproteinemia tend to cause some negative impacts on the body's internal environment.Hypoalbuminemia poses many challenges perioperative anesthesia management.This article describes a case of difficult postoperative extubation 62-year-old woman with hypoalbuminemia.She was diagnosed intestinal tuberculosis, and edema for 3 years.During management process, we found physiological changes during period complex.So this article,...
Rationale: Favism is a genetic disease of Glucose 6 phosphatase dehydrogenase (G6PD) deficiency in human red blood cells.It mainly due to the mutation G6PD gene encoded on X chromosome, which leads decrease activity or deficiency.G6PD plays important roles metabolic process body.One them protect integrity erythrocyte membrane.When body lack its reduced, patient prone hemolysis after eating oxidant, such as fresh broad bean, under strong stress. Patient concerns and diagnoses:A 43 year old...
Objective: To find the faster and easier way than existing intubating technique for double-lumen tube. We prediction of required double lumen tube size by measure X-ray trachea diameter before surgery. Methods: Randomly selected 100 cases single lung ventilation in patients undergoing thoracic Measurement tracheal at level clavicle X-ray. Choose according to measurement If greater 16 mm, choose a 39 Fr tube, if between 15-16 used 37 with less 15 35 Record number intubation whether there is...
Acute asthma is very dangerous and frequently presents with sudden narrowing of the airways especially during perioperative period. Asthma poses many challenges to anesthesia management. This article describes a refractory acute extubation period in 35 year old man without any history asthma. There may be number factors that trigger asthma, so we reviewed some present literature analyze relationship between them older better guide clinical practices.
Background Pain in awake patients can be assessed on the basis of their subjective description. But pain assessment during surgery often depends several vital signs and practitioners' clinical experience, lacks specificity sensitivity. Objective To analyze summarize recent studies operative monitoring with surgical pleth index (SPI). Content This article presents procedures effectiveness SPI pain, summarizes application perioperative monitoring. used to assess balance between...