A5042019250- Genetics, Aging, and Longevity in Model Organisms
- Evolution and Genetic Dynamics
- Circadian rhythm and melatonin
- RNA and protein synthesis mechanisms
- Mitochondrial Function and Pathology
- Gut microbiota and health
- Cancer, Hypoxia, and Metabolism
- COVID-19 Clinical Research Studies
- RNA modifications and cancer
- DNA Repair Mechanisms
- SARS-CoV-2 and COVID-19 Research
- Redox biology and oxidative stress
- Chromosomal and Genetic Variations
- Evolutionary Game Theory and Cooperation
- Cancer, Lipids, and Metabolism
- Light effects on plants
- Aging and Gerontology Research
- Mobile Health and mHealth Applications
- Electronic Health Records Systems
- Inflammatory Bowel Disease
- Ecosystem dynamics and resilience
- Cancer-related Molecular Pathways
- 3D Printing in Biomedical Research
- Berberine and alkaloids research
- Eosinophilic Esophagitis
Kings Health Partners
2023-2025
University College London
2018-2024
HealthPartners
2023
Hammersmith Hospital
2021
Imperial College London
2021
MRC Unit for Lifelong Health and Ageing
2018-2021
MRC London Institute of Medical Sciences
2019-2021
Lomonosov Moscow State University
2007-2014
Engelhardt Institute of Molecular Biology
2014
Moscow State University
2010
Loss of proteostasis is a fundamental process driving aging. Proteostasis affected by the accuracy translation, yet physiological consequence having fewer protein synthesis errors during multi-cellular organismal aging poorly understood. Our phylogenetic analysis RPS23, key in ribosomal decoding center, uncovered lysine residue almost universally conserved across all domains life, which replaced an arginine small number hyperthermophilic archaea. When introduced into eukaryotic RPS23...
P66shc is a gene that regulates the level of reactive oxygen species (ROS), apoptosis induction, and lifespan in mammals. Mice knocked out for p66shc have ~30% longer demonstrate an enhanced resistance to oxidative stress age-related pathologies such as hypercholesterolemia, ischemia, hyperglycemia. In this respect, promising pharmacological target treatment diseases. review, attempt has been made survey put critical analysis data concerning involvement different signaling pathways regulate...
A long-standing belief is that aging (senescence) the result of stochastic damage accumulation. Alternatively, senescent pathology may also from late-life, wild-type gene action (i.e., antagonistic pleiotropy, as argued by Williams) leading to non-adaptive run-on developmental programs (or quasi-programs) (as suggested more recently Blagosklonny). In this study, we use existing and new data show how uterine tumors, a prominent form in nematode Caenorhabditis elegans, likely quasi-programs....
Abstract Background In the evolution from unicellular to multicellular life forms, natural selection favored reduced cell proliferation and even programmed death if this increased organismal fitness. Could individual fertility or similarly increase fitness of colonies closely-related metazoan organisms? This possibility is at least consistent with evolutionary theory, has been supported by computer modelling. Caenorhabditis elegans a boom bust history, where populations nematodes that are...
Abstract During aging, etiologies of senescence cause multiple pathologies, leading to morbidity and death. To understand aging requires identification these etiologies. For example, Caenorhabditis elegans hermaphrodites consume their own intestinal biomass support yolk production, which in later life drives atrophy ectopic deposition. Yolk proteins (YPs; vitellogenins) exist as three abundant species: YP170, derived from vit-1–vit-5; YP115 YP88, vit-6. Here, we show that inhibiting YP170...
Abstract In the nematode Caenorhabditis elegans , loss of function many genes leads to increases in lifespan, sometimes a very large magnitude. Could this reflect occurrence programmed death that, like apoptosis cells, promotes fitness? The notion that evolves as mechanism remove worn out, old individuals order increase food availability for kin is not supported by classic evolutionary theory most species. However, it may apply organisms with colonies closely related such C. which largely...
Standard evolutionary theory, supported by mathematical modelling of outbred, dispersed populations predicts that ageing is not an adaptation. We recently argued in clonal, viscous populations, programmed organismal death could promote fitness through social benefits and has, some organisms (e.g. Caenorhabditis elegans ), evolved to shorten lifespan. Here, we review previous adaptive including consumer sacrifice, biomass sacrifice defensive types altruistic death. In addition, discuss...
p66shc is a protein product of an mRNA isoform SHC1 gene that has pro-oxidant and pro-apoptotic activity implicated in the aging process. Mitochondria were suggested as major source p66shc-mediated production reactive oxygen species (ROS), although underlying mechanisms are poorly understood. We studied effects on oxidative stress induced by hydrogen peroxide or serum deprivation human colon carcinoma cell line RKO diploid dermal fibroblasts (HDFs). An shRNA-mediated knockdown suppressed...
Caenorhabditis elegans has become a key model organism within biology. In particular, the transparent gut, rapid growing time, and ability to create defined gut microbiota make it an ideal candidate for understanding engineering host microbiota. Here we present development of experimental that can be used characterize whole-cell bacterial biosensors in vivo. A dual-plasmid sensor system responding isopropyl β-d-1-thiogalactopyranoside was developed fully characterized vitro. Subsequently,...
Organismal death is a process of systemic collapse whose mechanisms are less well understood than those cell death. We previously reported that in C. elegans accompanied by calcium-propagated wave intestinal necrosis, marked blue autofluorescence (death fluorescence). Here, we describe another feature organismal death, body wall muscle contraction, or contraction (DC). This phenomenon intramuscular Ca2+ release and, subsequently, necrosis. Correlation directions the DC and necrosis waves...
Abstract In aging Caenorhabditis elegans , as in higher organisms, there is more than one cause of death. C . exhibit early death with a swollen, infected pharynx (P death), and later pharyngeal atrophy (p death). Interventions that alter lifespan can differentially affect frequency timing each type death, generating complex survival curve shapes. Here, we use mortality deconvolution analysis to investigate how reduction insulin/IGF‐1 signaling (IIS), which increases (the Age phenotype),...
Background We assessed the effectiveness of sotrovimab vs no early COVID-19 treatment in highest-risk patients during Omicron predominance. Methods Retrospective cohort study using Discover dataset North West London. Included were non-hospitalised, aged ≥12 years and met ≥1 National Health Service criterion for treatment. used Cox proportional hazards models to compare HRs 28-day COVID-19-related hospitalisation/death between sotrovimab-treated untreated patients. Age, renal disease...
Abstract Introduction There is uncertainty regarding how in vitro antibody neutralisation activity translates to the clinical efficacy of sotrovimab against severe acute respiratory syndrome coronavirus 2, although real-world evidence has demonstrated continued effectiveness during both BA.2 and BA.5 predominance. We previously reported descriptive results from Discover dataset for patients treated with sotrovimab, nirmatrelvir/ritonavir or molnupiravir, at highest risk per National Health...
C. elegans is an established model organism for studying genetic and drug effects on aging, many of which are conserved in humans. It also important basic research, pathologies a new emerging field. Here we develop proof-of-principal convolutional neural network-based platform to segment extract features that might be useful lifespan prediction. We use dataset 734 worms tracked throughout their classify into long-lived short-lived. designed WormNet - network (CNN) predict the worm class...
ObjectivesThe recent census found that five million people in England and Wales provide unpaid care. With social services struggling, carers face increasing pressure. The North West London Networked Data Lab aimed to understand carers’ needs, health issues, care pathways through public involvement analysis of linked datasets.
 MethodsWe used the Discover dataset containing primary, secondary, mental health, data 2.5 Londoners explore our aims. To ensure questions asked mattered locally,...