Lorin Adams
A5032427544- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 detection and testing
- Vaccine Coverage and Hesitancy
- Long-Term Effects of COVID-19
- Viral gastroenteritis research and epidemiology
- COVID-19 epidemiological studies
- Animal Virus Infections Studies
- Immunotherapy and Immune Responses
- Bacillus and Francisella bacterial research
- vaccines and immunoinformatics approaches
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Viral Infections and Outbreaks Research
- Influenza Virus Research Studies
- Virus-based gene therapy research
- Respiratory viral infections research
- Vagus Nerve Stimulation Research
- interferon and immune responses
The Francis Crick Institute
2021-2024
The Pirbright Institute
2019
Although mainly causing a respiratory syndrome, numerous neurological symptoms have been identified following of SARS-CoV-2 infection. However, how the virus affects brain and mutations carried by different variants modulate those remain unclear.We used primary human pericytes, foetal astrocytes, endothelial cells microglial cell line to investigate effect several concern or interest on their functional activities. Cells 3D blood-brain barrier model were infected with wild-type form...
The emergence of successive Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) variants concern (VOCs) during 2020 to 2022, each exhibiting increased epidemic growth relative earlier circulating variants, has created a need understand the drivers such growth. However, both pathogen biology and changing host characteristics—such as varying levels immunity—can combine influence replication transmission SARS-CoV-2 within between hosts. Disentangling role variant in individual-level...
Background SARS-CoV-2 variant Omicron rapidly evolved over 2022, causing three waves of infection due to sub-variants BA.1, BA.2 and BA.4/5. We sought characterise symptoms viral loads the course COVID-19 with these in otherwise-healthy, vaccinated, non-hospitalised adults, compared data infections preceding Delta concern (VOC). Methods In a prospective, observational cohort study, healthy vaccinated UK adults who reported positive polymerase chain reaction (PCR) or lateral flow test,...
Abstract Third-dose coronavirus disease 2019 vaccines are being deployed widely but their efficacy has not been assessed adequately in vulnerable older people who exhibit suboptimal responses after primary vaccination series. This observational study, which was carried out by the VIVALDI study based England, looked at spike-specific immune 341 staff and residents long-term care facilities received an mRNA vaccine following dual series with BNT162b2 or ChAdOx1. strongly increased antibody...
Porcine deltacoronavirus (PDCoV) was first identified in Hong Kong 2012 from samples taken pigs 2009. PDCoV subsequently the USA 2014 with a history of severe diarrhea. The virus has now been detected several countries around world. Following development tissue culture adapted strains PDCoV, it is possible to address questions regarding virus–host cell interactions for this genera coronavirus. Here, we presented detailed study PDCoV-induced replication organelles. All positive-strand RNA...
Abstract We describe a Sanger sequencing protocol for SARS‐CoV‐2 S‐gene the Spike (S)‐glycoprotein product of which, composed receptor‐binding (S1) and membrane fusion (S2) segments, is target vaccines used to combat COVID‐19. The can be in laboratories with basic capabilities allows rapid “at source” screening variants, notably those concern. has been applied surveillance, clinical specimens collected either nucleic acid preservation lysis‐mix or virus transport medium, research involving...
Abstract Porcine deltacoronavirus (PDCoV) was first identified in Hong Kong 2012 from samples taken pigs 2009. PDCoV subsequently the USA 2014 with a history of severe diarrhea and virus has now been detected several countries around world. Following development tissue culture adapted strains PDCoV, it is possible to begin address questions regarding virus-host cell interactions for this genera coronavirus. Here we present detailed study induced replication organelles. All positive strand...
Abstract The emergence of successive SARS-CoV-2 variants concern (VOC) during 2020-22, each exhibiting increased epidemic growth relative to earlier circulating variants, has created a need understand the drivers such growth. However, both pathogen biology and changing host characteristics – as varying levels immunity can combine influence replication transmission within between hosts. Disentangling role variant in individual-level viral shedding VOCs is essential inform COVID-19 planning...
Abstract Background SARS-CoV-2 variant Omicron rapidly evolved over 2022, causing three waves of infection due to sub-variants BA.1, BA.2 and BA.4/5. We sought characterise symptoms viral loads the course COVID-19 with these in otherwise-healthy, vaccinated, non-hospitalised adults, compared data infections preceding Delta concern (VOC). Methods In a prospective, observational cohort study, healthy vaccinated UK adults who reported positive PCR or lateral flow test, self-swabbed on alternate...
Abstract Influenza remains a significant threat to human and animal health. Assessing serological protection against influenza has relied upon haemagglutinin inhibition assays, which are used gauge existing immune landscapes, seasonal vaccine decisions in systems vaccinology studies. Here, we adapt our high-throughput live virus microneutralisation assay for SARS-CoV-2, benchmark report responsiveness cohort of older (>65yo) community dwelling adults (n=73), after the adjuvanted 2021-22...