A5031988259- Antifungal resistance and susceptibility
- Inflammasome and immune disorders
- Immune Cell Function and Interaction
- Gut microbiota and health
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune responses and vaccinations
- Fungal Infections and Studies
- Immune cells in cancer
- Protein Degradation and Inhibitors
- Reproductive System and Pregnancy
- Signaling Pathways in Disease
- Eosinophilic Esophagitis
- Psoriasis: Treatment and Pathogenesis
- Monoclonal and Polyclonal Antibodies Research
- Inflammatory Bowel Disease
- Peptidase Inhibition and Analysis
- RNA Research and Splicing
- Phagocytosis and Immune Regulation
- Immunotherapy and Immune Responses
- Infections and bacterial resistance
- Spondyloarthritis Studies and Treatments
- Biosimilars and Bioanalytical Methods
- IL-33, ST2, and ILC Pathways
- RNA regulation and disease
- CRISPR and Genetic Engineering
AstraZeneca (United Kingdom)
2025
King's College London
2020-2021
Institut Pasteur
2018-2021
Université Paris Cité
2021
Sapienza University of Rome
2013-2014
Exposure of mononuclear phagocytes to β-glucan, a naturally occurring polysaccharide, contributes the induction innate immune memory, which is associated with long-term epigenetic, metabolic, and functional reprogramming. Although previous studies have shown that memory induced by β-glucan confers protection against secondary infections, its impact on autoinflammatory diseases, inflammasome activation IL-1β secretion, remains poorly understood. In particular, whether β-glucan-induced...
Candida albicans is a common opportunistic fungal pathogen that causes wide range of infections from superficial mucosal to hematogenously disseminated candidiasis. The hyphal form plays an important role in the pathogenic process by invading epithelial cells and causing tissue damage. Notably, secretion toxin candidalysin essential for both cell damage activation immune responses. However, mechanism candidalysin-induced death remains unclear. Here, we examined induction oral cells....
Abstract Background Single-cell technologies enable the fine mapping of disease and treatment mechanisms in inflammatory bowel (IBD). We sought to leverage these insights discover novel drug targets with precise therapeutic hypotheses. To this end, we previously constructed one largest integrated single-cell atlas IBD patient-derived tissue samples1. then used Immunai’s ImmunoDynamics EngineTM, a proprietary machine learning (ML) framework, identify transcriptional signatures inflammation...
Adenosine deaminases acting on RNA (ADARs) are key proteins for hematopoietic stem cell self-renewal and survival of differentiating progenitor cells. However, their specific role in myeloid maturation has been poorly investigated. Here we show that ADAR1 is present at basal level the primary leukemia cells obtained from patients diagnosis as well U-937 THP1 lines its expression correlates with editing levels. Upon phorbol-myristate acetate or Vitamin D3/granulocyte macrophage...
HLA-E is a nonclassical HLA-class I molecule whose best known role to protect from the natural killer cells. More recently, an additional function more similar that of classical molecules, i.e., antigen presentation T cells, emerging. However, much remains be explored about intracellular trafficking molecules. With use 3 different cellular contexts, 2 monocytic cell lines, U937 and THP1, peripheral blood monocytes, we show here remarkable increase during monocyte-macrophage differentiation....
Abstract Recognition of the fungal cell wall carbohydrate β‐glucan by host receptor Dectin‐1 elicits broad immunomodulatory responses, such as phagocytosis and activation oxidative burst. These responses are essential for engulfing killing pathogens. Phagocytic monocytes key mediators these early inflammatory to infection. Remarkably, whether leads an response in human remains be established. Here, we show that heat‐killed Candida albicans is trigger inflammation cytokine release. By...
Complex immune and neurodegenerative disorders are the result of multiple interactions between common genetic variations having, individually, a weak effect on disease susceptibility or resistance. Interestingly, some genes have been found to be associated with more than one although not necessarily same SNPs involved. In this context, single nucleotide polymorphisms in 3′UTR region type 1 receptor (VPAC-1) for vasoactive intestinal peptide (VIP) reported immune-mediated as well diseases...
Abstract In vitro , exposure of human primary monocytes to the fungal β-glucan enhances their pro-inflammatory responsiveness towards several pathogens. Yet, role environmental condition this process remains unclear. Here we found that β-glucan-induced innate immune memory counteract anti-inflammatory status macrophages. response imprinting, M-CSF-(M2-like-) macrophages increase secondary stimuli associated with decrease M-CSF differentiation hallmarks. contrast, in GM-CSF-(M1-like-)...
Event Abstract Back to Transcriptional regulation of the anti-inflammatory NLRP12/Monarch-1 by NF-kB Sinem Tuncer1*, Cristina Camperio1, Giorgio Camilli1, Nicla Porciello1, Enza Piccolella1, Maria Teresa Fiorillo1 and Rosa Sorrentino1 1 Sapienza University Rome, Italy NLRP12 (NLR family, pyrin domain containing 12) is a NLR (Nucleotide-binding leucine-rich repeat containing) protein which expressed predominantly in cells myeloid origin. It has been described as negative regulator both...
<h3>Background</h3> Ankylosing Spondylitis (AS) is a complex chronic inflammatory disease strongly associated with the majority of HLA-B27 alleles. HLA-E are non classical MHC class I molecules that specifically interact natural killer receptors NKG2A (inhibitory) and NKG2C (activating), have been recently proposed to be involved in AS pathogenesis. The two known variants differ only at position 128, either an arginine or glycine, this polymorphism has demonstrated relevant host immunity...
Event Abstract Back to Modulation of NKG2D and NKG2A ligands expression during monocyte differentiation Giorgio Camilli1*, Fabiana Paladini1, Antonino Cassotta1, Raffaella La Scaleia2, Simone Battella2, Maria Teresa Fiorillo1, Gabriella Palmieri2, Angela Santoni3, 4 Rosa Sorrentino1, 1 Sapienza University Rome, Dept Biology Biotechnology "C. Darwin", Italy 2 Experimental Medicine, 3 Molecular Istituto Pasteur - Fondazione Cenci Bolognetti, Natural killer cells macrophages are the major...