A5042976402- Cancer-related molecular mechanisms research
- Anesthesia and Neurotoxicity Research
- Intensive Care Unit Cognitive Disorders
- RNA modifications and cancer
- Neurological Disease Mechanisms and Treatments
- Thyroid Disorders and Treatments
- RNA Research and Splicing
- Luminescence Properties of Advanced Materials
- Radiation Detection and Scintillator Technologies
- Biochemical and Structural Characterization
- Cancer, Stress, Anesthesia, and Immune Response
- Enhanced Oil Recovery Techniques
- COVID-19 Clinical Research Studies
- Myasthenia Gravis and Thymoma
- Perovskite Materials and Applications
- Chemokine receptors and signaling
- Extracellular vesicles in disease
- Pickering emulsions and particle stabilization
- Electrohydrodynamics and Fluid Dynamics
- Surface Modification and Superhydrophobicity
- Microbial Metabolic Engineering and Bioproduction
- Electrospun Nanofibers in Biomedical Applications
- COVID-19 and healthcare impacts
- Cytokine Signaling Pathways and Interactions
- DNA and Nucleic Acid Chemistry
Tongji University
2019-2024
Dalian Medical University
2024
Second Affiliated Hospital of Dalian Medical University
2023-2024
University of St Andrews
2022-2024
Soochow University
2022-2023
Shanghai Institute of Pollution Control and Ecological Security
2021-2022
State Key Laboratory of Pollution Control and Resource Reuse
2021-2022
Yangzhou University
2019
Northwest A&F University
2015-2018
m6A RNA methylation regulators can regulate the growth, progression, and invasion of glioma cells by regulating their target genes, which provides a reliable support for regulator–target axes as novel therapeutic targets clinical prognostic signature in glioma. This study aimed to explore role value targets. Expression profiles clinicopathological data were obtained from Chinese Glioma Genome Atlas (CGGA), The Cancer (TCGA), Gene Omnibus (GEO), Clinical Proteome Tumor Analysis Consortium...
Idiopathic pulmonary fibrosis (IPF) is a progressive disease whose etiology remains unknown. The purpose of this study was to explore hub genes and pathways related IPF development prognosis. Multiple gene expression datasets were downloaded from the Gene Expression Omnibus database. Weighted correlation network analysis (WGCNA) performed differentially expressed (DEGs) identified investigate Hub modules correlated with IPF. Ontology (GO), Kyoto Encyclopedia Genes Genomes (KEGG) enrichment...
The conformational equilibria of selectively halogenated cyclohexanes are explored both experimentally (VT-NMR) for 1,1,4,-trifluorocyclohexane 7 and by computational analysis (M06-2X/aug-cc-pVTZ level), with the latter approach extending to a wider range more highly fluorinated cyclohexanes. Perhaps unexpectedly, 7ax is preferred over 7eq conformation ΔG = 1.06 kcal mol–1, contradicting accepted norm substituents on axial preference stronger again in 1,1,3,3,4,5,5,-heptafluorocyclohexane 9...
Abstract: Nano-sized Y2Mo4O15:Eu3+ was synthesized by the pechini method. The crystalline phase confirmed structural refinements. photoluminescence (PL) excitation and emission spectra, decay lifetimes were investigated. phosphors can be efficiently excited near-ultraviolet light exhibit a red luminescence around 616 nm from forced electric dipole transition 5D0→7F2 of Eu3+ ions. thermal stability investigated temperature-dependent intensities. ions to distribute in one kind crystallographic...
To explore the potential mechanism of cancer patients appearing more vulnerable to SARS-CoV-2 infection and poor COVID-19 outcomes, we conducted an integrative bioinformatics analysis for SARS-CoV-2-required genes host variants related susceptibility severity. BLCA, HNSC, KIRC, KIRP, LGG, PCPG, PRAD, TGCT, THCA carrying rs10774671-A (OAS1) genotype may be likely have outcomes relative those who carry rs10774671-G, because individuals will lower expression OAS1, which serves as a protective...
