A5026539403- Retinal Diseases and Treatments
- Ophthalmology and Visual Impairment Studies
- Corneal surgery and disorders
- Retinopathy of Prematurity Studies
- Retinal Imaging and Analysis
- Glaucoma and retinal disorders
- Ocular Surface and Contact Lens
- Advanced Glycation End Products research
- Retinal Development and Disorders
- Genetics, Aging, and Longevity in Model Organisms
- Corneal Surgery and Treatments
- Allergic Rhinitis and Sensitization
- Neonatal and fetal brain pathology
- Carbon and Quantum Dots Applications
- Nanocomposite Films for Food Packaging
- Nasolacrimal Duct Obstruction Treatments
- Ocular Infections and Treatments
- Electrochemical sensors and biosensors
- NF-κB Signaling Pathways
- Acne and Rosacea Treatments and Effects
- Lipid metabolism and disorders
- Neurogenetic and Muscular Disorders Research
- Lysosomal Storage Disorders Research
- Postharvest Quality and Shelf Life Management
- Advancements in Transdermal Drug Delivery
Northwestern Polytechnical University
2025
Children's Hospital of Fudan University
2008-2024
Shanghai First People's Hospital
2022-2024
Shanghai Jiao Tong University
2022-2024
Henan University of Technology
2023
Shanghai Eye Disease Prevention & Treatment Center
2023
National Taiwan University Hospital
2023
Anhui Agricultural University
2022-2023
MaineHealth
2023
University of Maine
2023
Abstract Irreversible bacterial resistance and impenetrable biofilms have rendered conventional antibiotic therapy ineffective. Nevertheless, increasing evidence has confirmed that carbon nanodots (CDs) exhibit potent antibacterial activity. However, the complex chemical composition of CDs, and, hence, their mechanism, is difficult to understand. The design new CDs against an urgent requirement.In this study, kanamycin‐sulfate‐derived (KCDs) are found significant potential with assistance...
Abstract Ageing generates senescent pathologies, some of which cause death. Interventions that delay or prevent lethal pathologies will extend lifespan. Here we identify life-limiting in Caenorhabditis elegans with a necropsy analysis worms have died old age. Our results imply the presence multiple causes Specifically, two classes corpse: early deaths swollen pharynx (which call ‘P deaths’), and later an atrophied (termed ‘p deaths’). The effects interventions on lifespan can be broken down...
Fresh-cut fruit requires an edible and water-resistant coating to remain fresh. This article investigated the effects of transglutaminase (TGase) sunflower oil on characteristics, mechanical properties, microstructure a whey protein-based film. The emulsion coating’s preservation effect fresh-cut apples was confirmed. According findings, (added at 1.5% w/w) could interact with β-lactoglobulin, α-lactoglobulin dimer, β-lactoglobulin dimer form droplets that are evenly dispersed throughout...
In model organisms, over 2,000 genes have been shown to modulate aging, the collection of which we call 'gerontome'. Although some individual aging-related subject intense scrutiny, their analysis as a whole has limited. particular, genetic interaction aging and age-related pathologies remain debate. this work, perform systematic gerontome across species, including human genes. First, by classifying pro- or anti-longevity, define distinct pathways that in different ways. Our subsequent...
To study the characteristics and associated factors of retinal microvascular abnormalities in children with type 1 diabetes mellitus (T1DM) without visual impairment diabetic retinopathy (DR).Case-control hospital-based including or DM. Optical coherence tomography angiography (OCTA; CIRRUS HD-OCT model 5000) was used to scan 6 × mm square area posterior retina optic disc. The indexes analyzed mainly included vascular length density (VD), perfusion (PD), foveal avascular zone area,...
Thermal-actuation and piezoresistive-detection effects have been employed to pump the effective quality factor of MEMS resonators, targeting simple self-oscillation better sensing performance in air. However, ratio pumped inherent mechanical factor, crucial for characterizing amplification, is hard obtain. The main difficulty stems from hidden Lorentz peaks caused by feedthrough effect once current applied. In this paper, we demonstrated presence high-order harmonic components output...
Paraneoplastic cerebellar degeneration (PCD) is a heterogeneous group of neurologic syndromes associated with primary tumors. It postulated that the immune system targets tumor antigen also expressed endogenously in nervous system. The majority these patients are diagnosed breast cancer or gynecological cancer, while it exceedingly rare lung squamous cell carcinoma (LUSC) patients. Here we reported case anti-Yo antibody-positive PCD patient LUSC and got successfully treated via immunotherapy...
Posttraumatic stress disorder (PTSD) is characterized by acute and chronic changes in the response, manifested as conditioned fear memory. Previously formed memories that are susceptible to disruption immediately after retrieval undergo a protein synthesis-dependent process become persistent, termed reconsolidation, regulated many distinct molecular mechanisms control gene expression. Increasing evidence supports participation of transcription factor NF-κB different phases Here, we...
To investigate the effect of OK lens treatment zone decentration on myopia control. We retrospectively selected 30 wearers who met following conditions in our hospital from more than 1300 cases: wearing both eyes and only one eye was off-center while other centric for 12 months. During period follow-up, UCVA each better 0.1 logMAR there were no obvious tropia, Kappa angle, complications such as glare diplopia. Among cases, 15 are males females, with an average age 9.3 ± 1.51Y. There...
