A5073842398- Allergic Rhinitis and Sensitization
- Food Allergy and Anaphylaxis Research
- Asthma and respiratory diseases
- Contact Dermatitis and Allergies
- Monoclonal and Polyclonal Antibodies Research
- Glycosylation and Glycoproteins Research
- Occupational exposure and asthma
- IgG4-Related and Inflammatory Diseases
- Blood groups and transfusion
- Immunodeficiency and Autoimmune Disorders
- Protein purification and stability
- Dermatology and Skin Diseases
- Neuroendocrine Tumor Research Advances
- T-cell and B-cell Immunology
- Mast cells and histamine
- Platelet Disorders and Treatments
- Insect and Pesticide Research
- Gastrointestinal disorders and treatments
- Indoor Air Quality and Microbial Exposure
- Pediatric health and respiratory diseases
- Respiratory and Cough-Related Research
- Eosinophilic Esophagitis
- Transgenic Plants and Applications
- Drug-Induced Adverse Reactions
- Urticaria and Related Conditions
University of Amsterdam
2012-2023
Sanquin
2014-2023
University of Leicester
2022-2023
Elliot Hospital
2022-2023
Délégation Paris 6
2022-2023
Amsterdam UMC Location University of Amsterdam
2004-2020
Amsterdam University Medical Centers
2018
Dialyse Centrum Groningen
2016
University Medical Center Groningen
2013
University of Groningen
2013
Antibodies play a central role in immunity by forming an interface with the innate immune system and, typically, mediate proinflammatory activity. We describe novel posttranslational modification that leads to anti-inflammatory activity of antibodies immunoglobulin G, isotype 4 (IgG4). IgG4 are dynamic molecules exchange Fab arms swapping heavy chain and attached light (half-molecule) heavy-light pair from another molecule, which results bispecific antibodies. Mutagenesis studies revealed...
The availability of allergen molecules ('components') from several protein families has advanced our understanding immunoglobulin E (IgE)-mediated responses and enabled 'component-resolved diagnosis' (CRD). European Academy Allergy Clinical Immunology (EAACI) Molecular Allergology User's Guide (MAUG) provides comprehensive information on important allergens describes the diagnostic options using CRD. Part A EAACI MAUG introduces molecules, families, composition extracts, databases, IgE,...
John H. Stone, Arezou Khosroshahi, Vikram Deshpande, K. C. Chan, J. Godfrey Heathcote, Rob Aalberse, Atsushi Azumi, Donald B. Bloch, William R. Brugge, Mollie N. Carruthers, Wah Cheuk, Lynn Cornell, Carlos Fernandez-Del Castillo, Judith A. Ferry, David Forcione, Gunter Kloppel, Daniel L. Hamilos, Terumi Kamisawa, Satomi Kasashima, Shigeyuki Kawa, Mitsuhiro Kawano, Yasufumi Masaki, Kenji Notohara, Kazuichi Okazaki, Ji Kon Ryu, Takako Saeki, Dushyant Sahani, Yasuharu Sato, Thomas Smyrk, James...
Abstract Since the discovery of immunoglobulin E (IgE) as a mediator allergic diseases in 1967, our knowledge about immunological mechanisms IgE‐mediated allergies has remarkably increased. In addition to understanding immune response and clinical symptoms, allergy diagnosis management depend strongly on precise identification elicitors reaction. past four decades, innovations bioscience technology have facilitated production well‐defined, highly pure molecules for component‐resolved (CRD),...
<i>Background:</i> Lipid transfer proteins (LTPs) are small molecules of approximately 10 kD that demonstrate high stability. They have recently been identified as allergens in the Rosaceae subfamilies Prunoideae (peach, apricot, plum) and Pomoideae (apple). belong to a family structurally highly conserved also present non-Rosaceae vegetable foods. <i>Objective:</i> The aim this study was investigate cross-reactivity LTPs, role protein stability allergenicity....
The Prevention and Incidence of Asthma Mite Allergy (PIAMA) birth cohort study was initiated in 1996. Children born to allergic mothers were enrolled a double‐blind placebo‐controlled trial for evaluating the use mite‐impermeable mattress pillow covers. non‐allergic ‘natural history’ assess role environmental dietary risk factors development disease childhood. Recruitment started by distributing validated screening questionnaire among >10,000 pregnant women during their first visit...
Sera of 17 patients receiving immunotherapy for house-dust mite allergy were tested IgE antibodies against snail and shrimp. Serum samples taken at the start 14-20 months later. While average response to mite, Der p 1, 2 did not alter significantly, showed a significant increase. This included two conversions from negative strongly positive. These novel shown be cross-reactive with mite. Three had positive RAST For one them, strong increase shrimp (and snail) was observed. In 2/3...
<h3>Background:</h3> Caesarean section might be a risk factor for asthma because of delayed microbial colonisation, but the association remains controversial. A study was undertaken to investigate prospectively whether children born by caesarean are more at having in childhood and sensitisation age 8 years, taking into account allergic status parents. <h3>Methods:</h3> 2917 who participated birth cohort were followed years. The definition included wheeze, dyspnoea prescription inhaled...
A monoclonal antibody to Dermatophagoides pteronyssinus is described that cross-reacts with an IgE-binding antigen present in insects, Crustacea (e.g. shrimp) and other invertebrates. By means of sodium dodecyl sulfate-polyacrylamide gel electrophoresis, filtration immunofluorescence it was shown this presumably recognizes tropomyosin. Tropomyosin be involved cross-reactivity between mite, shrimp insects shrimp-allergic patients.
Immunoglobulin G (IgG) antibodies are symmetrical molecules that may be regarded as covalent dimers of 2 half-molecules, each consisting a light chain and heavy chain. Human IgG4 is an unusually dynamic antibody, with half-molecule exchange ("Fab-arm exchange") resulting in asymmetrical, bispecific two different antigen binding sites, which contributes to its anti-inflammatory activity. The mechanism this process unknown. To elucidate the elementary steps intermolecular antibody...
The Prevention and Incidence of Asthma Mite Allergy (PIAMA) birth cohort was set up in Netherlands with two main aims: to investigate the effect mite-allergen avoidance on incidence childhood asthma (Intervention study) assess lifestyle environmental risk factors for (Natural History study). baseline study population consisted 3963 children born 1996– 1997. Questionnaires were completed by parents during pregnancy, when child 3 months old, then annually from 1 8 years as well at 11 14 years....