A5101629253- Antibiotic Use and Resistance
- Antibiotic Resistance in Bacteria
- Health Systems, Economic Evaluations, Quality of Life
- Pharmaceutical and Antibiotic Environmental Impacts
- Bacterial Identification and Susceptibility Testing
- Patient Satisfaction in Healthcare
- Urinary Tract Infections Management
- Pneumonia and Respiratory Infections
- Healthcare cost, quality, practices
- Salmonella and Campylobacter epidemiology
- Zoonotic diseases and public health
- Healthcare Policy and Management
- Animal Disease Management and Epidemiology
- Antimicrobial Resistance in Staphylococcus
- Healthcare Systems and Reforms
- Global Health Care Issues
- Global Maternal and Child Health
- Cardiac, Anesthesia and Surgical Outcomes
- Animal Behavior and Welfare Studies
- Mobile Health and mHealth Applications
- COVID-19 epidemiological studies
- Child Nutrition and Water Access
- Aquaculture disease management and microbiota
- Pharmaceutical Quality and Counterfeiting
- Enhanced Recovery After Surgery
London School of Hygiene & Tropical Medicine
2019-2024
UK Health Security Agency
2021-2024
Faculty of Public Health
2023
University of London
2023
Imperial College London
2016-2022
National Institute for Health Research
2016-2022
NIHR Imperial Biomedical Research Centre
2020
University of Oxford
2019
World Health Organization
2019
University of Geneva
2019
Klebsiella pneumoniae causes community- and healthcare-associated infections in children adults. Globally 2019, an estimated 1.27 million (95% Uncertainty Interval [UI]: 0.91-1.71) 4.95 UI: 3.62-6.57) deaths were attributed to associated with bacterial antimicrobial resistance (AMR), respectively. K. was the second leading pathogen AMR resistant bacteria. Furthermore, rise of both hospital-acquired is a concern for neonates infants who are at high risk invasive disease. There limited...
Introduction Antibiotic resistance poses a threat to public health and healthcare systems. Escherichia coli causes more bacteraemia episodes in England than any other bacterial species. This study aimed estimate the burden of E. associated antibiotic secondary care setting. Materials methods was retrospective cohort study, with as main exposure interest. Adult hospital in-patients, admitted acute NHS hospitals between July 2011 June 2012 were included. English national surveillance...
Introduction Limited information on costs and the cost-effectiveness of hospital interventions to reduce antibiotic resistance (ABR) hinder efficient resource allocation. Methods We conducted a systematic literature review for studies evaluating pharmaceutical non-pharmaceutical aimed at reducing, monitoring controlling ABR in patients. Articles published until 12 December 2023 were explored using EconLit, EMBASE PubMed. focused critical or high-priority bacteria, as defined by WHO,...
Abstract Background Qualitative work has described the differences in prescribing practice across medical and surgical specialties. This study aimed to understand if specialty impacts quantitative measures of practice. Methods We prospectively analysed antibiotic general teams for acutely admitted patients. Over a 12-month period (June 2016 – May 2017) 659 patients (362 medical, 297 surgical) were followed duration their hospital stay. Antibiotic these cohorts was assessed using Chi-squared...
Objectives COVID-19 has altered health sector capacity in low-income and middle-income countries (LMICs). Cost data to inform evidence-based priority setting are urgently needed. Consequently, this paper, we calculate the full economic costs of clinical management 79 LMICs under different epidemiological scenarios. Methods We used country-specific projections from a dynamic transmission model determine number cases, hospitalisations deaths over 1 year four mitigation defined response for...
Asymptomatic SARS-CoV-2 testing of hospitalised patients began in April-2020, with twice weekly healthcare worker (HCW) introduced November-2020. Guidance recommending asymptomatic was withdrawn August-2022. Assessing the impact this decision from data alone is challenging due to concurrent changes infection prevention and control practices, community transmission rates, a reduction ascertainment rate reduced testing. Computational modelling an effective tool for estimating change.
It is commonly asserted that agricultural production systems must use fewer antibiotics in food-producing animals order to mitigate the global spread of antimicrobial resistance (AMR). In assess cost-effectiveness such interventions, especially given potential trade-off with rural livelihoods, we quantify more precisely relationship between animal and AMR humans. Here, outline compare methods can be used estimate this relationship, calling on key literature area. Mechanistic mathematical...
Policy makers need to be rapidly informed about the potential equity consequences of different COVID-19 strategies, alongside their broader health and economic impacts. While there are complex models inform both macro-economic impact, few tools available assess impacts interventions.
Antimicrobial resistance (AMR), the capacity of microbial pathogens to survive in presence antimicrobials, is considered one greatest threats human health worldwide and growing rapidly importance. AMR thought be driven part by use antimicrobials (AMU) livestock production. AMU reduction agriculture therefore important, but doing so may endanger farmers' livelihoods hamper broader food security. Understanding drivers for antibiotics essential designing interventions which avoid harming...
Estimates of the burden antimicrobial resistance (AMR) are needed to ascertain AMR impact, evaluate interventions, and allocate resources efficiently. Recent studies have estimated health, cost, economic relating AMR, with outcomes interest ranging from drug-bug impact on mortality in a hospital setting total global economy. However, recent collation this information has been largely informal, no formal quality assessment current evidence base (e.g. predefined checklists). This review...
Abstract Background The global disease burden of Salmonella infections in 2017 included 135,900 deaths caused by Typhi and Paratyphi 77,000 invasive non-typhoidal , increasing antimicrobial resistance further exacerbates morbidity, mortality, costs. To address the evidence gap on economic resistant infections, our study aim is to estimate length hospital stay associated treatment costs for patients with susceptible or antibiotic-resistant Paratyphi, infections. Methods We conducted a...
Antimicrobial resistance (AMR), the capacity of microbial pathogens to survive in presence antimicrobials, is considered one greatest threats human health worldwide and growing rapidly importance. AMR thought be driven part by use antimicrobials (AMU) livestock production. AMU reduction agriculture therefore important, but doing so may endanger farmers’ incomes hamper broader food security. Understanding drivers for farmers' antibiotics essential designing interventions which avoid...