A5102869463- Osteoarthritis Treatment and Mechanisms
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Spine and Intervertebral Disc Pathology
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Peptidase Inhibition and Analysis
- Cancer-related gene regulation
- Hip and Femur Fractures
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer Immunotherapy and Biomarkers
- Blockchain Technology Applications and Security
- Spinal Fractures and Fixation Techniques
- Atmospheric aerosols and clouds
- Musculoskeletal pain and rehabilitation
- Advanced Image Processing Techniques
- Metallurgical Processes and Thermodynamics
- Adipose Tissue and Metabolism
- Mesenchymal stem cell research
- Acoustic Wave Resonator Technologies
- Cancer Mechanisms and Therapy
- Cryptography and Data Security
- Mechanical and Optical Resonators
- Bat Biology and Ecology Studies
Soochow University
2018-2025
First Affiliated Hospital of Soochow University
2018-2025
Shanghai Jiao Tong University
2016-2025
Yanshan University
2024-2025
XinHua Hospital
2015-2025
Harbin Institute of Technology
2021-2025
Chinese PLA General Hospital
2023-2025
Jiangsu Cancer Hospital
2022-2024
Nanjing Medical University
2020-2024
East China Normal University
2010-2024
•Epithelial subtype 1, 2 and 3 were mainly found in the adenocarcinoma 4 was present adenosquamous carcinoma.•Tumors with ErbB pathway mutations harbored a larger population of 1 epithelial cells, Tregs, M2 macrophages.•Increased MDK these tumors interacted its receptor LRP1 to promote immunosuppressive macrophage differentiation.•Crosstalk between macrophage-secreted CXCL10 CXCR3 on Tregs induced GBC mutations. Background & AimsOur previous genomic whole-exome sequencing (WES) data...
Mitochondrial homeostasis is of great importance for cartilage integrity and associated with the progression osteoarthritis (OA); however, underlying mechanisms are unknown. This study aims to investigate role mitochondrial deacetylation reaction mechanistic relationship OA development. Silent mating type information regulation 2 homolog 3 (SIRT3) expression has a negative correlation severity in both human arthritic mice inflammatory chondrocytes. Global SIRT3 deletion accelerates...
The rational design of multifunctional biomaterials with hierarchical porous structure and on-demand biological activity is great consequence for bone tissue engineering (BTE) in the contemporary world. advanced combination trace element cerium ions (Ce3+) repair materials makes composite material capable promoting angiogenesis enhancing osteoblast activity. Herein, a living phosphorylated injectable hydrogel microsphere (P-GelMA-Ce@BMSCs) constructed by microfluidic technology coordination...
Objectives Patients with gallbladder carcinoma (GBC) lack effective treatment methods largely due to the inadequacy of both molecular characterisation and potential therapeutic targets. We previously uncovered a spectrum genomic alterations identified recurrent mutations in ErbB pathway GBC. Here, we aimed study genes pathways larger cohort patients GBC investigate mechanisms clinical significance these mutations. Design performed whole-exome sequencing (WES) 157 Functional experiments were...
Abstract Osteoarthritis (OA) is a common articular degenerative disease characterized by loss of cartilage matrix and subchondral bone sclerosis. Kartogenin (KGN) has been reported to improve chondrogenic differentiation mesenchymal stem cells. However, the therapeutic effect KGN on OA-induced degeneration was still unclear. This study aimed explore protective effects underlying mechanisms degradation using mice with post-traumatic OA. To mimic in vivo arthritic environment, vitro cultured...
Spatially resolved transcriptomics (SRT) technology enables us to gain novel insights into tissue architecture and cell development, especially in tumors. However, lacking computational exploitation of biological contexts multi-view features severely hinders the elucidation heterogeneity. Here, we propose stMVC, a graph collaborative-learning model that integrates histology, gene expression, spatial location, analyzing SRT data by attention. Specifically, stMVC adopting semi-supervised...
Reconstruction of osteochondral (OC) defects represents an immense challenge due to the need for synchronous regeneration special stratified tissues. The revolutionary innovation bioprinting provides a robust method precise fabrication tissue-engineered OCs with hierarchical structure; however, their spatial living cues simultaneous fulfilment osteogenesis and chondrogenesis reconstruct cartilage-bone interface OC are underappreciated. Here, inspired by natural bilayer features, anisotropic...
