David Hodgson
A5017721813- Respiratory viral infections research
- SARS-CoV-2 and COVID-19 Research
- COVID-19 epidemiological studies
- COVID-19 Clinical Research Studies
- Influenza Virus Research Studies
- Pneumonia and Respiratory Infections
- Asthma and respiratory diseases
- Respiratory Support and Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Viral gastroenteritis research and epidemiology
- Respiratory and Cough-Related Research
- Neonatal Respiratory Health Research
- Long-Term Effects of COVID-19
- COVID-19 and healthcare impacts
- SARS-CoV-2 detection and testing
- Glioma Diagnosis and Treatment
- vaccines and immunoinformatics approaches
- Adolescent and Pediatric Healthcare
- Intensive Care Unit Cognitive Disorders
- Monoclonal and Polyclonal Antibodies Research
- Nosocomial Infections in ICU
- Viral Infections and Immunology Research
- Inflammatory mediators and NSAID effects
- Vaccine Coverage and Hesitancy
- COVID-19 Digital Contact Tracing
London School of Hygiene & Tropical Medicine
2019-2025
University of London
2019-2022
Institut de Virologie
2022
University College London
2011-2021
University of Cambridge
2021
Oxford University Clinical Research Unit
2021
University of Dundee
2021
Medical Research Council
2021
NIHR Birmingham Biomedical Research Centre
2021
University of Birmingham
2021
Two new products for preventing Respiratory Syncytial Virus (RSV) in young children have been licensed: a single-dose long-acting monoclonal antibody (la-mAB) and maternal vaccine (MV). To facilitate the selection of RSV intervention programmes large-scale implementation, this study provides an assessment to compare costs potential with health benefits accrued. Using existing dynamic transmission model, we compared vaccination la-mAB therapy against England Wales by calculating impact...
Abstract Emerging evidence suggests that contact tracing has had limited success in the UK reducing R number across COVID-19 pandemic. We investigate potential pitfalls and areas for improvement by extending an existing branching process model, adding diagnostic testing refining parameter estimates. Our results demonstrate reporting adherence are most important predictors of programme impact but coverage speed plus sensitivity also play role. conclude well-implemented could bring small...
Abstract England has experienced a heavy burden of COVID-19, with multiple waves SARS-CoV-2 transmission since early 2020 and high infection levels following the emergence spread Omicron variants late 2021. In response to rising cases, booster vaccinations were accelerated offered all adults in England. Using model fitted more than 2 years epidemiological data, we project potential dynamics infections, hospital admissions deaths December 2022. We consider key uncertainties including future...
The emergence of successive Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) variants concern (VOCs) during 2020 to 2022, each exhibiting increased epidemic growth relative earlier circulating variants, has created a need understand the drivers such growth. However, both pathogen biology and changing host characteristics—such as varying levels immunity—can combine influence replication transmission SARS-CoV-2 within between hosts. Disentangling role variant in individual-level...
Influenza vaccine effectiveness and immunogenicity can be compromised with repeated vaccination. We assessed immunological markers in a cohort of healthcare workers (HCW) from six public hospitals around Australia during 2020-2021. Sera were collected pre-vaccination ~14 ~180 days post-vaccination haemagglutination inhibition assay against egg-grown equivalent cell-grown viruses. Responses to vaccination compared by the number prior vaccinations. Baseline sera available for 595 HCW 2020 1031...
Abstract Background With a suite of promising new RSV prophylactics on the horizon, including long-acting monoclonal antibodies and vaccines, it is likely that one or more these will replace current Palivizumab programme. However, choosing optimal intervention programme require balancing costs programmes with health benefits accrued. Methods To compare next generation prophylactics, we integrated novel transmission model an economic analysis. We estimated key epidemiological parameters by...
BackgroundRespiratory syncytial virus (RSV) represents a substantial burden of disease in young infants low-income and middle-income countries (LMICs). Because RSV passive immunisations, including maternal vaccination monoclonal antibodies, can only grant temporary period protection, their effectiveness efficiency will be determined by the timing immunisation relative to underlying seasonality. We aimed assess potential effect different approaches for LMICs.MethodsWe included 52 LMICs this...
