A5100388626- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Mesenchymal stem cell research
- Monoclonal and Polyclonal Antibodies Research
- Immunodeficiency and Autoimmune Disorders
- Nanoplatforms for cancer theranostics
- Advanced Breast Cancer Therapies
- MicroRNA in disease regulation
- Glioma Diagnosis and Treatment
- Electrospun Nanofibers in Biomedical Applications
- Bone and Joint Diseases
- Advanced Sensor and Energy Harvesting Materials
- Chronic Myeloid Leukemia Treatments
- Osteoarthritis Treatment and Mechanisms
- Immune Response and Inflammation
- Nanoparticle-Based Drug Delivery
- Immune cells in cancer
- Gaze Tracking and Assistive Technology
- Birth, Development, and Health
- Mitochondrial Function and Pathology
- Glycosylation and Glycoproteins Research
- Salivary Gland Disorders and Functions
- Tissue Engineering and Regenerative Medicine
- Real-time simulation and control systems
- Autophagy in Disease and Therapy
The Fourth People's Hospital of Zibo City
2025
Nanchang University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2025
Peking Union Medical College Hospital
2024-2025
Soochow University
2015-2024
China Agricultural University
2013-2024
Dalian Medical University
2011-2024
Second Affiliated Hospital of Dalian Medical University
2011-2024
Shandong Agricultural University
2024
Ministry of Agriculture and Rural Affairs
2024
Minimal change disease (MCD) is a podocytopathy more commonly seen in children, but it also accounts for 10%-25% of adult nephrotic syndrome. High-dose oral glucocorticoids were recommended initial treatment MCD. However, long-term use systemic corticosteroids associated with significant adverse events, such as steroid-induced diabetes and infections. The aim this study was to investigate the clinical efficacy safety half-dose combined rituximab (RTX) We recruited 74 patients MCD confirmed...
Chronic lymphocytic leukemia (CLL) represents the outgrowth of a CD5+ B cell. Its etiology is unknown. The structure membrane Ig on CLL cells unrelated patients can be remarkably similar. Therefore, antigen binding and stimulation could contribute to clonal selection expansion as well disease promotion. Initial studies suggest that mAbs bind autoantigens. Since apoptosis make autoantigens accessible for recognition by antibodies, also create neo-epitopes chemical modifications occurring...
A novel nanostructured ferroelectric photovoltaic material, consisting of the lead zirconate titanate (PZT) film and Ag2O semiconductor nanoparticles comparatively narrow bandgap, has demonstrated a remarkable enhancement in effects highest light-electricity conversion efficiency among those PZT-based photodiodes previously reported. This work sheds light on design enhanced performance new optoelectronic solar energy devices.
Quantitatively tracking engraftment of intracerebrally or intravenously transplanted stem cells and evaluating their concomitant therapeutic efficacy for stroke has been a challenge in the field cell therapy. In this study, first, an MRI/SPECT/fluorescent tri‐modal probe ( 125 I‐fSiO4@SPIOs) is synthesized quantitatively mesenchymal (MSCs) into rats, then MSCs delivered by both routes possible mechanism therapy are evaluated. It demonstrated that (125) I‐fSiO4@SPIOs have high efficiency...
Choroidal neovascularization (CNV) is the leading cause of vision loss in many blinding diseases, but current antiangiogenic therapies with invasively intravitreal injection suffer from poor patient compliance and a rate devastating ocular complications. Here, we develop an alternative agent based on hybrid cell-membrane-cloaked nanoparticles for noninvasively targeted treatment CNV. The retinal endotheliocyte membrane coating provides as-fabricated nanoagents homotypic targeting capability...
Mesenchymal stem cells (MSC) from healthy human and normal mice can inhibit B cell proliferation, differentiation, Ab secretion in vitro. However, it remains unknown whether MSC lupus-like patients with systemic lupus erythematosus (SLE) exhibit the same immunoregulatory activity as for inhibition and, if not, what underlying molecular mechanism would be. In this study, we showed that bone marrow-derived MSCs SLE had an impairment suppressing proliferation which was caused by reduction of...
Our previous study proved that nanofat could enhance fat graft survival by promoting neovascularization. Fat extract (FE), a cell-free component derived from nanofat, also possesses proangiogenic activity.The aim of this was to investigate whether FE improve and work synergistically promote survival. The underlying mechanism investigated.In the first animal study, human macrofat lipoaspirate co-transplanted into nude mice with or nanofat. grafts were evaluated at 2, 4 12 weeks...
Mesenchymal stem cells (MSCs) possess multipotent and immunomodulatory properties are suggested to be involved in the pathogenesis of immune-related diseases. This study explored function bone marrow MSCs from rheumatoid arthritis (RA) patients, focusing on effects. RA showed decreased proliferative activity aberrant migration capacity. No significant differences were observed cytokine profiles between control MSCs. The effects proliferation peripheral blood mononuclear (PBMCs) distribution...
