A5064710618- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Glaucoma and retinal disorders
- Vascular Malformations Diagnosis and Treatment
- Moyamoya disease diagnosis and treatment
- Retinal and Optic Conditions
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurological Disease Mechanisms and Treatments
- Acute Ischemic Stroke Management
- Ocular Surface and Contact Lens
- Retinal and Macular Surgery
- NF-κB Signaling Pathways
- Cardiovascular Syncope and Autonomic Disorders
- Corneal Surgery and Treatments
- Corneal surgery and disorders
- Venous Thromboembolism Diagnosis and Management
- Body Composition Measurement Techniques
- Intracerebral and Subarachnoid Hemorrhage Research
- Advanced Glycation End Products research
- Ophthalmology and Visual Impairment Studies
- Retinopathy of Prematurity Studies
- Bone health and osteoporosis research
- Neurological Disorders and Treatments
Shanghai Eye Disease Prevention & Treatment Center
2018-2024
Shanghai Jiao Tong University
2012-2024
Shanghai First People's Hospital
2012-2024
Fujian Provincial Cancer Hospital
2024
Chinese University of Hong Kong
2024
University of Hong Kong
2024
Singapore General Hospital
2020-2024
SingHealth
2024
Harbin Medical University
2024
Second Affiliated Hospital of Harbin Medical University
2024
This study was performed to evaluate the prevalence and clinical characteristics of dry eye disease (DED) in community-based type 2 diabetic patients identify associated factors related with DED.A total 1360 Beixinjing community were randomly selected. All participants given a questionnaire that assessed basic information subjective symptoms.DED diagnosed using revised Japanese DED diagnostic criteria. subjects underwent routine ophthalmic examination, corneal sensitivity test, tear film...
Background Community-based telemedicine screening for diabetic retinopathy (DR) has been highly recommended worldwide. However, evidence from low- and middle-income countries (LMICs) on the choice between artificial intelligence (AI)–based manual grading–based is inadequate policy making. Objective The aim of this study was to test whether AI model more worthwhile than grading in community-based DR context labor costs urban China. Methods We conducted cost-effectiveness cost-utility analyses...
To assess the diagnostic efficacy of optical coherence tomography (OCT) and OCT angiography (OCTA) in Parkinson's disease (PD).OCT was used to obtain macular parameters peripapillary retinal nerve fiber layer (RNFL) thickness. The superficial vessel foveal avascular zone (FAZ) were quantified with OCTA. area under receiver operating characteristic curve (AUC) indicated parameters.Thirty-five eyes from 35 PD patients age-matched healthy subjects who served as controls evaluated. mean RNFL...
Community nurses in Singapore support vulnerable older persons with chronic health condition(s). In the situation of scaled-down community and social services during COVID-19 outbreak, nursing team adopted measures for pandemic preparedness. This report is to share General Hospital experience, preparation transforming efforts pandemic. Team segregation, active screening triage before visits other precautionary were executed minimise risk exposure COVID-19. There was a shift from face-to-face...
Abstract Background This study investigates the variations in microbiome abundance and diversity on ocular surfaces of diabetic patients suffering from dry eye within a community setting. The goal is to offer theoretical insights for community-level prevention treatment cohorts. Methods Dry screening was performed Shanghai Cohort Study Diabetic Eye Disease (SCODE) July 15, 2021, August Xingjing community; this included both population with diabetes normal population. group (DM-DE, n = 40)...
With the diabetes mellitus (DM) prevalence increasing annually, human grading of retinal images to evaluate DR has posed a substantial burden worldwide. SmartEye is recently developed fundus image processing and analysis system with lesion quantification function for screening. It sensitive area can automatically identify position size. We reported diabetic retinopathy (DR) results versus ophthalmologists in analyzing captured non-mydriatic cameras community healthcare centers, as well...
Background: Gallbladder cancer (GBC) is an aggressive and highly lethal biliary tract malignancy, with extremely poor prognosis. In the present study, we analyzed potential involvement of MYBL2, a member Myb transcription factor family, in carcinogenesis human GBC. Methods: MYBL2 expression levels were measured GBC cholecystitis tissue specimens using quantitative real-time PCR (qRT-PCR) immunohistochemical (IHC) assays. The effects on cell proliferation DNA synthesis evaluated Cell Counting...
Gallbladder cancer (GBC) is the most common malignancy in biliary tract. Without effective treatment, its prognosis notoriously poor. Tea polyphenols (TPs) have many pharmacological and health benefits, including antioxidant, anti-inflammatory, anti-tumor, anti-thrombotic, antibacterial, vasodilatory properties. However, anti-cancer effect of TPs human gallbladder has not yet been determined. Cell viability colony formation assay were used to investigate cell growth. cycle apoptosis...
