Xi Shen

ORCID: 0000-0001-7568-7335
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About
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Research Areas
  • Retinal Diseases and Treatments
  • Central Venous Catheters and Hemodialysis
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Retinal Imaging and Analysis
  • Cerebral Venous Sinus Thrombosis
  • Vascular Procedures and Complications
  • Glaucoma and retinal disorders
  • Mitochondrial Function and Pathology
  • Cassava research and cyanide
  • Plant Molecular Biology Research
  • Intracerebral and Subarachnoid Hemorrhage Research
  • Autophagy in Disease and Therapy
  • Bacterial biofilms and quorum sensing
  • Vibrio bacteria research studies
  • Peptidase Inhibition and Analysis
  • Vascular anomalies and interventions
  • Heat shock proteins research
  • Diabetes, Cardiovascular Risks, and Lipoproteins
  • Enhanced Recovery After Surgery
  • Cardiac and Coronary Surgery Techniques
  • Vascular Malformations and Hemangiomas
  • Nutrition, Genetics, and Disease
  • IL-33, ST2, and ILC Pathways
  • Sulfur Compounds in Biology
  • RNA regulation and disease

Soochow University
2015-2025

First Affiliated Hospital of Soochow University
2025

Wuhan Hankou Hospital
2025

Eli Lilly (United States)
2023-2025

Shanghai Jiao Tong University
2020-2024

Ruijin Hospital
2006-2024

Hunan Agricultural University
2024

Ministry of Agriculture and Rural Affairs
2024

Sichuan University
2020-2022

West China Hospital of Sichuan University
2020-2021

Epidemiological and genetic data have implicated lipoprotein(a) as a potentially modifiable risk factor for atherosclerotic disease aortic stenosis, but there are no approved pharmacological treatments.

10.1001/jama.2023.21835 article EN JAMA 2023-11-12

To explore the association of diabetic retinopathy (DR) with TyG index and TyG-related parameters among United States population.This cross-sectional study is conducted in adults diabetes mellitus based on National Health Nutrition Examination Survey (NHANES) from 2005 to 2018. Multivariate logistic regression, restricted cubic spline, trend test, receiver operating characteristic curve subgroup analysis are adopted uncover DR parameter levels diabetics.An aggregate 888 eligible participants...

10.3390/jpm13030495 article EN Journal of Personalized Medicine 2023-03-09

BACKGROUND Thirst management in convalescent patients recovering from a digestive surgery performed under general anesthesia requires attention. A simple, practical, and safe method can effectively relieve thirst symptoms such patients. AIM To evaluate the enhanced recovery after (ERAS)-based evidence-based care (EBC) plus ice stimulation therapy for of following anesthesia. METHODS total 191 convalescing between March 2020 February 2023 experiencing were selected. In total, 89 102 control...

10.4240/wjgs.v17.i3.100185 article EN World Journal of Gastrointestinal Surgery 2025-02-24

This study explores the multi-level regulatory roles of lactate metabolism gene network in oral cancer development using machine learning models. Machine analysis shows that lactate-related expression profiles can effectively distinguish treatment groups from controls (AUC=0.933), with SLC16A1 and KIF2C being key features. Genes like PFKP, LDHA, LDHB, LDHC, VCAN are highlighted for their biological relevance. involved glycolytic metabolic regulation, is significantly upregulated patients,...

10.1101/2025.03.19.25324051 preprint EN medRxiv (Cold Spring Harbor Laboratory) 2025-03-20

BackgroundElevated lipoprotein(a) concentrations are associated with atherosclerotic cardiovascular disease. The safety and efficacy of lepodisiran, an extended-duration, small interfering RNA targeting hepatic synthesis lipoprotein(a), unknown.MethodsWe randomly assigned participants in a 1:2:2:2:2 ratio to receive lepodisiran at dose 16 mg, 96 or 400 mg baseline again day 180, placebo all administered by subcutaneous injection. Data from the two groups that received were pooled for primary...

