A5082809410- Virus-based gene therapy research
- Liver physiology and pathology
- Medication Adherence and Compliance
- COVID-19 Clinical Research Studies
- Heart Failure Treatment and Management
- SARS-CoV-2 and COVID-19 Research
- Viral Infectious Diseases and Gene Expression in Insects
- Skin and Cellular Biology Research
- Cancer Research and Treatments
- Estrogen and related hormone effects
- RNA Interference and Gene Delivery
- Genomics and Chromatin Dynamics
- Cancer Cells and Metastasis
- Digestive system and related health
- HER2/EGFR in Cancer Research
- Retinoids in leukemia and cellular processes
- PI3K/AKT/mTOR signaling in cancer
- Respiratory and Cough-Related Research
- Mobile Health and mHealth Applications
- Pediatric health and respiratory diseases
- Heparin-Induced Thrombocytopenia and Thrombosis
- Chronic Disease Management Strategies
- Peripheral Artery Disease Management
- Health Systems, Economic Evaluations, Quality of Life
- Herpesvirus Infections and Treatments
Kings Health Partners
2020-2024
HealthPartners
2020-2023
Imperial College London
2004-2022
King's College London
1989-2012
King's College Hospital NHS Foundation Trust
2012
Queen Mary University of London
2011
University College London
1991-2010
London Cancer
2010
CRUK Lung Cancer Centre of Excellence
2010
Nanjing Medical University
2005
Objective To describe characteristics and acute clinical outcomes for patients with COVID-19 treated sotrovimab, nirmatrelvir/ritonavir or molnupiravir, untreated at highest risk per National Health Service (NHS) criteria.
ABSTRACT The mammary gland is a renewing tissue in which morphogenetic processes and differentiation occur cyclically during the menstrual cycle, pregnancy lactation. These events have been shown to be dependent upon epithelial-mesenchymal interactions. Studies of effects individual factors, their cellular source target cell populations different developmental stages are greatly facilitated by accessibility this organ application new techniques that allow purification major epithelial...
brk (breast tumor kinase) shows homology to the src family of non-receptor protein-tyrosine kinases and is expressed in breast carcinomas. In order investigate role development, we have examined growth transformation properties human mammary epithelial cells engineered overexpress Brk. Interestingly, like c-Src, overexpression Brk leads sensitization EGF, also results a partially transformed phenotype. Further investigation latter activity was attempted by mutational analysis, targeting key...
The regulation of gene expression by estrogen receptor-α (ERα) requires the coordinated and temporal recruitment diverse sets transcriptional co-regulator complexes, which mediate nucleosome remodelling histone modification. Using ERα as bait in a yeast two-hybrid screen, we have identified novel ERα-interacting protein, ZNF366, is potent corepressor activity. interaction between ZNF366 has been confirmed vitro vivo, mediated zinc finger domains two proteins. Further, show that acts...
Abstract Introduction There is limited real-world evidence surrounding the effectiveness of early, mild-to-moderate COVID-19 treatments following emergence and dominance Omicron SARS-CoV-2 subvariants. Here, characteristics acute clinical outcomes are described for patients with treated sotrovimab, nirmatrelvir/ritonavir or molnupiravir, at highest risk per NHS criteria but who were untreated. Methods Retrospective cohort study non-hospitalised received early treatment for, diagnosed with,...
Chronic cough (CC) is a debilitating respiratory symptom, now increasingly recognised as discrete disease entity. This study evaluated the burden of CC in primary care setting.Cross-sectional, retrospective cohort study.Discover dataset from North West London, which links coded data and secondary care. The index date depicted persisting for ≥8 weeks was taken surrogate diagnosis.Data were extracted individuals aged ≥18 years with or remedy prescription, between Jan 2015 Sep 2019.Demographic...
