A5027962960- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Tryptophan and brain disorders
- Resilience and Mental Health
- Privacy-Preserving Technologies in Data
- COVID-19 and Mental Health
- Receptor Mechanisms and Signaling
- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Adipose Tissue and Metabolism
- Artificial Intelligence in Healthcare and Education
- Hormonal Regulation and Hypertension
- Neurotransmitter Receptor Influence on Behavior
- Psychological Well-being and Life Satisfaction
- Estrogen and related hormone effects
- Hypothalamic control of reproductive hormones
- Optimism, Hope, and Well-being
- Pharmacological Effects of Natural Compounds
- Neuropeptides and Animal Physiology
- Genetics and Neurodevelopmental Disorders
- Nuclear Receptors and Signaling
- Menopause: Health Impacts and Treatments
- Health disparities and outcomes
- Cryptography and Data Security
- Macrophage Migration Inhibitory Factor
Concentris (Germany)
2022-2023
Herzliya Medical Center
2022
Humboldt-Universität zu Berlin
2022
Technische Universität Dresden
2022
Charité - Universitätsmedizin Berlin
2022
Freie Universität Berlin
2022
Wacker (United States)
2022
Leibniz Institute for Resilience Research
2022
Hospital Del Mar
2020
Barcelona Biomedical Research Park
2020
The prevalence of inflammatory diseases is increasing in modern urban societies. Inflammation increases risk stress-related pathology; consequently, immunoregulatory or antiinflammatory approaches may protect against negative outcomes. We show that stress disrupts the homeostatic relationship between microbiota and host, resulting exaggerated inflammation. Repeated immunization with a heat-killed preparation Mycobacterium vaccae, an environmental microorganism, reduced subordinate, flight,...
Early life is an important window of opportunity to improve health across the full lifecycle. An accumulating body evidence suggests that exposure adverse stressors during early leads developmental adaptations, which subsequently affect disease risk in later life. Also, geographical, socio-economic, and ethnic differences are related inequalities from onwards. To address these public challenges, many European pregnancy childhood cohorts have been established over last 30 years. The enormous...
Abstract Prolactin (PRL) has been shown to promote maternal behaviour, and regulate neuroendocrine emotional stress responses. These effects appear more important in the peripartum period, when brain PRL system is highly activated. Here, we studied mechanisms that underlie anti‐stress of PRL. Ovariectomized, estradiol‐substituted Wistar rats were implanted with an intracerebroventricular cannula treated ovine (0.01, 0.1 or 1 µg/h; 5 days via osmotic minipumps) vehicle, their responses acute...
Background Machine learning and artificial intelligence have shown promising results in many areas are driven by the increasing amount of available data. However, these data often distributed across different institutions cannot be easily shared owing to strict privacy regulations. Federated (FL) allows training machine models without sharing sensitive In addition, implementation is time-consuming requires advanced programming skills complex technical infrastructures. Objective Various tools...
Background Cross-sectional relationships between psychosocial resilience factors (RFs) and resilience, operationalized as the outcome of low mental health reactivity to stressor exposure (low “stressor reactivity” [SR]), were reported during first wave COVID-19 pandemic in 2020. Objective Extending these findings, we here examined prospective weekly dynamics same RFs SR a longitudinal sample aftermath several European countries. Methods Over 5 weeks app-based assessments, participants...
Background Allelic variations in TPH2, the gene encoding tryptophan hydroxylase 2, rate-limiting enzyme for brain serotonin (5-HT) biosynthesis, may be genetic predictors of panic disorder and responses to panicogenic challenges healthy volunteers. To test hypothesis that tph2 mRNA is altered chronic anxiety states, we measured expression an established rat model disorder. Methods We implanted 16 adult, male rats with bilateral guide cannulae then primed them daily injections...
Abstract Multiple lines of evidence implicate brain serotonin (5-hydroxytryptamine; 5-HT) system dysfunction in the pathophysiology stressor-related and anxiety disorders. Here we investigate influence constitutively deficient 5-HT synthesis on anxiety-like behaviors using Tryptophan hydroxylase 2 ( Tph2 ) mutant mice. Functional assessment c-Fos after associated foot shock, electrophysiological recordings GABAergic synaptic transmission, differential expression Slc6a4 gene serotonergic...
Expression of TPH2, the rate-limiting enzyme for brain serotonin synthesis, is elevated in dorsal raphe nucleus (DR) depressed suicide victims. One hypothesis that this increase TPH2 expression stress-induced. Here, we used an established animal model to address whether exposure acute stressor, inescapable tail shock (IS), increases tph2 mRNA and Tph2 protein expression, if IS sensitizes DR a subsequent, heterotypic stressor. In Experiment 1, measured 4 h after or home cage (HC) control...
Chronic intracerebroventricular (icv) infusion of prolactin (PRL) into the cerebral ventricles and mimicking central hyperprolactinemia in lactation has recently been shown to reduce anxiety neuronal as well neuroendocrine responses acute stressor exposure. Here, we studied effects icv PRL on activity oxytocin (OXT) arginine vasopressin (AVP) systems virgin female, ovariectomized, estradiol-substituted Wistar rats. Ovine was delivered via osmotic minipumps at 0.01, 0.1 or 1 microg/h for 5...
Previous studies suggest that multiple corticolimbic and hypothalamic structures are involved in glucocorticoid-mediated feedback inhibition of the hypothalamic–pituitary–adrenal (HPA) axis, including dorsomedial hypothalamus (DMH), but a potential role DMH has not been directly tested. To investigate negative feedback, adult male Sprague Dawley rats were implanted with jugular cannulae bilateral guide directed at DMH, finally either adrenalectomized (ADX) or subjected to sham-ADX. ADX...
Machine Learning (ML) and Artificial Intelligence (AI) have shown promising results in many areas are driven by the increasing amount of available data. However, this data is often distributed across different institutions cannot be shared due to privacy concerns. Privacy-preserving methods, such as Federated (FL), allow for training ML models without sharing sensitive data, but their implementation time-consuming requires advanced programming skills. Here, we present FeatureCloud AI Store...
Recently, cross-sectional relationships between psycho-social resilience factors (RFs) and resilience, operationalized as an outcome of low reactivity mental health to stressor exposure (low ‘stressor reactivity’) during the first wave COVID-19 pandemic, were reported. Extending these findings, we here examine prospective weekly dynamics same RFs in a longitudinal sample aftermath several European countries. Over five weeks app-based assessments, participants reported exposure, problems,...
Abstract Recently, cross-sectional relationships between psycho-social resilience factors (RFs) and resilience, operationalized as an outcome of low reactivity mental health to stressor exposure (low ‘stressor reactivity’) during the first wave COVID-19 pandemic, were reported. Extending these findings, we here examine prospective weekly dynamics same RFs in a longitudinal sample aftermath several European countries. Over five weeks app-based assessments, participants reported exposure,...