A5006009740- Bacterial Genetics and Biotechnology
- Vibrio bacteria research studies
- Antibiotic Resistance in Bacteria
- Poxvirus research and outbreaks
- Salmonella and Campylobacter epidemiology
- Drug Transport and Resistance Mechanisms
- Inflammatory Bowel Disease
- Single-cell and spatial transcriptomics
- T-cell and B-cell Immunology
- Immune responses and vaccinations
- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- Child Nutrition and Water Access
- Viral gastroenteritis research and epidemiology
- Immune Cell Function and Interaction
- Transgenic Plants and Applications
- Herpesvirus Infections and Treatments
- Biosimilars and Bioanalytical Methods
- Dermatology and Skin Diseases
- IL-33, ST2, and ILC Pathways
- Probiotics and Fermented Foods
- Bacterial biofilms and quorum sensing
AstraZeneca (United Kingdom)
2023-2025
Imperial College London
2020-2024
World Health Organization - Pakistan
2024
Medical Research Council
2022
University of Cambridge
2022
University of London
2016
Abstract Human NK cells are activated by cytokines, immune complexes, and signals transduced via activating ligands on other host cells. After vaccination, or during secondary infection, adaptive responses can enhance both cytokine-driven Ab-dependent cell responses. However, induction of for enhanced function after in vitro exposure to innate inflammatory cytokines has also been reported may synergize with potentiate activity infection vaccination. To test this hypothesis, we examined the...
Abstract Background Single-cell technologies enable the fine mapping of disease and treatment mechanisms in inflammatory bowel (IBD). We sought to leverage these insights discover novel drug targets with precise therapeutic hypotheses. To this end, we previously constructed one largest integrated single-cell atlas IBD patient-derived tissue samples1. then used Immunai’s ImmunoDynamics EngineTM, a proprietary machine learning (ML) framework, identify transcriptional signatures inflammation...
Pyruvate (CH3COCOOH) is the simplest of alpha-keto acids and at interface several metabolic pathways both in prokaryotes eukaryotes. In an amino acid-rich environment, fast-growing bacteria excrete pyruvate instead completely metabolizing it. The role uptake pathological conditions still unclear. this study, we identified two pyruvate-specific transporters, BtsT CstA, Salmonella enterica serovar Typhimurium (S. Typhimurium). Expression btsT induced by histidine kinase/response regulator...
Abstract Background The global disease burden of Salmonella infections in 2017 included 135,900 deaths caused by Typhi and Paratyphi 77,000 invasive non-typhoidal , increasing antimicrobial resistance further exacerbates morbidity, mortality, costs. To address the evidence gap on economic resistant infections, our study aim is to estimate length hospital stay associated treatment costs for patients with susceptible or antibiotic-resistant Paratyphi, infections. Methods We conducted a...
Abstract Background Advances in single-cell technologies enable the unbiased study of cellular heterogeneity. Recently, RNA sequencing (scRNA-seq) has been utilised on intestinal and blood samples from patients with inflammatory bowel disease (IBD) healthy individuals, often conjunction cell surface proteome TCR repertoire analyses. These individual studies revealed novel subpopulations immune, mesenchymal, epithelial cells UC CD, but are not sufficiently powered to consistently identify...
Vaccinia virus (VACV) protein N1 is an intracellular immunomodulator that contributes to virulence via inhibition of NF-κB. Intradermal infection with a VACV lacking gene N1L (vΔN1) results in smaller skin lesions than wild-type (WT VACV), but the impact deletion on local microbiota as well innate and cellular immune responses infected ear tissue mostly uncharacterized. Here, we analysed bacterial burden host response at site report presence correlated enhanced expansion microbiota, even...
SUMMARY Pyruvate (CH 3 COCOOH) is the simplest of alpha-keto acids and at interface several metabolic pathways both in prokaryotes eukaryotes. In an amino acid-rich environment, fast-growing bacteria excrete pyruvate instead completely metabolizing it. The role uptake pathological conditions still unclear. this study, we identified two pyruvate-specific transporters, BtsT CstA, Salmonella enterica serovar Typhimurium ( S . Typhimurium). Expression btsT induced by histidine kinase/response...