A5030708501- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- COVID-19 epidemiological studies
- Hepatitis B Virus Studies
- Trauma and Emergency Care Studies
- Health Systems, Economic Evaluations, Quality of Life
- Traumatic Brain Injury and Neurovascular Disturbances
- Child and Adolescent Psychosocial and Emotional Development
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Pandemic Impacts
- Healthcare Policy and Management
- Vaccine Coverage and Hesitancy
- Gastrointestinal Bleeding Diagnosis and Treatment
- Neurological disorders and treatments
- Neuroscience and Neural Engineering
- Complementary and Alternative Medicine Studies
- Cardiac pacing and defibrillation studies
- Efficiency Analysis Using DEA
- Topic Modeling
- Medicinal Plants and Bioactive Compounds
- Zoonotic diseases and public health
- Anesthesia and Sedative Agents
- Respiratory viral infections research
- Primary Care and Health Outcomes
- Otolaryngology and Infectious Diseases
London School of Hygiene & Tropical Medicine
1998-2024
Newcastle Dental Hospital
2024
University of London
2022
Purdue University West Lafayette
2019-2021
University College London
2019-2020
National Institute for Health Research
2019-2020
Center for Occupational Research and Development
1994
Royal London Hospital
1990
Queen Mary University of London
1990
Rusk Rehabilitation
1969-1972
Abstract There is conflicting evidence on the influence of weather COVID-19 transmission. Our aim to estimate weather-dependent signatures in early phase pandemic, while controlling for socio-economic factors and non-pharmaceutical interventions. We identify a modest non-linear association between mean temperature effective reproduction number (R e ) 409 cities 26 countries, with decrease 0.087 (95% CI: 0.025; 0.148) 10 °C increase. Early interventions have greater effect R 0.285 CI 0.223;...
Abstract England has experienced a heavy burden of COVID-19, with multiple waves SARS-CoV-2 transmission since early 2020 and high infection levels following the emergence spread Omicron variants late 2021. In response to rising cases, booster vaccinations were accelerated offered all adults in England. Using model fitted more than 2 years epidemiological data, we project potential dynamics infections, hospital admissions deaths December 2022. We consider key uncertainties including future...
Tranexamic acid safely reduces mortality in traumatic extracranial bleeding. Intracranial bleeding is common after brain injury and can cause herniation death. We assessed the effects of tranexamic patients.To assess on death, disability vascular occlusive events patients. also cost-effectiveness.Randomised trial economic evaluation. Patients were assigned by selecting a numbered treatment pack from box containing eight packs that identical apart number. Patients, caregivers those assessing...
The prevalence of hepatitis is high in emergency department (ED) attendees the United Kingdom, with a up to 2% for B (HBV) HBsAg, and 2.9% C (HCV) RNA. aim this paper perform an economic evaluation opt-out ED-based HCV HBV testing.A Markov model was developed analyze cost-effectiveness testing EDs UK. used data from UK studies ED parameterize (1.4% RNA, 0.84% HBsAg), test costs, intervention effects (contact rates linkage care). For HCV, we antibody cost £3.64 RNA £68.38, assumed...
Implantable closed-loop neuromodulation devices for use in long-term chronic studies a lab or clinical trial are expensive to acquire and difficult modify specific cases. This article documents the design fabrication of wireless implantable device using only commercially available off-the-shelf (COTS) components. device, called Bionode, can record transmit up four channels biopotential data while simultaneously providing biphasic constant-current stimulation. The Bionode is viable, low-cost,...
Abstract Objective To evaluate the effectiveness and cost of a complex intervention in primary care that aims to increase uptake hepatitis C virus (HCV) case finding treatment. Design Pragmatic, two armed, practice level, cluster randomised controlled trial economic evaluation. Setting participants 45 general practices South West England (22 23 control arm). Outcome data were collected from all 21/23 practices. Total number flagged patients was 24 473 (about 5% list). Intervention Electronic...