Abstract Purpose To determine the pattern of axial variation in subjects with initial shortened length during entire period orthokeratology and to discuss possibility AL after one month becoming a predictor myopia control. Method This study retrospectively included 106 children aged 8 14 wearing OK lenses. Fifty-four eyes (AL) at first-month visit were enrolled shortening (ALS) group, fifty-two without no (NALS) group. Axial refractive error baseline within (20 months), including fitting,...
Bacterial infections pose a serious threat to human health, and the development of new antibiotics has not kept pace with bacterial resistance. Therefore, there is an urgent need design antibiotic-like nano-formulations that break through resistance mechanisms. In this work, we successfully synthesized safe effective antibacterial nano-formulation Se@Ag@EGCG by self-assembly epigallocatechin gallate (EGCG)-coated silver nanoparticles (Ag) on surface selenium nanowires (Se). Thein...
To determine the differences in myopia control efficiency and corneal reshaping between three different brands of orthokeratology (OK) lenses (Lucid, Euclid, Alpha).
Purpose: To compare the prevalence of dry eye disease between children with and without diabetes, analyze factors associated in diabetes.Materials methods: 38 diabetes were selected as cases, 40 constituted control group. The both groups was statistically analyzed. Related analyzed diabetes.Results: case group significantly higher than that (P < .01), attributable proportion among exposed (0.827) population fraction (0.700). Univariate analysis showed duration, best-corrected visual acuity,...
Various epidemiological studies have focused on the adverse health outcomes of meteorological factors. However, there has been little research impact humidex allergic conjunctivitis, especially in child and adolescent populations. We aimed to explore humidex, a comprehensive index relative humidity temperature, conjunctivitis admissions.
To investigate the changes in optic disc morphology and peripapillary atrophy (PPA) diabetic children adults without retinopathy (DR) or visual impairment (VI).This cross-sectional study included two groups of subjects. One group 91 with type 1 diabetes mellitus (T1DM) 86 healthy children, other 444 T2DM 442 controls. The parameters including major minor axis lengths, ovality (ODO), tilt, area β-PPA were analysed all Optic rotation Bergmeister papilla only children. Patients controls...
Abstract Purpose To study the characteristics of choroid thickness ( CT ) optic disc and macula in children with type 1 diabetes mellitus (T1 DM without visual impairment diabetic retinopathy DR analyse associated factors. Methods A square area 6 × mm around centre was scanned. The indices analysed mainly included at macular (1 mm), temporal, superior, nasal or inferior aspect inner ring (1–3 mm) outer (3–6 macula. Independent risk factors were using multifactor linear regression. Results...
Purpose: To analyze the characteristics of ocular surface microbial composition in children and adolescents with diabetes mellitus dry eye (DE) by tear analysis. Methods: We selected 65 aged 8 to 16 years DE non–DE 33 healthy same age group from Shanghai Children Adolescent Diabetes Eye Study. Tears were collected for high-throughput sequencing V3 V4 region 16S rRNA. The microbiota diabetic (DM-DE; n = 31), (DM-NDE; 34), (NDM; 33) groups studied. QIIME2 software was used each group. Results:...
Purpose To study changes in the thickness of retinal nerve fiber layer (RNFL) and ganglion cell (GCL) children with type 1 diabetes mellitus (T1DM) without visual impairment or diabetic retinopathy (DR) after 2 years follow-up analyze associated factors.Methods Thirty-seven T1DM were enrolled this study. All underwent a complete ophthalmologic evaluation that included swept-source optical coherence tomography at baseline follow-up. Changes RNFL GCL compared among follow-up.Results The...
•Neurodegeneration precede microcirculatory deterioration in DR. Early signs can be seen DM patients without visible DR symptoms, such as glial cell apoptosis and thinner retinal nerve fiber layer.•Peripapillary microvascular abnormalities the peripapillary region may affect normal metabolism of neurons eventually aggravate process DR.•Prompting ongoing research to monitor microcirculation microvasculature among T1DM children for early detection prevention.•In longitudinal observation,...
Abstract Background To investigate whether iris blood flow and thickness at the smooth muscle region affect pupil diameter rest after drug-induced mydriasis in patients with type 1 diabetes mellitus (T1DM) 2 (T2DM). Methods T1DM healthy children were recruited from SCADE cohort. T2DM adults undergoing cataract surgery Shanghai General Hospital. Iris vessel density, (PD) measured both resting states. density was by optical coherence tomography angiography (OCTA), PD a pupilometer, regions...
This study compares the ocular biometry with or without myopia in children type 1 diabetes mellitus (T1DM) and healthy China to analyse difference between T1DM children.A case-control was conducted at Children's Hospital of Fudan University. The were divided into four subgroups depending on non-myopia, non-DM. participants evaluated for anterior chamber depth (ACD), lens thickness (LT), axial length (AL), average keratometry (K) power (P). Furthermore, cycloplegic refraction performed...