A5016247746- Antibiotic Use and Resistance
- Osteoarthritis Treatment and Mechanisms
- Malaria Research and Control
- Mosquito-borne diseases and control
- Travel-related health issues
- Antibiotic Resistance in Bacteria
- Urinary Tract Infections Management
- Toxic Organic Pollutants Impact
- Pneumonia and Respiratory Infections
- Tendon Structure and Treatment
- Pharmaceutical Practices and Patient Outcomes
- Innovations in Medical Education
- Effects and risks of endocrine disrupting chemicals
- Protease and Inhibitor Mechanisms
- Digital Mental Health Interventions
- Mobile Health and mHealth Applications
- Cardiac, Anesthesia and Surgical Outcomes
- Bacterial Identification and Susceptibility Testing
- Antibiotics Pharmacokinetics and Efficacy
- Infections and bacterial resistance
- Enterobacteriaceae and Cronobacter Research
- Thyroid Disorders and Treatments
- Curcumin's Biomedical Applications
- Pharmacological Effects of Medicinal Plants
- Proteoglycans and glycosaminoglycans research
Université Clermont Auvergne
2022
Imperial College London
2014-2019
NIHR Imperial Biomedical Research Centre
2016-2019
National Institute for Health Research
2016
Royal Conservatory of Liège
2015
Hammersmith Hospital
2015
Sirris
2013-2014
Imperial College Healthcare NHS Trust
2014
Université Paris Cité
2012-2013
Mère et Enfant en Milieu Tropical
2013
Human exposure to polybrominated diphenyl ether (PBDE) flame retardants has increased exponentially over the last three decades. Animal and human studies suggest that PBDEs may disrupt thyroid function. Although hormone (TH) of maternal origin plays an essential role in normal fetal brain development, there is a paucity data regarding associations between TH levels during pregnancy.Our goal was determine whether PBDE serum concentrations are associated with pregnant women.We measured...
During the last decades, dengue viruses have spread throughout Americas region, with an increase in number of severe forms dengue. The surveillance system Guadeloupe (French West Indies) is currently operational for detection early outbreaks goal study was to improve this by assessing a modelling tool predict occurrence epidemics few months ahead and thus help efficient control. Box-Jenkins approach allowed us fit Seasonal Autoregressive Integrated Moving Average (SARIMA) model incidence...
Abstract Objective To evaluate the association between antibiotic treatment for urinary tract infection (UTI) and severe adverse outcomes in elderly patients primary care. Design Retrospective population based cohort study. Setting Clinical Practice Research Datalink (2007-15) care records linked to hospital episode statistics death England. Participants 157 264 adults aged 65 years or older presenting a general practitioner with at least one diagnosis of suspected confirmed lower UTI from...
Objectives To investigate the teaching of antimicrobial stewardship (AS) in undergraduate healthcare educational degree programmes United Kingdom (UK). Participants and Methods Cross-sectional survey human veterinary medicine, dentistry, pharmacy nursing UK. The main outcome measures included prevalence AS teaching; principles taught; estimated hours apportioned; mode content delivery strategies; evaluation methodologies; frequency multidisciplinary learning. Results 80% (112/140) responded...
Objective To describe characteristics and acute clinical outcomes for patients with COVID-19 treated sotrovimab, nirmatrelvir/ritonavir or molnupiravir, untreated at highest risk per National Health Service (NHS) criteria.
The management of osteoarthritis (OA) remains a challenge. There is need not only for safe and efficient treatments but also accurate reliable biomarkers that would help diagnosis monitoring both disease activity treatment efficacy. Curcumin basically spice known its anti-inflammatory properties. In vitro studies suggest curcumin could be beneficial cartilage in OA. aim this exploratory, non-controlled clinical trial was to evaluate the effects bio-optimized knee OA patients on serum levels...
The National Health Service England, Commissioning for Quality and Innovation Antimicrobial Resistance (CQUIN AMR) aims to reduce the total antibiotic consumption use of certain broad-spectrum antibiotics in secondary care. However, robust baseline data are lacking hospitalised children. In this study, we aim describe, compare explain prescription patterns within between paediatric units UK provide a prescribing future improvement using CQUIN AMR guidance.We conducted cross-sectional study...
