A5090061903- Birth, Development, and Health
- Health, Environment, Cognitive Aging
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Pregnancy and preeclampsia studies
- Air Quality and Health Impacts
- Thyroid Disorders and Treatments
- Maternal Mental Health During Pregnancy and Postpartum
- Neonatal Respiratory Health Research
- Breastfeeding Practices and Influences
- Neonatal Health and Biochemistry
- Health disparities and outcomes
- Delphi Technique in Research
- Allergic Rhinitis and Sensitization
- Noise Effects and Management
- Obesity, Physical Activity, Diet
- Asthma and respiratory diseases
- Thyroid Cancer Diagnosis and Treatment
- Nutritional Studies and Diet
- Cytomegalovirus and herpesvirus research
- Effects and risks of endocrine disrupting chemicals
- Climate Change and Health Impacts
- Child and Adolescent Health
- Immune Cell Function and Interaction
- Herpesvirus Infections and Treatments
Bradford Teaching Hospitals NHS Foundation Trust
2014-2025
University of Bradford
2012-2023
Bradford Royal Infirmary
2011-2023
National Health Service
2022-2023
Medical Research Council
2012
Loughborough University
2012
University of Edinburgh
2012
University of York
2012
Bradford Institute for Health Research, Teaching Hospitals Foundation Trust, Bradford, UK, School of Studies, University Edinburgh Ethnicity and Research Group, Centre Population Sciences, College Medicine Veterinary Medicine, Edinburgh, Sport, Exercise Loughborough University, Leicestershire, Medical Council Causal Analyses in Translational Epidemiology, Social Community Bristol, Paediatric Epidemiology Biostatistics, Leeds Genetics, Therapeutics, Faculty Health, Leeds, UK Department York,
Essential to exposome research is the collection of data on many environmental exposures from different domains in same subjects. The aim Human Early Life Exposome (HELIX) study was measure and describe multiple during early life (pregnancy childhood) a prospective cohort associate these with molecular omics signatures child health outcomes. Here, we recruitment, measurements available baseline HELIX populations.The represents collaborative project across six established ongoing longitudinal...
Abstract SARS-CoV-2 infection is generally mild or asymptomatic in children but a biological basis for this outcome unclear. Here we compare antibody and cellular immunity (aged 3–11 years) adults. Antibody responses against spike protein were high seroconversion boosted seasonal Beta-coronaviruses through cross-recognition of the S2 domain. Neutralization viral variants was comparable between Spike-specific T cell more than twice as also detected many seronegative children, indicating...
Exposome studies are challenged by exposure misclassification for non-persistent chemicals, whose temporal variability contributes to bias in dose-response functions.We evaluated the of urinary concentrations 24 chemicals: 10 phthalate metabolites, 7 phenols, 6 organophosphate (OP) pesticide and cotinine, between weeks from different pregnancy trimesters pregnant women, days seasons children.154 women 152 children six European countries were enrolled 2014-2015. Pregnant provided three urine...
Characterization of the "exposome", set all environmental factors that one is exposed to from conception onwards, has been advocated better understand role on chronic diseases. Here, we aimed describe early-life exposome. Specifically, focused correlations between multiple exposures, their patterns and variability across European regions time (pregnancy childhood periods). We relied Human Early-Life Exposome (HELIX) project, in which 87 exposures during pregnancy 122 period (grouped 19...
Early interventions are recognised as key to improving life chances for children and reducing inequalities in health well-being, however there is a paucity of high quality research into the effectiveness address childhood development outcomes. Planning implementing standalone RCTs multiple, individual would be slow, cumbersome expensive. This paper describes protocol an innovative experimental birth cohort: Born Bradford's Better Start (BiBBS) that will simultaneously evaluate impact...
Abstract Background Understanding differences in sensitization profiles at the molecular allergen level is important for diagnosis, personalized treatment and prevention strategies allergy. Methods Immunoglobulin E (IgE) were determined more than 2800 sera from children nine population‐based cohorts different geographical regions of Europe; north [BAMSE (Sweden), ECA (Norway)], west/central [PIAMA (the Netherlands), BiB United Kingdom), GINIplus (Germany)], south [INMA Sabadell Gipuzkoa...
Key Features� Born in Bradford (BiB) is a multi-ethnic birth cohort Bradford, UK, which recruited 12 453 women with 13 776 pregnancies and 3448 of their partners between 2007 2011.� Routine health education data have been collected since subsamples followed up to age 5 years.Metabolomics genetic are available for �11 000 mothers �9000 children.The works closely communities providers using findings influence policy.� This update summarizes the most recent follow-up school community settings...
Background. Despite reported differences in breastfeeding rates amongst women of different ethnic groups, little research has investigated whether the thoughts and feelings (social cognitions) from these groups during pregnancy influence their later behaviour. Objective. This study investigates extent to which social cognitions (based on Theory Planned Behaviour; TPB) predict intentions, initiation, maintenance between White British (WB) South Asian (SA) women. Design methods. Two hundred...
Born in Bradford (BiB) is a prospective multi-ethnic pregnancy and birth cohort study that was established to examine determinants of health development during childhood and, subsequently, adult life deprived population the north England. Between 2007 2010, BiB recruited 12,453 women who experienced 13,776 pregnancies 13,858 births, along with 3353 their partners. Forty five percent are Pakistani origin. Now children at primary school, first full follow-up taking place. The aims investigate...