10.1056/nejmoa2415818 article EN New England Journal of Medicine 2025-03-30

Summary Soil microbiome comprises numerous microbial species that continuously interact with each other. Among the modes of diverse interactions, cell–cell killing may play a key role in shaping composition. Bacteria deploy various secretion systems to fend off other microorganisms and Type IV Secretion System (T4SS) pathogenic bacteria was shown function as contact‐dependent, inter‐bacterial system only recently. The present study investigated played by T4SS behaviour soilborne biocontrol...

10.1111/1462-2920.15662 article EN Environmental Microbiology 2021-07-06

Soil bacteria possess multiple weapons to fend off microbial competitors. Currently, we poorly understand the factors guiding bacterial decisions about weapon systems deployment. In this study, investigated how such are made by soil bacterium Lysobacter enzymogenes, used in antifungal plant protection. We found that production is guided environmental cues. rich media, which likely mimic environments crowded with other microbes, L. enzymogenes produces a contact-dependent weapon, type six...

10.1371/journal.ppat.1008967 article EN cc-by PLoS Pathogens 2020-10-09

To investigate changes in retinal circulation and the choroid patients with acute myeloid leukemia (AML) remission stages, to analyze correlation between laboratory parameters, assess risk factors associated leukemic retinopathy.Forty-eight (93 eyes) AML were enrolled divided into two groups according fundus examination findings: retinopathy no groups. Patients underwent eye measurements before treatment after remission. Macular vessel density (VD), perfusion (PD), foveal avascular zone...

10.3389/fmed.2023.1117204 article EN cc-by Frontiers in Medicine 2023-03-13

POEMS syndrome is a rare paraneoplastic disorder associated with an underlying plasma cell dyscrasia presenting polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes. This study reviewed the clinical characteristics of 14 patients in Zhongshan hospital. The ratio male to female was 9 : 5, average age 47.1 years. manifestations were various, including motorial symptoms (weakness), sensory (numbness), lymphadenopathy, edema, abdominal distention, hyperpigmentation....

10.5402/2012/584287 article EN ISRN Gastroenterology 2012-04-01

Whilst there are effective techniques for the recanalization of central venous occlusions, chronic total occlusions remains particularly challenging. This study aims to evaluate safety and efficacy using a transseptal needle in right brachiocephalic vein (RBV) long-term hemodialysis patients.In this single-center, retrospective study, maintenance patients with occlusion RBV were enrolled between February 2017 March 2019 from West China Hospital Sichuan University. Refractory lesions defined...

10.21037/atm-20-5369 article EN Annals of Translational Medicine 2020-09-01

Cucumber (<italic>Cucumis sativus</italic> L.) is an important vegetable crop worldwide. Over the last two decades, there have been many breakthroughs in understanding of various developmental processes cucumber, such as shoot branching, sex differentiation, and leaf fruit size shape. Roots play role plant growth development nutrient absorption, affect yield, participate interaction between plants abiotic stress signals. However, discovery essential genes cucumber roots very limited....

10.48130/vr-2023-0019 article EN cc-by Vegetable Research 2023-01-01

The hairy root induction system was used to efficiently investigate gene expression and function in plant root. Cucumber is a significant vegetable crop worldwide, with shallow roots, few lateral weak systems, resulting low nutrient absorption utilization efficiency. Identifying essential genes related development an effective way improve the growth of cucumbers. However, genetic mechanisms underlying cucumber have not been explored. Here, we report novel, rapid, transformation system....

10.1080/15592324.2024.2345983 article EN cc-by Plant Signaling & Behavior 2024-04-30

Central vein occlusion (CVO) is a serious problem in hemodialysis patients. There an unsatisfactory result for refractory CVO by sharp recanalization alone. This study evaluated the efficacy and safety of blunt impingement followed treatment patients.This retrospectively examined patients with who failed to recanalize using standard guidewire catheter techniques our department. In first instance, all CVOs were recanalized techniques, including 6-Fr long sheath (Cook Incorporated,...

10.21037/atm-22-3131 article EN Annals of Translational Medicine 2022-07-01
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