A5059214692- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Advanced Glycation End Products research
- Ocular Surface and Contact Lens
- Ocular Infections and Treatments
- Retinopathy of Prematurity Studies
- Oral microbiology and periodontitis research
- Retinal Imaging and Analysis
- Ophthalmology and Visual Impairment Studies
- Liver Disease Diagnosis and Treatment
- Diabetes and associated disorders
- Connexins and lens biology
- Reproductive Biology and Fertility
- Folate and B Vitamins Research
- Gestational Diabetes Research and Management
- Eicosanoids and Hypertension Pharmacology
- Corneal surgery and disorders
- Genetic and Kidney Cyst Diseases
- Birth, Development, and Health
- Sperm and Testicular Function
- Stress Responses and Cortisol
- Connective Tissue Growth Factor Research
Shanghai Jiao Tong University
2020-2024
Shanghai First People's Hospital
2020-2024
Shanghai Eye Disease Prevention & Treatment Center
2020-2023
National Clinical Research
2023
To study the differences in blood cellular communication network factor 1 (CCN1) levels between patients with diabetes mellitus (DM) and healthy individuals to explore relationship CCN1 diabetic retinopathy (DR).Plasma were detected using ELISA 50 controls, 74 without (DM group), 69 (DR group). Correlations age, body mass index, mean arterial pressure, hemoglobin A1c, other factors analyzed. The expression DR was explored logistic regression after adjusting for confounding factors. Blood...
Purpose: To analyze the characteristics of ocular surface microbial composition in children and adolescents with diabetes mellitus dry eye (DE) by tear analysis. Methods: We selected 65 aged 8 to 16 years DE non–DE 33 healthy same age group from Shanghai Children Adolescent Diabetes Eye Study. Tears were collected for high-throughput sequencing V3 V4 region 16S rRNA. The microbiota diabetic (DM-DE; n = 31), (DM-NDE; 34), (NDM; 33) groups studied. QIIME2 software was used each group. Results:...
Background/aims We aim to explore the effect of sympathetic nervous system (SNS) on choroid thickness (ChT) and axial length (AL). Methods Students grade 2 3 from a primary school were included followed for 1 year. Visual acuity, refraction, AL ChT measured. Morning urine samples collected determining SNS activity by analysing concentrations epinephrine, norepinephrine dopamine using liquid chromatography-tandem mass spectrometry. The most important factor (factor 1) was calculated analysis...
Purpose To study changes in the thickness of retinal nerve fiber layer (RNFL) and ganglion cell (GCL) children with type 1 diabetes mellitus (T1DM) without visual impairment or diabetic retinopathy (DR) after 2 years follow-up analyze associated factors.Methods Thirty-seven T1DM were enrolled this study. All underwent a complete ophthalmologic evaluation that included swept-source optical coherence tomography at baseline follow-up. Changes RNFL GCL compared among follow-up.Results The...
Abstract Background To investigate whether iris blood flow and thickness at the smooth muscle region affect pupil diameter rest after drug-induced mydriasis in patients with type 1 diabetes mellitus (T1DM) 2 (T2DM). Methods T1DM healthy children were recruited from SCADE cohort. T2DM adults undergoing cataract surgery Shanghai General Hospital. Iris vessel density, (PD) measured both resting states. density was by optical coherence tomography angiography (OCTA), PD a pupilometer, regions...
Abstract Semen analysis is used for diagnosing male infertility and evaluating fertility more than a century. However, the semen simply represents population characteristics of sperm. It not comprehensive assessment reproductive potential. In this study, 20 samples from human sperm bank with distinctive artificial insemination donor (AID) clinical outcomes were collected analyzed using two-dimensional differential in-gel electrophoresis (2D-DIGE); 45 differentially expressed protein spots...
Abstract Background Great variation has been observed in the composition of normal microbiota ocular surface, and therefore, addition to differences detection techniques, method collecting surface specimens a significant impact on test results.The goal this study is ascertain whether eye microbial communities detected by two different sampling methods are consistent hence explore feasibility using tear paper instead conjunctival swabs collect samples for investigation. Materials From July...
Purpose: To investigate the incidence and risk factors of dry eye in children with diabetes mellitus (DM) over a period 3 years. Methods: Children adolescents DM (age: 3-14 years) from Shanghai Adolescent Diabetes Eye (SCADE) study cohort who did not have January 2018 were followed-up for years re-examined 2021, rate calculated. Results: Forty came follow-up 2021. Nine them diagnosed eye, resulting 3-year 22.5% an annual mean 7.5% eye. Univariate regression analysis confirmed that decreased...