To understand the referral completion and explore associated barriers to after telescreening for diabetic retinopathy (DR) among people with vision-threatening DR (VTDR).All participants VTDR in communities completed self-reported questionnaires assess their perspectives on barriers. Sociodemographic characteristics perceived related incomplete referrals were identified by conducting univariate analysis multiple logistic regression model. The final model was then built predict referral.Of...
<b><i>Purpose:</i></b> To analyze the relationships between choroidal thickness (CT) and diabetes mellitus (DM), diabetic retinopathy (DR), DR severity in community residents diagnosed with type 2 DM, to explore whether CT can improve discriminatory ability of other risk factors predict incidence DR. <b><i>Methods:</i></b> A total 1,250 DM 1,027 healthy controls Xinjing Shanghai participated a cross-sectional survey eye diseases 2016. was...
To investigate the changes in optic disc morphology and peripapillary atrophy (PPA) diabetic children adults without retinopathy (DR) or visual impairment (VI).This cross-sectional study included two groups of subjects. One group 91 with type 1 diabetes mellitus (T1DM) 86 healthy children, other 444 T2DM 442 controls. The parameters including major minor axis lengths, ovality (ODO), tilt, area β-PPA were analysed all Optic rotation Bergmeister papilla only children. Patients controls...
Abstract Purpose To study the characteristics of choroid thickness ( CT ) optic disc and macula in children with type 1 diabetes mellitus (T1 DM without visual impairment diabetic retinopathy DR analyse associated factors. Methods A square area 6 × mm around centre was scanned. The indices analysed mainly included at macular (1 mm), temporal, superior, nasal or inferior aspect inner ring (1–3 mm) outer (3–6 macula. Independent risk factors were using multifactor linear regression. Results...
It was reported that lack of knowledge, less confidence medical services, commute difficulties, and poor economic conditions would be the main barriers for cataract surgery practice. The influencing factors could have changed in cities with high developing speed. Shanghai is one biggest China world. purpose study to explore practice Shanghai. This a population-based, cross-sectional study. A total 2342 patients older than 50 years old cataract-induced visual impairment or who had undergone...
Cataract surgery can cause macular thickness change. We used optical coherence tomography (OCT) to assess the of different regions after femtosecond laser-assisted cataract age-related cataracts (ARC) and myopia cases with (myopia group). Fifty eyes 50 patients in ARC group fifty were included. All study underwent was measured at pre-operation 1 week, month surgery. There are significant differences foveal (P = 0.02), volume 0.02) average retinal between two groups before operation. In...
Abstract This study analyzed the optical coherence tomography angiography (OCTA) macular parameters in primary angle-closure glaucoma (PACG) patients after acute angle closure (APAC) episodes. Thirty-three with 33 APAC eyes and suspect (PACS) age-matched normal subjects (controls) were enrolled. Macular vessel density (VD) central, inner, outer full regions foveal avascular zone (FAZ) (area, perimeter circularity index) compared between APAC, PACS, control eyes. For resolved eyes, VD each...
AIM: To predict the visual outcome in patients undergoing macular hole surgery by two novel three-dimensional morphological parameters on optical coherence tomography (OCT): area ratio factor (ARF) and volume (VRF). METHODS: A clinical case series was conducted, including 54 eyes of with an idiopathic (IMH). Each patient had OCT examination before after surgery. Morphological hole, such as minimum diameter, base height were measured. Then, index (MHI), tractional (THI), form (HFF)...
Abstract Background The goal of this study was to investigate the anti-angiogenic activity a novel peptide H-RN, derived from hepatocyte growth factor kringle 1 domain (HGF K1), in mouse model corneal neovascularization. effect H-RN on vascular endothelial (VEGF)-stimulated cell proliferation, migration and tube formation assessed vitro using Human Umbilical Vein Endothelial Cells (HUVECs) vivo cornea micropocket assay. Apoptosis cycle arrest were by flow cytometry. A scrambled used as...
Cell-mediated immunity is often suppressed in patients with hematological malignancies. Recently, we found that low T cell receptor (TCR)-CD3 signaling was related to abnormal expression of the negative regulator nuclear factor kappa B (NF-κB) A20 acute myeloid leukemia. To investigate characteristics immunodeficiency lymphomas, analyzed features and its upstream regulating mucosa-associated lymphoid tissue lymphoma translocation gene 1 (MALT1) genes downstream NF-κB different subtypes,...
Knowledge of the oncogenic signaling pathways T-cell acute lymphoblastic leukemia (T-ALL) remains limited. Constitutive aberrant activation nuclear factor kappa B (NF-κB) pathway has been detected in various lymphoid malignancies and plays a key role development these carcinomas. The zinc finger-containing protein, A20, is central regulator multiple NF-κB-activating cascades. A20 frequently inactivated by deletions and/or mutations several B-and lymphoma subtypes. However, few polymorphisms...