Cartilage injury represents a frequent dilemma in clinical practice owing to its inherently limited self-renewal capacity. Biomimetic strategy-based engineered biomaterial, capable of coordinated regulation for cellular and microenvironmental crosstalk, provides an adequate avenue boost cartilage regeneration. The level oxidative stress microenvironments is verified be vital tissue regeneration, yet it often overlooked biomaterials Herein, inspired by natural architecture, fibril-network...
Gallbladder cancer (GBC), highly aggressive form of with an extremely poor prognosis, is the most common malignancy biliary tract.In this study, we investigated effects dioscin (DSN) on human GBC and potential mechanisms underlying these effects.The results showed that DSN significantly inhibited cell proliferation migration.Moreover, induced apoptosis via mitochondrial dependent apoptotic signalling.Reactive oxygen species (ROS) glutathione (GSH) levels were measured, ROS scavengers...
Patients with metastatic or relapsed gallbladder cancer generally have a poor prognosis. Therefore, targeting metastasis is one arm of therapeutic strategies to treat cancer.Levels translationally controlled tumor protein (TCTP) were measured in samples by immunohistochemical staining. Wound healing, migration and invasion assays used investigate the motility cells. Western blot assay was levels TCTP other proteins. Liver models lung established inhibitory effect Dihydroartemisinin on...
Cholangiocarcinoma (CCA) is the most common biliary tract malignancy in world with high resistance to current chemotherapies and extremely poor prognosis. The main objective of this study was investigate inhibitory effects cryptotanshinone (CTS), a natural compound isolated from Salvia miltiorrhiza Bunge, on CCA both vitro vivo explore underlying mechanisms CTS-induced apoptosis cell cycle arrest.The anti-tumor activity CTS HCCC-9810 RBE cells assessed by...
This paper focuses on power distribution systems with inverter-interfaced renewable energy sources (RESs), and develops a distributed control framework to steer the RES output powers solutions of ac optimal flow (OPF) problems. The design algorithm is based suitable linear approximation power-flow equations, leverages so-called alternating direction method multipliers (ADMM). Convergence RES-inverter approximate OPF problem established under conditions mismatches between commanded setpoints...
Recent evidence indicates that the mitochondrial functions of chondrocytes are impaired in pathogenesis osteoarthritis (OA). Melatonin can attenuate cartilage degradation through its antioxidant functions. This study aims to investigate whether melatonin could rescue OA and protect metabolism. showed a compromised matrix synthesis capacity associated with dysfunction aberrant oxidative stress. In vitro treatments promoted expression extracellular (ECM) components, improved adenosine...
Full-range therapeutic regimens for osteoarthritis (OA) should consider organs (joints)-tissues (cartilage)-cells (chondrocytes)-organelles cascade, of which the subcellular mitochondria dominate eukaryotic cells' fate, and thus causally influence OA progression. However, dynamic regulation mitochondrial rise demise in impaired chondrocytes exact role metronome sirtuins 3 (SIRT3) is not clarified. Herein, are treated with SIRT3 natural agonist dihydromyricetin (DMY) or chemical antagonist...
Recent evidence suggests that dysregulated eIF3d expression may be critical in various genetic disorders as well cancer. In this study, we observed EIF3d levels increased gallbladder cancer (GBC) samples compared with non-tumor tissue. High were associated advanced tumor stage and metastasis correlated poor prognosis 92 patients GBC. Depletion of GBC cell lines inhibited proliferation, colony formation induced apoptosis cycle arrest vitro vivo. contrast, ectopic had the opposite effects....
Reactive oxygen species (ROS) are implicated in induction of inflammatory response and cartilage degradation osteoarthritis (OA). Melatonin has been shown to improve the chondrogenic differentiation promote matrix synthesis mesenchymal stem cells. However, underlying mechanisms melatonin-regulated antioxidant activity OA not known. The aim this study was explore effect melatonin on nuclear factor-erythroid 2-related factor 2 (NRF2), a key transcription factor, its target genes early-stage...
Osteoarthritis (OA) is characterized by the progressive destruction of articular cartilage, which involved in imbalance between extracellular matrix (ECM) synthesis and degradation. MicroRNA-140-5p (miR-140) specifically expressed cartilage plays an important role OA-induced The aim this study was to investigate (1) whether intra-articular injection melatonin could ameliorate surgically induced OA mice (2) regulate matrix-degrading enzymes at posttranscriptional level targeting miR-140. In...