Abstract Purpose To investigate the relationship between serum 12-Hydroxyeicosatetraenoic acid (12-HETE) and diabetic retinopathy (DR) in children with type 1 diabetes mellitus (T1DM) adults 2 (T2DM). Methods Children from Shanghai Adolescent Diabetes Eye (SCADE) study Cohort Study of Diabetic Disease (SCODE) were examined 2021. Serum 12-HETE levels detected compared. Multivariate logistic regression was used to analyze rate DR patients. Results The child included 4 patients new-onset 24...
This study aimed to investigate the characteristics of retinal nerve fiber layer (RNFL) thickness, ganglion cell (GCL) and choroidal thickness in children with moderate-to-high hyperopia (MHH). was a cross-sectional that enrolled 53 MHH emmetropic children. Subjects spherical equivalent refraction (SER) +4.0 D or higher were included group, subjects SER between -1.0 +1.0 group. Ophthalmic examinations, including uncorrected visual acuity, cycloplegic refraction, slit-lamp examination, axial...
Microbiome changes on the ocular surface may cause dry eyes. A metagenome assay was used to compare microbiome composition and function of between diabetic children adolescents with eye, without normal children.Twenty aged 8 16 diabetes were selected from Shanghai Children Adolescent Diabetes Eye Study. Ten healthy belonging same age group outpatient clinic during period. The participants classified into eye (DM-DE group, n = 10), non-dry (DM-NDE 10) (NDM 10). conjunctival sac swab collected...
To identify the differential methylation sites (DMS) and their according genes associated with diabetic retinopathy (DR) development in type 1 diabetes (T1DM) children.
Diabetes mellitus may compromise the vasculature of iris, thereby leading to severe vision-threatening complications. This study aimed investigate differences in iris blood flow indices between pediatric type 1 diabetes (T1DM) patients and adult 2 (T2DM) patients.This was a cross-sectional study. Pediatric T1DM healthy children were members Shanghai Children Adolescent Eye (SCADE) cohort who visited Hospital February 2022. The T2DM adults General from October 2021 January Iris OCTA acquired...
Abstract Purpose: To investigate differences in iris blood flow indices between pediatric type 1 diabetes mellitus (T1DM) patients and adult 2 (T2DM) patients. Methods: This was a cross-sectional study. Pediatric T1DM healthy children were members of the Shanghai Children Adolescent Diabetes Eye (SCADE) cohort who visited Hospital February 2022. The T2DM adults General from October 2021 to January Iris OCTA acquired through Cirrus HD-OCT 5000 angiography system (Carl Zeiss Meditec, Inc.). A...
Abstract Background: To identify the differential methylation sites (DMS) and their according genes associated with diabetic retinopathy (DR) development in type 1 diabetes (T1DM) children. Methods/Results: This study consists of two surveys. 40 T1DM children no DR participated first survey. Their DNA status was assessed by Illumina 850K array BeadChip assay. Comparison patterns made between participants macular retinal thinning (cases) others (controls). The second survey included 27...
Abstract Background: To identify the differential methylation sites (DMS) and their according genes associated with diabetic retinopathy (DR) development in type 1 diabetes (T1DM) children. Methods/Results: This study consists of two surveys. 40 T1DM children no DR participated first survey. Their DNA status was assessed by Illumina 850K array BeadChip assay. Comparison patterns made between participants macular retinal thinning (cases) others (controls). The second survey included 27...
Background: Diabetic retinopathy (DR) is the most common and severe ocular microvascular complication of diabetes. The relationship between dietary intake, gut microbial abundance, bile acid (BA), DR remains incompletely understood from a population perspective.Methods: We detected serum composition non-DR patients type 1 diabetes (T1D) children cohort 2 (T2D) adult by liquid chromatography-mass spectrometry. A questionnaire investigated their daily nutritional intake. Their fecal samples...
Abstract Background: Great variation has been observed in the composition of normal microbiota ocular surface, and therefore, addition to differences detection techniques, method collecting surface specimens a significant impact on test results.The goal this study is ascertain whether eye microbial communities detected by two different sampling methods are consistent hence explore feasibility using tear paper instead conjunctival swabs collect samples for investigation. Materials methods:...