A5004223318- Genetics, Aging, and Longevity in Model Organisms
- Circadian rhythm and melatonin
- Aging and Gerontology Research
- Tumors and Oncological Cases
- Prenatal Screening and Diagnostics
- Birth, Development, and Health
- Spaceflight effects on biology
- Teratomas and Epidermoid Cysts
Gansu Provincial Maternal and Child Health Hospital
2024
University College London
2017-2021
MRC Unit for Lifelong Health and Ageing
2017-2018
Abstract Ageing generates senescent pathologies, some of which cause death. Interventions that delay or prevent lethal pathologies will extend lifespan. Here we identify life-limiting in Caenorhabditis elegans with a necropsy analysis worms have died old age. Our results imply the presence multiple causes Specifically, two classes corpse: early deaths swollen pharynx (which call ‘P deaths’), and later an atrophied (termed ‘p deaths’). The effects interventions on lifespan can be broken down...
A long-standing belief is that aging (senescence) the result of stochastic damage accumulation. Alternatively, senescent pathology may also from late-life, wild-type gene action (i.e., antagonistic pleiotropy, as argued by Williams) leading to non-adaptive run-on developmental programs (or quasi-programs) (as suggested more recently Blagosklonny). In this study, we use existing and new data show how uterine tumors, a prominent form in nematode Caenorhabditis elegans, likely quasi-programs....
Abstract Differences in genetic background model organisms can have complex effects on phenotypes of interest. We previously reported a difference hermaphrodite lifespan between two wild-type lines widely used by C. elegans researchers (N2 and male stocks). Here, using pathology-based approaches genome sequencing, we identify the cause this as nonsense mutation filamin gene fln-2 stock, which reduces early mortality caused pharyngeal infection. show how variation explains previous...
Abstract In aging Caenorhabditis elegans , as in higher organisms, there is more than one cause of death. C . exhibit early death with a swollen, infected pharynx (P death), and later pharyngeal atrophy (p death). Interventions that alter lifespan can differentially affect frequency timing each type death, generating complex survival curve shapes. Here, we use mortality deconvolution analysis to investigate how reduction insulin/IGF‐1 signaling (IIS), which increases (the Age phenotype),...
Abstract Many diseases whose frequency increases with advancing age are caused by aging (senescence), but the mechanisms of senescence remain poorly understood. According to G.C. Williams and M.V. Blagosklonny, a major etiological determinant is late-life, wild-type gene action non-adaptive execution biological programs (or quasi-programs). These generate wide range senescent pathologies causing illness death. Here we investigate etiology prominent pathology in nematode C. elegans , uterine...