A5012061967- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Functional Brain Connectivity Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Advanced Neuroimaging Techniques and Applications
- Botulinum Toxin and Related Neurological Disorders
- Intracerebral and Subarachnoid Hemorrhage Research
- Heme Oxygenase-1 and Carbon Monoxide
- Spatial Neglect and Hemispheric Dysfunction
- Traumatic Brain Injury Research
- Sulfur Compounds in Biology
- Genetic Neurodegenerative Diseases
- Autophagy in Disease and Therapy
- Circular RNAs in diseases
- Microbial infections and disease research
- Alzheimer's disease research and treatments
- Cerebral Palsy and Movement Disorders
- Neuroscience of respiration and sleep
- Genomics, phytochemicals, and oxidative stress
- Mind wandering and attention
- Cancer-related molecular mechanisms research
- Nerve injury and regeneration
- Transcranial Magnetic Stimulation Studies
- Neurogenetic and Muscular Disorders Research
- Monoclonal and Polyclonal Antibodies Research
Nanjing Brain Hospital
2019-2025
Nanjing Medical University
2019-2025
Shandong Academy of Agricultural Sciences
2020-2024
Poultry Research Institute
2024
China Medical University
2016-2023
Liaoning University
2022
Ningbo No.6 Hospital
2021
XinHua Hospital
2018
Shandong Agricultural University
2016-2017
Anhui Medical University
2012-2016
Ferroptosis and iron-related redox imbalance aggravate traumatic brain injury (TBI) outcomes. NRF2 is the predominant transcription factor regulating oxidative stress neuroinflammation in TBI, but its role iron-induced post-TBI damage unclear. We investigated ferroptotic neuronal injured cortex observed neurological deficits post-TBI. These were ameliorated by iron chelator deferoxamine (DFO) wild-type mice. In Nrf2-knockout (Nrf2-/-) mice, more sever ferroptosis detected. Dimethyl fumarate...
Abstract Background MicroRNAs (miRNAs) play important regulatory roles in development and stress response plants. Wild soybean ( Glycine soja ) has undergone long-term natural selection may have evolved special mechanisms to survive conditions as a result. However, little information about miRNAs especially responsive aluminum (Al) is available wild soybean. Results Two small RNA libraries two degradome were constructed from the roots of Al-treated Al-free G. seedlings. For miRNA...
Hydrogen sulfide (H2S), a novel gaseous mediator, has been recognized as an important neuromodulator and neuroprotective agent in the central nervous system. The present study was undertaken to effects of exogenous H2S on traumatic brain injury (TBI) underlying mechanisms. TBI were examined by using measurement edema, behavior assessment, propidium iodide (PI) staining, Western blotting, respectively. Compared groups, pretreatment had reduced improved motor performance ameliorated Morris...
Heat stress (HS) causes significant economic losses in the poultry industry every year. However, mechanisms for adverse effects of HS on avian follicular development are largely unknown. The aim this study was to test whether induces apoptosis cells and impairs egg production by activating FasL/Fas tumor necrosis factor (TNF)-α systems. To end, Hy-Line Brown laying hens, at 32 wk age, were either exposed 35°C 37°C or maintained 24°C 26°C (control) 5 D. At end period, follicle numbers,...
Abstract Background In Parkinson's disease (PD), inflammation may lead to the degeneration of dopaminergic (DAergic) neurons. Previous studies showed that inflammatory mediators mainly contributed this phenomenon. On other hand, invasive neuromodulation methods such as deep brain stimulation (DBS) have better therapeutic effects for PD. One possibility is DBS improves PD by influencing inflammation. Therefore, we further explored mechanisms underlying and in pathogenesis Methods We measured...
This article aims to study tripartite motif-containing protein 3 (TRIM3) effects on Parkinson's disease (PD). TRIM3 expression in venous blood of PD patients was detected by qRT-PCR. mouse model and SH-SY5Y cell were constructed. cells treated LY294002 (a PI3K inhibitor). The apoptosis midbrain detected. Glutathione (GSH) superoxide dismutase (SOD) level mice analyzed. Intracellular reactive oxygen species (ROS) MMP effect viability, PI3K/AKT signal pathway As a result, decreased....
