A5080056003- Health, Environment, Cognitive Aging
- Birth, Development, and Health
- Air Quality and Health Impacts
- Nutritional Studies and Diet
- Infant Development and Preterm Care
- Maternal Mental Health During Pregnancy and Postpartum
- Attention Deficit Hyperactivity Disorder
- Obesity, Physical Activity, Diet
- Heavy Metal Exposure and Toxicity
- Mercury impact and mitigation studies
- Breastfeeding Practices and Influences
- Child and Adolescent Psychosocial and Emotional Development
- Noise Effects and Management
- Urban Green Space and Health
- Fatty Acid Research and Health
- Early Childhood Education and Development
- Effects and risks of endocrine disrupting chemicals
- Thyroid Disorders and Treatments
- Climate Change and Health Impacts
- Child Nutrition and Water Access
- Epigenetics and DNA Methylation
- Chemical Analysis and Environmental Impact
- Child Nutrition and Feeding Issues
- Pregnancy and preeclampsia studies
- Folate and B Vitamins Research
Instituto de Salud Carlos III
2019-2025
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
2016-2025
Barcelona Institute for Global Health
2016-2025
Institut d'Investigació Sanitària Pere Virgili
2018-2025
Universitat Pompeu Fabra
2015-2025
Barcelona Biomedical Research Park
2009-2024
Universitat Rovira i Virgili
2019-2024
Harvard University
2010-2024
Hospital Universitari Sant Joan de Reus
2018-2024
Fundació Privada Clínic per a La Recerca Biomèdica
2024
Background: Green spaces have been associated with improved mental health in children; however, available epidemiological evidence on their impact child behavioral development is scarce.Objectives: We investigated the of contact green and blue (beaches) indicators symptoms attention deficit/hyperactivity disorder (ADHD) schoolchildren.Methods: This study was based a sample 2,111 schoolchildren (7–10 years age) from 36 schools Barcelona 2012. obtained data time spent beaches Strengths...
Background: Developmental periods in early life may be particularly vulnerable to impacts of environmental exposures. Human research on this topic has generally focused single exposure–health effect relationships. The "exposome" concept encompasses the totality exposures from conception onward, complementing genome.Objectives: Early-Life Exposome (HELIX) project is a new collaborative that aims implement novel exposure assessment and biomarker methods characterize early-life multiple factors...
Essential to exposome research is the collection of data on many environmental exposures from different domains in same subjects. The aim Human Early Life Exposome (HELIX) study was measure and describe multiple during early life (pregnancy childhood) a prospective cohort associate these with molecular omics signatures child health outcomes. Here, we recruitment, measurements available baseline HELIX populations.The represents collaborative project across six established ongoing longitudinal...
Active maternal smoking during pregnancy has been associated with a higher risk of behavioural disorders in children, but few cohort studies measuring data prospectively have studied its specific effects on the cognitive abilities pre-schoolers.A birth was set up Menorca Island 1997 within Asthma Multicenter Infants Cohort Study. A total 420 (87% those eligible) children had complete for final analyses at age 4 years. Interviewer-administered questionnaires were completed by mothers third...
p,p′-DDT (bis[p-chlorophenyl]-1,1,1-trichloroethane) is a persistent organochlorine compound that has been used worldwide as an insecticide. The authors evaluated the association of cord serum levels DDT and its metabolite, 2,2-bis(p-chlorophenyl)-1,1-dichloroethylene (DDE), with neurodevelopment at age 4 years. Two birth cohorts in Ribera d'Ebre Menorca (Spain) were recruited between 1997 1999 (n = 475). Infants assessed years by using McCarthy Scales Children's Abilities. Organochlorine...
<h3>Background</h3> Air pollution from traffic has been associated with cardiorespiratory diseases in children and adults, but there is little information on its potential neurotoxic effects. This study aimed to investigate the association between exposure nitrogen dioxide (NO<sub>2</sub>), as a marker of traffic-related air pollution, cognitive development children. <h3>Methods</h3> A population-based birth cohort southern Spain was followed age 4 years for 1 year. Complete data analyses...
Acetaminophen is extensively used during pregnancy. But there a lack of population-representative cohort studies evaluating its effects on range neuropsychological and behavioural endpoints. We aimed to assess whether prenatal exposure acetaminophen adversely associated with neurodevelopmental outcomes at 1 5 years age.This Spanish birth study included 2644 mother-child pairs recruited The proportion liveborn participants evaluated was 88.8% 79.9%, respectively. Use prospectively in two...
Growing evidence suggests that close contact with nature brings benefits to human health and well-being, but the proposed mechanisms are still not well understood associations remain uncertain. The Positive Health Effects of Natural Outdoor environment in Typical Populations different regions Europe (PHENOTYPE) project investigates interconnections between natural outdoor environments better well-being.The PHENOTYPE explores underlying at work (stress reduction/restorative function, physical...
