A5024838257- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Ophthalmology and Eye Disorders
- COVID-19 epidemiological studies
- Nasolacrimal Duct Obstruction Treatments
- Cerebral Venous Sinus Thrombosis
- Intraocular Surgery and Lenses
- Vestibular and auditory disorders
- Vaccine Coverage and Hesitancy
- Glaucoma and retinal disorders
- Corneal surgery and disorders
- COVID-19 and Mental Health
- Botulinum Toxin and Related Neurological Disorders
- Pharmacological Effects and Toxicity Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Vasculitis and related conditions
- Ocular Surface and Contact Lens
- Gallbladder and Bile Duct Disorders
- Ocular Diseases and Behçet’s Syndrome
- Systemic Lupus Erythematosus Research
- Hemoglobinopathies and Related Disorders
- Cancer and Skin Lesions
- Congenital Anomalies and Fetal Surgery
- Respiratory viral infections research
- Retinal and Optic Conditions
University of Birmingham
2021-2024
University of the Fraser Valley
2024
Institute of Immunology
2021
National Health Service
2021
Imperial College Healthcare NHS Trust
2021
Imperial College London
2021
National Hospital for Neurology and Neurosurgery
1996-2006
University College London
1996-2006
Western Eye Hospital
1998-2002
Western General Hospital
1998-2002
The BNT162b2 vaccine is highly effective against COVID-19 infection and was delivered with a 3-week time interval in registration studies1. However, many countries extended this to accelerate population coverage single vaccine. It not known how immune responses are influenced by delaying the second dose. We provide assessment of first 14 weeks after standard or extended-interval vaccination show that dose strongly boosts peak antibody response 3.5-fold older people. This enhanced may offer...
Total hip arthroplasty in patients with posttraumatic arthritis has produced results inferior to those nontraumatic arthritis. The use of cementless acetabular reconstruction, however, not been extensively studied this clinical context. Our purpose was compare the intermediate-term total a component same procedure We also compared who had prior operative treatment their fracture closed fracture.Thirty arthroplasties were performed hemispheric, fiber-metal-mesh-coated for osteoarthritis after...
Abstract Third-dose coronavirus disease 2019 vaccines are being deployed widely but their efficacy has not been assessed adequately in vulnerable older people who exhibit suboptimal responses after primary vaccination series. This observational study, which was carried out by the VIVALDI study based England, looked at spike-specific immune 341 staff and residents long-term care facilities received an mRNA vaccine following dual series with BNT162b2 or ChAdOx1. strongly increased antibody...
Age is the major risk factor for mortality after SARS-CoV-2 infection and older people have received priority consideration COVID-19 vaccination. However, vaccine responses are often suboptimal in this age group few over of 80 years were included registration trials. We determined serological cellular response to spike protein 100 aged 80–96 at 2 weeks second vaccination with Pfizer BNT162b2 mRNA vaccine. Antibody seen every donor high titers 98%. Spike-specific immune detectable only 63%...
Omicron variants of SARS-CoV-2 are globally dominant and infection rates very high in children. We measure immune responses following BA.1/2 children aged 6-14 years relate this to prior subsequent or vaccination. Primary elicits a weak antibody response with poor functional neutralizing antibodies. Subsequent reinfection COVID-19 vaccination increased titres broad neutralisation subvariants. Prior pre-Omicron virus primes for robust but these remain primarily focussed against ancestral...
Background: Age is the major risk factor for mortality after SARS-CoV-2 infection and older people have received priority consideration COVID-19 vaccination. However vaccine responses are often suboptimal in this age group few over of 80 years were included registration trials.Methods: We determined serological cellular response to spike protein 100 aged 80-96 at 2 weeks second vaccination with Pfizer BNT162b2 mRNA vaccine.Findings: Antibody seen every donor high titres 98%. Spike-specific...
A 44-year-old man with severe visual loss due to an acute bilateral sequential optic neuropathy is described, where the associated pulmonary disease and peripheral eosinophilia led a diagnosis of Churg-Strauss syndrome (allergic angiitis). The mechanism was most probably ischaemia anterior nerve direct involvement short posterior ciliary arteries by inflammatory vessel wall.
Horizontal and vertical components of spontaneous nystagmus in the dark were assessed 40 healthy subjects with monocular computerised video-oculography. Five different static head-in-space positions used: sitting upright, face up, right ear down, left down; head-on-trunk position being kept same each position. In position, four (10%) had downbeat (slow-phase velocity [SPV] 0.7 °/s, SD 0.27) 12 (30%) upbeat (SPV 2.58 1.38). supine three (7.5%) 5.60 6.72) 25 (62.5%) 3.86 4.54). The direction...
Repeated coronavirus infections in childhood drive progressive maturation of systemic immune responses into adulthood. Analyses children have focused primarily upon assessment but the importance mucosal immunity is increasingly recognised. We studied virus-specific antibody contemporaneous nasal swabs and blood samples from 99 (4-15 years) 28 adults (22-56 years), all whom had prior SARS-CoV-2 infection. Whilst IgA titres against Influenza Respiratory Syncytial virus were comparable between...
The adjustable suture technique in adult strabismus surgery is well established. aim of this study was to assess its feasibilty/outcome a younger age group. A retrospective review 359 case notes patients, under the 16 years, who underwent squint between 1992 and 1999 carried out. Of these, 45 (13%) had undergone with technique. Post-operatively, 34 patients achieved an angle +/- 10 pd required no further treatment. We sought co-operation from parents encouraged their active participation...
General population studies have shown strong humoral response following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination with subsequent waning of anti-spike antibody levels. Vaccine-induced immune responses are often attenuated in frail and older populations, but published data scarce. We measured SARS-CoV-2 levels long-term care facility residents staff a second dose Oxford-AstraZeneca or Pfizer-BioNTech. Vaccination elicited robust residents, suggesting comparable...
Abstract Three patients with episodic ocular torsion and skew deviation due to mesodiencephalic lesions were studied by using binocular three‐dimensional scleral search coils. The conjugate (upper pole of each eye rotating toward the side brainstem lesion) was initiated a torsional fast movement. During prolonged episodes, nystagmus also present. Cessation occurred slow movements exponentially decreasing velocities in 2 patients, multiple 1 patient. In patient, abnormal temporally linked...