A5061540304- Genetics, Aging, and Longevity in Model Organisms
- Growth Hormone and Insulin-like Growth Factors
- Pituitary Gland Disorders and Treatments
- Spaceflight effects on biology
- Diet and metabolism studies
- Metabolism, Diabetes, and Cancer
- Fibroblast Growth Factor Research
- DNA and Nucleic Acid Chemistry
- Circadian rhythm and melatonin
- Birth, Development, and Health
- Insurance, Mortality, Demography, Risk Management
- Digestive system and related health
- Health disparities and outcomes
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
University of Chicago
2021-2022
Albert Einstein College of Medicine
2020-2021
Washington University in St. Louis
2015-2017
Duke University
2016
Abstract Ageing generates senescent pathologies, some of which cause death. Interventions that delay or prevent lethal pathologies will extend lifespan. Here we identify life-limiting in Caenorhabditis elegans with a necropsy analysis worms have died old age. Our results imply the presence multiple causes Specifically, two classes corpse: early deaths swollen pharynx (which call ‘P deaths’), and later an atrophied (termed ‘p deaths’). The effects interventions on lifespan can be broken down...
While the growth hormone/insulin-like factor-1 (GH/IGF-1) pathway plays essential roles in and development, diminished signaling via this model organisms extends lifespan health-span. In humans, circulating IGF-1 IGF-binding proteins 3 1 (IGFBP-3 1), surrogate measures of GH/IGF-1 system activity, have not been consistently associated with morbidity mortality. a prospective cohort independently-living older adults (n = 840, mean age 76.1 ± 6.8 years, 54.5% female, median follow-up 6.9...
Abstract While insulin‐like growth factor‐1 (IGF‐1) is a well‐established modulator of aging and longevity in model organisms, its role humans has been controversial. In this study, we used the UK Biobank ( n = 440,185) to resolve previous ambiguities relationship between serum IGF‐1 levels clinical disease. We examined prospective associations with mortality, dementia, vascular disease, diabetes, osteoporosis, cancer, finding two generalized patterns: First, interacts age modify risk manner...
Using longitudinal data from a cohort of 1349 participants in the Framingham Heart Study, we show that as early 28–38 years age, almost 10% variation future lifespan can be predicted simple clinical parameters. Specifically, found diastolic and systolic blood pressure, glucose, weight, body mass index (BMI) to relevant lifespan. These similar parameters have been well-characterized risk factors relatively narrow context cardiovascular disease mortality middle old age. In contrast,...
A novel PDMS-hydrogel binding chemistry traps many individual<italic>C. elegans</italic>on a solid surface for lifelong culture and imaging.