The fetus depends on maternal thyroid hormones during pregnancy for normal brain development. Little is known about the effects of subclinical hypothyroidism and mild hypothyroxinemia neurodevelopment child.We evaluated a population-based birth cohort in Spain. A total 1761 children their mothers were included main analyses. Serum levels free thyroxine thyrotropin measured pregnant women. Mental psychomotor development was assessed using Bayley Scales Infant Development second year life.Low...
The use of folic acid supplements during very early pregnancy is recommended in order to reduce the incidence neural tube defects. Little known about possible benefits on child neurodevelopment. A total 420 children (87% those eligible) from a birth cohort had complete data for final analyses at age 4 years. Information and other over-the-counter dietary was obtained prospectively using interviewer-administered questionnaires end first trimester pregnancy. Psychological outcomes were...
Introduction Breastfeeding effects on cognition are attributed to long-chain polyunsaturated fatty acids (LC-PUFAs), but controversy persists. Genetic variation in acid desaturase (FADS) and elongase (ELOVL) enzymes has been overlooked when studying the of LC-PUFAs supply cognition. We aimed to: 1) determine whether maternal genetic variants FADS cluster ELOVL genes contribute differences LC-PUFA levels colostrum; 2) analyze these related child cognition; 3) assess children's modify...
Early life is an important window of opportunity to improve health across the full lifecycle. An accumulating body evidence suggests that exposure adverse stressors during early leads developmental adaptations, which subsequently affect disease risk in later life. Also, geographical, socio-economic, and ethnic differences are related inequalities from onwards. To address these public challenges, many European pregnancy childhood cohorts have been established over last 30 years. The enormous...
Seafood consumption during pregnancy is thought to be beneficial for child neuropsychological development, but our knowledge no large cohort studies with high fatty fish have analyzed the association by seafood subtype. We evaluated 1,892 and 1,589 mother-child pairs at ages of 14 months 5 years, respectively, in a population-based Spanish birth established 2004–2008. Bayley McCarthy scales Childhood Asperger Syndrome Test were used assess development. Results from multivariate linear...
IMPORTANCE Folate intake during pregnancy has been associated with improved neuropsychological development in children, although the effects of high dosages folic acid (FA) supplements are unclear.OBJECTIVE To examine association between use FA and child after first year life. DESIGN, SETTING, AND PATIENTSThe multicenter prospective mother-child cohort Infancia y Medio Ambiente (INMA) Project recruited pregnant women from 4 areas Spain (Asturias, Sabadell, Gipuzkoa, Valencia) November 2003...
Background: Vitamin D status during prenatal brain development may influence risk of attention deficit and hyperactivity disorder (ADHD) symptoms in childhood. However, there are no prospective studies addressing this hypothesis. We aimed to examine whether maternal vitamin pregnancy is associated with ADHD-like offspring. Methods: conducted a study analyzing data from 1,650 mother–child pairs five birth cohorts embedded the INMA Project (Spain, 1997–2008). Maternal was estimated by...
Environmental exposures in early life influence the development of behavioral outcomes children, but research has not considered multiple exposures. We therefore aimed to investigate impact a broad spectrum pre- and postnatal environmental on child behavior. used data from HELIX (Human Early Life Exposome) project, which was based six longitudinal population-based birth cohorts Europe. At 6–11 years, children underwent follow-up characterize their assess problems. measured 88 prenatal 123...
Epidemiological studies mostly focus on single environmental exposures. This study aims to systematically assess associations between a wide range of prenatal and childhood exposures cognition. The sample included data 1298 mother-child pairs, children were 6-11 years-old, from six European birth cohorts. We measured 87 during pregnancy 122 cross-sectionally childhood, including air pollution, built environment, meteorology, natural spaces, traffic, noise, chemicals life styles. cognitive...
Abstract Background Early life environmental stressors play an important role in the development of multiple chronic disorders. Previous studies that used risk scores (ERS) to assess cumulative impact exposures on health are limited by diversity included, especially for early determinants. We machine learning methods build exposome three outcomes using environmental, molecular, and clinical data. Methods In this study, we analyzed data from 1622 mother-child pairs HELIX European birth...
BackgroundThe long-term neurotoxicity risks caused by prenatal exposures to pesticides are unclear, but a previous pilot study of Ecuadorian school children suggested that blood pressure and visuospatial processing may be vulnerable.ObjectivesIn northern Ecuador, where floriculture is intensive relies on female employment, we carried out an cross-sectional assess children's neurobehavioral functions at 6–8 years age.MethodsWe examined all 87 attending two grades in the local public with...