Omicron variants of SARS-CoV-2 are globally dominant and infection rates very high in children. We measure immune responses following BA.1/2 children aged 6-14 years relate this to prior subsequent or vaccination. Primary elicits a weak antibody response with poor functional neutralizing antibodies. Subsequent reinfection COVID-19 vaccination increased titres broad neutralisation subvariants. Prior pre-Omicron virus primes for robust but these remain primarily focussed against ancestral...
This paper provides an overview of the INGENIOUS (UnderstandING sourcEs, traNsformations and fates IndOor air pollUtantS) project, aiming to better understand pollution in homes. Although our homes are microenvironment which we spend most time, know relatively little about sources, transformation processes indoor pollutants, or exposure them. aims address this knowledge gap by delivering: emissions inventory for UK homes; comprehensive pollutant measurements 310 Bradford using a combination...
Summary West J, Manchester B, Wright Lawlor DA, Waiblinger D. Reliability of routine clinical measurements neonatal circumferences and research skinfold thicknesses: findings from the Born in Bradford study. Paediatric Perinatal Epidemiology 2011. Assessing size reliably is important for practice. The aim this study was to examine reliability thicknesses assessed purposes. All were undertaken on same population neonates born a large maternity unit Bradford, UK. Technical error measurement...
<b><i>Background:</i></b> Numerous birth cohorts have been initiated in the world over past 30 years using heterogeneous methods to assess incidence, course and risk factors of asthma allergies. The aim present work is provide stepwise proceedings development current version harmonized MeDALL-Core Questionnaire (MeDALL-CQ) used prospectively 11 European cohorts. <b><i>Methods:</i></b> harmonization questions was accomplished 4 steps: (i)...
<ns4:p><ns4:bold>Background:</ns4:bold> The Born in Bradford’s Better Start (BiBBS) interventional birth cohort study was designed as an innovative platform for efficient evaluation of early life interventions delivered through the Bradford programme. There are a growing number cohorts being implemented internationally. This paper provides interim analysis BiBBS order to share learning about feasibility and value this method.</ns4:p><ns4:p> <ns4:bold>Methods:</ns4:bold> Recruitment began...
Using a multi-methods approach we aimed to explore the relative prediction of demographic, socioeconomic and modifiable predictors from Theory Planned behaviour (TPB) in explaining feeding intentions amongst multi-ethnic sample. 476 women completed questionnaire at 28 weeks gestation. They were grouped into breastfeeding (N = 258), mixed-feeding 50), bottle-feeding 88) intenders, or no clear intention 88). Multinomial adjusted regressions explored influence TPB factors, along with ethnicity...
<ns4:p><ns4:bold>Background:</ns4:bold> The Born in Bradford’s Better Start (BiBBS) interventional birth cohort study was designed as an innovative platform for efficient evaluation of early life interventions delivered through the Bradford programme. There are a growing number cohorts being implemented internationally. This paper provides interim analysis BiBBS order to share learning about feasibility and value this method.</ns4:p><ns4:p> <ns4:bold>Methods:</ns4:bold> Recruitment began...
Cytomegalovirus (CMV), Epstein Barr virus (EBV) and varicella-zoster (VZV) are common herpesviruses frequently acquired in childhood, which establish persistent, latent infection likely to impact the developing immune system. Little is known about epidemiology of CMV EBV infections contemporary UK paediatric populations, particularly whether age at differs by ethnic group. Children enrolled Born Bradford Allergy Infection Study had a blood sample taken questionnaire completed 12 24 months...
Severe iodine insufficiency in pregnancy has significant consequences, but there is inadequate evidence to indicate what constitutes mild or moderate insufficiency, terms of observed detrimental effects on birth outcomes. A limited number studies have examined status and outcomes, finding inconsistent for specific outcomes.Maternal was estimated from spot urine samples collected at 26-28 weeks' gestation 6971 mothers the Born Bradford cohort. Associations with outcomes were both urinary...
Initiation of breast feeding and duration any are known to differ by ethnic group, but there limited data on differences in exclusive feeding. This study aimed determine if the initiation feeding.Breast-feeding were obtained from a subsample 1365 women recruited multi-ethnic cohort (Born Bradford) between August 2008 March 2009. Poisson regression was used investigate impact socio-economic, life style birth factors prevalence feeding.Compared with white British mothers, significantly higher...
Abstract Background Maternal iodine requirements increase during pregnancy to supply thyroid hormones critical for fetal neurodevelopment. Iodine insufficiency may result in poorer cognitive or child educational outcomes but current evidence is sparse and inconsistent. Objectives To quantify the association between maternal status outcomes. Methods Urinary concentrations (UIC) iodine/creatinine ratios (I:Cr) were measured 6971 mothers at 26‐28 weeks' gestation participating Born Bradford...
Iodine is essential for normal thyroid function, supporting healthy fetal and child development. requirements increase in pregnancy, but many women regions without salt iodization have insufficient intakes. We explored associations between iodide intake urinary iodine concentration (UIC), iodine/creatinine ratio (I/Cr), stimulating hormone, thyroglobulin, free triiodothyronine, thyroxine palpable goiter a region of mild-to-moderate insufficiency. A total 246 pregnant aged 18–40 Bradford, UK,...