Background We assessed the effectiveness of sotrovimab vs no early COVID-19 treatment in highest-risk patients during Omicron predominance. Methods Retrospective cohort study using Discover dataset North West London. Included were non-hospitalised, aged ≥12 years and met ≥1 National Health Service criterion for treatment. used Cox proportional hazards models to compare HRs 28-day COVID-19-related hospitalisation/death between sotrovimab-treated untreated patients. Age, renal disease...
Most patients with heart failure (HF) are diagnosed following a hospital admission. The clinical and health economic impacts of index HF diagnosis made on admission to versus community settings not known.We used the North West London Discover database examine 34 208 receiving an between January 2015 December 2020. A propensity score-matched (PSM) cohort was identified adjust for differences in socioeconomic status, cardiovascular risk pre-diagnosis resource utilisation cost. Outcomes were...
The prevalence of Diabetic Kidney Disease (DKD) secondary to Type 2 Diabetes Mellitus (T2DM) is rising worldwide. However, real-world data linking glomerular function and albuminuria the degree multi-morbidity lacking. We thus utilised Discover dataset, determine this association.Patients with T2DM diagnosed prior 1st January 2015 no available biochemical evidence CKD were included. Patients subsequently coded for CKD3a in 2015, grouped by albuminuria. Baseline 5-year co-morbidity was...
With 20-40% of patients who have inflammatory bowel disease (IBD) not responding to therapy, resource use and costs can be high. We performed a descriptive analysis health-care data for IBD management in the National Health Service explore potential areas improvement.
SUMMARY We report the identification and characterization of a clone for DNA binding protein SON , which we have isolated from human keratinocyte cDNA library. Using this found that gene is expressed in different cell types homologous sequences can be detected vertebrate insect genomic DNA. polymerase chain reaction (PCR) to amplify panel somatic hybrids assigned encoding chromosome 21. By use containing regions 21 localization has been refined 21q 22. 1‐q22.2.
To isolate recombinant antibodies with specificity for human arthritic synovium and to develop targeting reagents joint-specific delivery capacity therapeutic and/or diagnostic applications.In vivo single-chain Fv (scFv) antibody phage display screening using a synovial xenograft model was used specific the microvasculature of synovium. Single-chain tissue-specific reactivity assessed by immunostaining tissues from normal controls patients rheumatoid arthritis osteoarthritis, tissue arrays,...
ABSTRACT Scatter factor/hepatocyte growth factor (SF/HGF) is a multifunctional cytokine produced by embryonic fibroblasts and other mesenchymal cells that affects the and/or movement of certain epithelia. Here we report expression scatter activity MRC 5 cells, strain normal human lung fibroblasts, greatly reduced as result co-culture these with SVK14, an SV40-transformed kératinocyte cell line. Using cDNA probe to βchain HGF, have found fall in SF 5/SVK14 co-cultures accompanied loss SF/HGF...
Abstract Purpose: Oncolytic herpes simplex virus type 1 (HSV-1) vectors show considerable promise as agents for cancer therapy. We have developed a novel recombinant HSV-1 (JS1/34.5−/47−) purging of occult breast cells from bone marrow patients. Here, we evaluate the therapeutic efficacy this oncolytic virus. Experimental Design: Electron microscopy was used to determine whether human and are permissive JS1/34.5−/47− infection. Subsequently, biological effects infection on were established...
Background Despite effective therapies, the economic burden of heart failure with reduced ejection fraction (HFrEF) is driven by frequent hospitalizations. Treatment optimization and admission avoidance rely on symptom reviews monitoring vital signs. Remote (RM) aims to prevent admissions facilitating early intervention, but impact noninvasive, smartphone-based RM signs secondary health care use costs in months after a new diagnosis HFrEF unknown. Objective The purpose this study conduct...
ABSTRACT A comparison of normal epithelial cells with their transformed counterparts could lead to the definition parameters related growth and differentiation which are altered by viral transformation may be relevant malignant changes in vivo. Using SV40-transformed human keratinocyte line, SVK14, exhibits characteristics simple, nonkeratinizing epithelia, we have shown that IGF I stimulation these results extensive multilayering, increased cell size, accumulation involucrin, modulation...