Excessive iron released by hemoglobin and necrotic tissues is the predominant factor that aggravates outcome of traumatic brain injury (TBI). Regulating levels its metabolism a feasible way to alleviate damage due TBI. However, spatial-temporal deposition in neurons glial cells after TBI remains unclear. In our study, male C57BL/6 mice (8-12 weeks old, weighing 20-26 g) were conducted using controlled cortical impact (CCI) models, combined with treatment chelator deferoxamine (DFO), followed...
Spinocerebellar ataxia (SCA) is a genetically heterogeneous neurodegenerative disorder lacking effective treatments currently. While noninvasive cerebellum neuromodulation showed positive results, invasive techniques like deep brain stimulation (DBS) have not been fully assessed for SCA patients. This study evaluated the treatment outcomes of DBS targeting cerebellar dentate nucleus (DN) in six patients (SCA1, SCA3, SCA12) over six-month follow-up. Bilateral DN-DBS leads were precisely...
Deep Brain Stimulation (DBS) is an established treatment option for movement disorders such as Parkinson's disease and dystonia, so more patients (over 160,000 till 2019) worldwide have undergone DBS a variety of neurological non-neurological conditions, with numbers increasing each year. This case series primarily discusses very rare complication following surgery -- brain abscess. We administered vancomycin metronidazole to who developed abscesses after undergoing based on previous...
Background and Objectives: Robotic exoskeletons show potential in PD gait rehabilitation. But the optimal assistive force its equivalence to clinical gold standard assessments are unclear. This study aims explore of lower limb exoskeleton evaluating patients' disorders find best for use. Methods: In this prospective controlled trial, 60 patients (Hoehn Yahr stages 2-4) age-matched controls underwent quantitative analysis using a portable (Relink-ANK-1BM) at four levels (0 N, 40 80 120 N)....
Objective STN-DBS is an effective treatment for Parkinson’s disease (PD), improving motor symptoms, but its impact on non-motor such as anxiety and depression, remain unclear. This study investigates the relationship between electrode contact locations, their corresponding volume of tissue activated (VTA), postoperative changes in emotional symptoms. It aims to identify optimal group-level stimulation sites depression PD patients develop a structural connectome explore how cortical regions...
Loss of endothelial barrier function plays an important role in the development ventilator-induced lung injury (VILI). This study aimed to investigate effects miR135a on VILI a model mechanical stretch (MS)-induced human umbilical vein cell (HUVEC) injury.HUVECs were randomly assigned 7 groups: blank, negative control (NC), NC+MS, over-expression (mi-miR135a), mi-miR135a + MS, silencing (si-miR135a) and si-miR135a MS groups. was induced by subjecting cells cyclic at 20% for 4 h. After 24 h,...
The aim of the present study was to screen for biomarkers Parkinson's disease (PD) using proteomics and bioinformatics approaches. PD patients were divided into three groups: Those without surgery (PD1 group); those who had undergone deep brain stimulation (DBS) electrode (PD2 DBS with 1 month (PD3 group). non-Parkinson control group (CK group) also involved. Quantitative proteomic analysis human sera performed through use tandem mass tag markers liquid chromatography-mass spectrometry...
Background Parkinson’s disease (PD) symptoms deteriorate with progression. Although deep brain stimulation (DBS) can effectively improve the motor signs of PD patients, it is not yet known whether DBS surgery, which an invasive treatment modality, may change progression PD. Objective The aim this work was to compare effect that drug on Methods A total 77 patients Hoehn and Yahr scale (HY) stage 2.5 or 3 were included, divided into 34 in therapy alone group (Drug-G) 43 (DBS-G). All subjected...
ABSTRACT Background Patients with disorders of consciousness (DOC) undergoing spinal cord stimulation (SCS) for arousal treatment require an assessment their conscious state before and after the procedure. This is typically evaluated using behavioral scales (CRS‐R), but this method can be influenced by subjectivity physician. Event‐related potentials (ERP) EEG power spectrum are associated recovery consciousness. study aims to explore electrophysiological evidence in DOC patients investigate...
Objective . The aim of this work was to investigate whether there are differences in the executive control network (ECN) between patients with Parkinson’s disease (PD) before and after deep brain stimulation (DBS) surgery explore how affects ECN connectivity PD. Methods Resting-state magnetic resonance imaging (MRI) data were obtained from 23 preoperatively (pre-PD) postoperatively (post-PD) 14 normal controls (CN). right dorsolateral prefrontal cortex (DLPFC) used as seed region interest...