The p53 tumor suppressor exerts antitumor functions through its ability to regulate the transcription of downstream targets. Long noncoding RNAs (lncRNAs) act as oncogenes or suppressors implicated in tumorigenesis and progression. Here, we identify lncRNA LINC00324 (long intergenic RNA 00324) a direct transcriptional target. Knockdown expression promotes growth by reducing activity, whereas ectopic demonstrates reverse effect. Notably, is present endogenous complex cells directly binds...
Abstract Purpose In this study, iodine stimulated Nthyori3-1 cell was used as the research object to explore relationship between high thyroid cells and ferroptosis, further clarify its pathogenesis. This study will help provide new clues for treatment of related diseases. Methods Intervene human normal with iodine. The levels apoptosis proliferation were detected by CCK-8 MDA. protein Nrf2、HO-1、p-ERK1 GPX4 determined western blotting. Flow cytometry performed detect ROS production. Results...
Perioperative neurocognitive disorder (PND) is a severe postoperative complication in older patients. Epigenetic changes are hallmarks of senescence and closely associated with cognitive impairment. However, the effects anesthesia surgery on aging brain's epigenetic regulatory mechanisms its impact impairment remain unclear. Using laparotomy PND model, we report significant reduction DNA methyltransferase 3a (DNMT3a) hippocampal neurons aged mice, which causes global methylation decrease....
Abstract Background Hashimoto’s thyroiditis (HT) is the most common autoimmune thyroid disease (AITD), which distinguished by high peroxidase antibody (TPOAb) or thyroglobulin (TgAb). The differentiation of CD4 + T cell subsets in patients with HT imbalanced, Treg cells decreased and Th17 abnormally activated. Fatty acid oxidation supports induces inflammation, but specific mechanism still unknown. This study aimed to explore role fatty its pathway pathogenesis immune mechanism. Methods In...
Postoperative complications, such as perioperative neurocognitive disorders (PND), have become a major issue affecting surgical outcomes. However, the mechanism of PND remains unclear, and stable animal models middle-aged are lacking. S-adenosylmethionine (SAM), cystathionine beta-synthase (CBS) allosteric activator, can reduce level plasma homocysteine prevent occurrence PND. time resource-intensive process constructing in elderly animals limited progress research innovative therapy...
C-2 fluorinated and methylated stereoisomers of the fragrance citronellol 1 its oxalate esters were prepared from (R)-pulegone 11 explored as agonists human olfactory receptor OR1A1 assayed also against site-specific mutants. There clear isomer preferences difluorination in 18 led to most active compound suggesting an important hydrogen bond donor role for 1. methylation corresponding ester analogues less active.
Abstract Background TgAb and TPOAb are effective sensitive diagnose index for HT which is a common AID.TgAb present varying degrees correlatuion with different metabolites in gender. However, the morbidity female higher than male HT. The research exploring correction between metabolic positive-TgAb or positive-TPOAb patients still absent. Methods 14 healthy, TPOAb(+), 4 TgAb(+) serum sample were included. Metabolites detected using LC-MS. Sstatistical analysis performed by SPSS. PLS-DA...
Abstract Objective: This study aimed to explore the controllable risk factors, metabolic characteristics and potential biomarkers of T2DM-MCI provide proof for diagnosis, prevention treatment cognitive impairment in T2DM patients. Methods: 103 patients who were hospitalized Endocrinology Department Second Hospital Dalian Medical University included. MoCA was used evaluate function all subjects. 50 included group (MoCA score <26 points), 53 subjects T2DM-NCI ≥ 26 points). Serum samples...
Abstract Background This study aimed to analyze the clinical features of Graves' Diseases (GD) with and without thymic hyperplasia (TH). Methods Between 2018 2020, we reviewed 257 patients GD. Based on thyroid evaluations radiological, clinical, serological findings, were divided into TH + group (GD disorders in their thymus glands) or TH- normal glands). Then compared differences between groups. Results Of GD patients, 151 (58.75%) classified group. There was no significant difference...
A large variety of cellular signals are triggered and transmitted by protein-protein interactions (PPIs). Long noncoding RNAs regulate PPIs enhancing or destabilizing these interactions. Here, we use the proximity ligation assay technique to determine between p53 SET regulated long intergenic RNA 324 (LINC00324). We detail procedures for establishing LINC00324 knockdown overexpression U2OS HepG2 cells followed in situ PLA protocol. This approach has many potential applications study factors...