We assess the feasibility of reaching herd immunity threshold against SARS-CoV-2 through vaccination, considering vaccine effectiveness (VE), transmissibility virus and level pre-existing in populations, as well their age structure. If highly transmissible variants concern become dominant areas with low levels naturally-acquired and/or populations large proportions < 15 year-olds, control infection without non-pharmaceutical interventions may only be possible a VE ≥ 80%, coverage extended to...
Abstract Little is known about SARS-CoV-2 infection risk in African countries with high levels of infection-driven immunity and low vaccine coverage. We conducted a prospective cohort study 349 participants from 52 households The Gambia between March 2021 June 2022, routine weekly RT-PCR 6-monthly serology. Attack rates 45% 57% were seen during Delta Omicron BA.1 waves respectively. Eighty-four percent RT-PCR-positive infections asymptomatic. Children under 5-years had lower incidence than...
ABSTRACT Understanding acute infectious disease dynamics at individual and population levels is critical for informing public health preparedness response. Serological assays, which measure a range of biomarkers relating to humoral immunity, can provide valuable window into immune responses generated by past infections vaccinations. However, traditional methods interpreting serological data, such as binary seropositivity seroconversion thresholds, often rely on heuristics that fail account...
Introduction Vaccination against COVID-19 has been pivotal in reducing the global burden of disease. However, Phase III trial results and observational studies underscore differences efficacy across vaccine technologies dosing regimens. Notably, mRNA vaccines have exhibited superior effectiveness compared to Adenovirus (AdV) vaccines, especially with extended intervals. Methods Using in-host mechanistic modelling, this study elucidates these variations unravels biological mechanisms shaping...
In 2013 England and Wales began to fund a live attenuated influenza vaccine programme for individuals aged 2-16 years. Mathematical modelling predicts substantial beneficial herd effects the entire population as result of reduced transmission. With decreased influenza-associated disease burden, existing immunisation programmes might be less cost-effective. The aim this study was assess epidemiological effect cost-effectiveness elderly risk group vaccination under new policy mass paediatric...
Forecasting healthcare demand is essential in epidemic settings, both to inform situational awareness and facilitate resource planning. Ideally, forecasts should be robust across time locations. During the COVID-19 pandemic England, it an ongoing concern that for hospital care patients England will exceed available resources.
Abstract The emergence of highly transmissible SARS-CoV-2 variants has created a need to reassess the risk posed by increasing social contacts as countries resume pre-pandemic activities, particularly in context resuming large-scale events over multiple days. To examine how formed different activity settings influences interventions required control Delta variant outbreaks, we collected high-resolution data on among passengers and crew cruise ships combined with network transmission models....
Background Peroxisome proliferator-activated receptor gamma (PPAR-γ) is a nuclear that modulates inflammation in models of asthma. To determine whether pioglitazone improves measures asthma control and airway inflammation, we performed single-center randomized, double-blind, placebo-controlled, parallel-group trial. Methods Sixty-eight participants with mild were randomized to 12 weeks (30 mg for 4 weeks, then 45 8 weeks) or placebo. The primary outcome was the adjusted mean forced...
Abstract Background In children aged <5 years in whom severe respiratory syncytial virus (RSV) episodes predominantly occur, there are currently no appropriate standardised instruments to estimate quality of life (QALY) loss. Objectives We estimated the age‐specific QALY loss due RSV by developing a regression model which predicts without use instruments. Methods conducted surveillance study targeted confirmed (confirmed cases) and their household members who experienced symptoms during...
Respiratory Syncytial Virus (RSV) is a major cause of acute lower respiratory tract infections (ALRI) in infants. There are no licensed vaccines and only one monoclonal antibody available to protect infants from disease. A new potentially longer-lasting antibody, Nirsevimab, showed promising results phase IIb/III trials. We evaluate the cost-effectiveness Nirsevimab intervention programmes England Wales. used dynamic model for RSV transmission, calibrated data considered suite potential...
<ns3:p><ns3:bold>Background:</ns3:bold> We aimed to measure SARS-CoV-2 seroprevalence in a cohort of healthcare workers (HCWs) during the first UK wave COVID-19 pandemic, explore risk factors associated with infection, and investigate impact antibody titres on assay sensitivity.</ns3:p><ns3:p> </ns3:p><ns3:p> <ns3:bold>Methods:</ns3:bold> HCWs at Sheffield Teaching Hospitals NHS Foundation Trust were prospectively enrolled sampled two time points. developed an in-house ELISA for testing...