An estimated 69 million traumatic brain injuries (TBI) occur each year worldwide, with most in low-income and middle-income countries. The CRASH-3 randomised trial found that intravenous administration of tranexamic acid within 3 hours injury reduces head deaths patients sustaining a mild or moderate TBI. We examined the cost-effectiveness treatment for
Innovative testing approaches and care pathways are required to meet global hepatitis B virus (HBV) C (HCV) elimination goals. Routine blood-borne (BBV) in emergency departments (EDs) high-prevalence areas is suggested by the European Centre for Disease Prevention Control (ECDC) but there limited evidence this. Universal HIV our ED according UK guidance has been operational since 2015. We conducted a real-world service evaluation of modified electronic patient record (EPR) system include...
Imaging is increasingly used to capture information on the marine environment thanks improvements in imaging equipment, devices for carrying cameras and data storage recent years. In that context, biologists, geologists, computer specialists end-users must gather discuss methods procedures optimising quality quantity of collected from images. The 4 th Marine Workshop was organised 3-6 October 2022 Brest (France) a hybrid mode. More than hundred participants were welcomed person about 80...
Virtually all malaria infections seen in the United Kingdom (UK) recent years have been contracted overseas and imported into UK, apart from two cases 1976 due to infected mosquitoes occasional of congenital or transfusion
The global spread of coronavirus disease 2019 (COVID-19) has emphasized the need for evidence-based strategies safe operation schools during pandemics that balance infection risk with society’s responsibility allowing children to attend school. Due limited empirical data, existing analyses assessing school-based interventions in pandemic situations often impose strong assumptions, example, on relationship between class size and transmission risk, which could bias estimated effect...
Birth cohort screening for the hepatitis C virus (HCV) has been implemented in US, but there is little evidence of its cost-effectiveness England. We aim to evaluate one-time HCV individuals born between 1950 and 1979 as part National Health Service health check England, a adults aged 40 74 years primary care.A Markov model was developed analyze add-on testing birth cohorts 1979, versus current background only, over lifetime horizon. The used data from back-calculation burden sentinel...
We report a case of diabetic renal transplant patient with candiduria who developed repeated elevations in serum creatinine concentration due to an intermittently obstructing Candida ball the urinary tract. After unsuccessful attempts place nephrostomy tube for local irrigation and debulking, graft artery ruptured secondary extensive perirenal infection. Percutaneous may increase risks extrarenal tissue infection potential fatal complications such as vascular anastomosis.
Advanced health economic analysis techniques currently performed in Microsoft Excel, such as incorporating heterogeneity, time-dependent transitions and a value of information analysis, can be easily transferred to R. Often the outputs survival analyses (such Weibull regression models) will estimate impacts correlated patient characteristics on outcomes, are utilised directly inputs for decision models. This tutorial provides step-by-step guide how conduct with Markov model developed R,...
Objectives The majority (>90%) of new or undiagnosed cases hepatitis B virus (HBV) in the UK are among individuals born countries with intermediate high prevalence levels (≥2%). We evaluate cost-effectiveness increased HBV case-finding migrant populations, based on a one-time opt out approach primary care setting. Design Cost-effectiveness evaluation. A decision model Markov was built to assess progression infection and without treatment as result case-finding. parameters, including cost...
Background Tranexamic acid reduces blood loss in surgery and the risk of death trauma patients. Meta-analyses small trials suggest that tranexamic decreases number deaths from gastrointestinal bleeding, but these meta-analyses are prone to selection bias. Objective The trial provides reliable evidence effect on mortality, rebleeding complications significant acute bleeding. Design A multicentre, randomised, placebo-controlled economic analysis. Patients were assigned by selecting one...
Numerous studies have shown the effectiveness of testing for hepatitis B (HBV) and C (HCV) in emergency departments (ED), due to elevated prevalence amongst attendees. The aim this study was conduct a cost-effectiveness analysis universal opt-out HBV HCV EDs based on 2 long-term real-world large ED's UK.A Markov model used evaluate ED-based versus no ED testing, addition current practice. two had HBsAg 0.5-0.9% an RNA 0.9-1.0%. performed from UK health service perspective, over lifetime time...