Abstract Rapid advances in robotics have placed urgent demands on more intelligent human‐machine interaction technologies. Specifically, the way of establishing dual‐way intuitive communication with a consistent sensory system can greatly enhance efficiency and reliability. Here, bi‐directional interface (HMI) is designed by applying starch‐based hydrogel sensors. The whole consists multi‐modal wearable exoskeleton haptic feedback module robotic hand. strain‐sensing glove rotation‐sensing...
Abstract The development of efficient therapeutic strategies to promote ferroptotic cell death offers significant potential for hepatocellular carcinoma (HCC) treatment. Herein, this study presents an HCC‐targeted nanoplatform that integrates bimetallic FeMoO 4 nanoparticles with CO‐releasing molecules, and further camouflaged SP94 peptide‐modified macrophage membrane enhanced ferroptosis‐driven multi‐modal therapy HCC. Leveraging the multi‐enzyme activities multivalent metallic elements,...
Abstract Immune checkpoint inhibitors (ICIs) have shifted the treatment paradigm of non‐small cell lung cancer (NSCLC) over last decade. Despite notable therapeutic advancements in responders, response rate remains limited owing to immunosuppressive tumor microenvironment (TME). Therefore, improve efficacy ICIs, it is essential explore alternative targets or signals that mediate immunosuppression. Immunoglobulin‐like transcript (ILT) 5 a negative regulator immune activation myeloid cells....
TAFRO syndrome, entailing thrombocytopenia, anasarca, fever, reticulin fibrosis, and organomegaly, was previously considered a subtype of idiopathic multicentric Castleman disease (iMCD-TAFRO), with the diagnosis requiring pathology supporting disease. However, lymph node biopsies may be difficult for patients (TAFRO without pathological evidence: TAFRO-w/op-iMCD), sometimes these do not confirm iMCD (TAFRO-w/o-iMCD). We aimed to compare clinical features prognosis subgroups. retrospectively...
Objective To investigate the clinical characteristics,treatment responses,and prognosis of patients with idiopathic multicentric Castleman disease(iMCD)complicated by autoimmune hemolytic anemia(AIHA). Methods The diagnosed iMCD in Peking Union Medical College Hospital from January 2010 to December 2023 and having complete baseline blood routine data were retrospectively enrolled study.The further assigned into AIHA non-AIHA groups based on laboratory examinations,and characteristics...
Ocular neovascularization can result in devastating diseases that lead to marked vision impairment and eventual visual loss. In clinical implementation, neovascular eye are first diagnosed by fluorescein angiography then treated multiple intravitreal injections, which nevertheless involves vision-threatening complications, as well lack of real-time monitoring disease progression timely assessment therapeutic outcomes. To address this critical issue, we herein present a kind theranostic...
This study aimed to determine whether umbilical cord-derived mesenchymal stem cells (UCMSC) regulate Cadherin-11 (CDH11) expression by fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA). FLS were isolated from the synovium of RA and osteoarthritis (OA) patients. patients cocultured with UCMSC a transwell system. CDH11 mRNA levels tested, soluble factors expressed UCMSC, such as indoleamine 2,3-dioxygenase (IDO), hepatocyte growth factor (HGF), interleukin- (IL-) 10, determined....
Glioblastoma is the most malignant tumor and has high mortality rate. The methylated prompter of MGMT results in chemotherapy sensitivity for these patients. However, there are still other factors that affected prognosis glioblastoma patients with similar methylation status. We developed a signature three genes screened from whole genome mRNA expression profile Chinese Glioma Genome Atlas (CGGA) RNAseq data Cancer (TCGA). Patients low risk group had longer survival than those (median overall...
Autologous fat grafting is commonly used for soft-tissue augmentation and reconstruction. However, this technique limited by a high rate of graft absorption. Thus, approaches to improve survival that promote neovascularization are great interest. Nanofat has several beneficial features may render it more suitable clinical applications than other stem-cell based approaches.We aimed determine whether nanofat could enhance new vessel formation the long-term retention grafts.Nanofat was...
Sentinel lymph node (SLN) detection is of great significance for the prevention and treatment cancer metastasis. Herein, we introduce silicon nanoparticles (SiNPs)-based exosome (SiNPs@EXO) probes distinguishing normal metastatic SLNs. Typically, SiNPs are suitable stable long-term tracking exosomes, while cell-driven exosomes with a tumor-homing effect allow targeting Remarkably, as-fabricated SiNPs@EXO has ability to label SLNs, i.e., fluorescence signal in SLNs reaches peak within 0.5 h...