Abstract Objective This study was undertaken to identify new biomarkers of osteoarthritis (OA) by proteomics analysis and develop specific immunoassays detect quantify them. Methods Proteomics performed in urine samples from 10 women (mean ± SD age 76.0 5.0 years) undergoing knee replacement surgery due severe OA 5 healthy 25.6 2.6 years). Protein content analyzed 2‐dimensional differential gel electrophoresis. spots that exhibited an OA:control abundance ratio ≥1.5 were identified mass...
Abstract Purpose To assess the impact of early sotrovimab treatment versus no on risk developing post-acute sequelae COVID-19 (PASC; long COVID) in patients (age ≥ 12 years) with at high for progression to severe disease. Methods Retrospective cohort study using US National COVID Cohort Collaborative (N3C) data. Phase 1 identified and assessed multiple definitions PASC; 2 evaluated effectiveness reducing PASC, utilizing from 1. Average effect treated (ATT)-weighted Cox proportional hazards...
Resistance to chloroquine (CQ) and sulphadoxine-pyrimethamine (SP) led the World Health Organization (WHO) recommend changes in national drug policies. The time between policy their implementation profoundly affects program impact. We developed a model based on data antimalarial treatments, extracted from household surveys information literature. Drug use each country during period 1999–2011 trend reduction of CQ after change were estimated. SP estimates correlated with prevalence molecular...
This study aimed to forecast the incidence rate of carbapenem resistance and assess impact an antimicrobial stewardship intervention using routine consumption surveillance data. Following outbreak OXA-48-producing Klebsiella pneumoniae (January 2008-April 2010) in a renal cohort London, forecasting ARIMA model was derived meropenem data [defined daily dose per 100 occupied bed-days (DDD/100OBD)] from 2005-2014 as predictor organisms (number new cases/year/100,000OBD). Interrupted times...
Objectives: To evaluate the impact of adding a mobile health (mHealth) decision support system for antibiotic prescribing to an established antimicrobial stewardship programme (ASP). Methods: In August 2011, policy was converted into application (app). A segmented regression analysis interrupted time series used assess app on indicators, using data (2008–14) from biannual point prevalence survey medical and surgical wards. There were six points pre-implementation post-implementation....
Appropriate antimicrobial prescribing is essential for patient care, yet up to half of prescriptions written in the UK are sub-optimal. Improving prescriber education has recently been promoted as a mechanism optimise use, but identification key learning objectives facilitate this so far lacking. Using qualitative methods we investigated junior doctor knowledge, attitudes, and behaviours around identify areas address future educational programmes. A cross-sectional survey qualified doctors...
ObjectivesWe examined the 4 year trend in antimicrobial susceptibilities and prescribing across levels of care at two London teaching hospitals their multisite renal unit, for surrounding community.
Chloroquine (CQ) was the main malaria therapy worldwide from 1940s until 1990s. Following emergence of CQ-resistant Plasmodium falciparum, most African countries discontinued use CQ, and now promote artemisinin-based combination as first-line treatment. This change generally initiated during last decade in West Central Africa. The aim this study is to describe changes CQ susceptibility region, using travellers returning region a sentinel system. conducted by Malaria National Reference...
Objectives Patient weight is a key measure for safe medication management and monitoring of patients. Here we report the recording patient's body on admission in three hospitals West London its relationship with prescription antibiotic drugs where it essential to have patient. Methods A prospective cross-sectional study was conducted teaching London. Data were collected during March 2011–September 2011 July 2012–August 2012, from adult admissions units, medical surgical wards. each ward...
We investigated chloroquine sensitivity to Plasmodium falciparum in travelers returning France and Canada from Haiti during a 23-year period. Two of 19 isolates obtained after the 2010 earthquake showed mixed pfcrt 76K+T genotype high 50% inhibitory concentration. Physicians treating malaria acquired should be aware possible resistance.
BackgroundCertain Clostridium difficile ribotypes have been associated with complex disease phenotypes including recurrence and increased severity, especially the well-described hypervirulent RT027. This study aimed to determine pattern of causing infection association, if any, severity.MethodsAll faecal samples submitted a large diagnostic laboratory for C. testing between 2011 2013 were subject routine culture. All isolates ribotyped, clinical demographic patient data retrieved linked...
Evidence indicates a relationship between obesity and infection. We assessed the prevalence of in hospitalized patients evaluated its impact on antimicrobial management.Three National Health Service hospitals London 2011-12 were included cross-sectional study. Data from all adult admissions units medical surgical wards collected. Patient data collected medication charts nursing notes. Antimicrobial therapy was defined as 'complicated' if patient's met two or more following criteria: (i)...