A5010436123- Diabetes Treatment and Management
- Chronic Kidney Disease and Diabetes
- Diabetes Management and Research
- COVID-19 Clinical Research Studies
- Diabetes and associated disorders
- Blood Pressure and Hypertension Studies
- Peripheral Artery Disease Management
- Dialysis and Renal Disease Management
- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Diabetic Foot Ulcer Assessment and Management
- Liver Disease Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Nutritional Studies and Diet
- Diet and metabolism studies
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Advanced Glycation End Products research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- COVID-19 and healthcare impacts
- Pharmacology and Obesity Treatment
- Neuropeptides and Animal Physiology
- Retinal Diseases and Treatments
- Pancreatic function and diabetes
- Cardiac Imaging and Diagnostics
- Lipoproteins and Cardiovascular Health
Centre Hospitalier Universitaire de Poitiers
2016-2025
Université de Poitiers
2016-2025
Inserm
2016-2025
National Institute of Diabetes and Digestive and Kidney Diseases
2016-2023
National Institutes of Health
2016-2023
Centre Hospitalier Universitaire d'Angers
2023
Phoenix (United States)
2016-2021
Arizona Research Center
2016-2017
Assistance Publique – Hôpitaux de Paris
2015-2016
Hôpital Bichat-Claude-Bernard
2016
Coronavirus disease-2019 (COVID-19) is a life-threatening infection caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus. Diabetes has rapidly emerged as major comorbidity for COVID-19 severity. However, phenotypic characteristics of diabetes in patients are unknown. We conducted nationwide multicentre observational study people with hospitalised 53 French centres period 10–31 March 2020. The primary outcome combined tracheal intubation mechanical ventilation...
Essential to exposome research is the collection of data on many environmental exposures from different domains in same subjects. The aim Human Early Life Exposome (HELIX) study was measure and describe multiple during early life (pregnancy childhood) a prospective cohort associate these with molecular omics signatures child health outcomes. Here, we recruitment, measurements available baseline HELIX populations.The represents collaborative project across six established ongoing longitudinal...
Harmonized data describing simultaneous exposure to a large number of environmental contaminants in-utero and during childhood is currently very limited.To characterize concentrations in pregnant women from Europe their children, based on chemical analysis biological samples mother-child pairs.We relied the Early-Life Exposome project, HELIX, collaborative project across six established population-based birth cohort studies Europe. In 1301 subjects, biomarkers 45 (i.e. organochlorine...
Background The role and performance of chest CT in the diagnosis coronavirus disease 2019 (COVID-19) pandemic remains under active investigation. Purpose To evaluate French national experience using for COVID-19, results reverse transcription polymerase chain reaction (RT-PCR) assays were compared together with final discharge used as reference standard. Materials Methods A structured scan survey (NCT04339686) was sent to 26 hospital radiology departments France between March 2, 2020, April...
Abstract Aim To assess the relationship between body mass index (BMI) classes and early COVID‐19 prognosis in inpatients with type 2 diabetes (T2D). Methods From CORONAvirus‐SARS‐CoV‐2 Diabetes Outcomes (CORONADO) study, we conducted an analysis patients T2D categorized by four BMI subgroups according to World Health Organization classification. Clinical characteristics COVID‐19–related outcomes (i.e. intubation for mechanical ventilation [IMV], death discharge day 7 [D7]) were analysed...
Abstract Aims Several reports have suggested a relationship between male sex and albuminuria in Type 2 diabetes, but impact on renal function decline has not been established. Our aim was to describe the influence of diabetes. Methods SURDIAGENE, an inception cohort, consisted 1470 people with Patients without replacement therapy ≥ 3 serum creatinine determinations during follow‐up prior end‐stage disease were included study. Estimated glomerular filtration rate calculated using Chronic...
We examined associations of advanced glycation end products (AGEs) with renal function loss (RFL) and its structural determinants in American Indians type 2 diabetes. Data were from a 6-year clinical trial that assessed renoprotective efficacy losartan. Participants remained under observation after the concluded. Glomerular filtration rate (GFR) was measured annually. Kidney biopsies performed at trial. Five AGEs serum collected enrollment kidney biopsy. RFL defined as ≥40% decline GFR...
Renal dysfunction is a key risk factor for all-cause mortality in patients with type 2 diabetes (T2D). Circulating tumor necrosis receptor 1 (TNFR1) was recently suggested as strong biomarker end-stage renal failure T2D. However, its relevance regarding death has yet to be conclusively established. We aimed assess the prognostic value of serum TNFR1 concentration T2D and diabetic kidney disease (DKD) from SURDIAGENE (Survie, Diabete de et Genetique) study.A total 522 DKD (estimated...
Significance Statement Although diabetic nephropathy is assessed clinically by measuring eGFR and albuminuria, structural kidney damage typically precedes these clinical manifestations. Previous studies have early change in type 1 diabetes but not 2. In a study of American Indian patients with 2 generally preserved function, the authors found changes structure over an average 9 years, as determined quantitative morphometric analysis biopsy specimens. They also that were more consistently...
This study applies a large proteomics panel to search for new circulating biomarkers associated with progression kidney failure in individuals diabetic disease. Four independent cohorts encompassing 754 type 1 and 2 diabetes early late disease were followed ascertain failure. During ten years of follow-up, 227 progressed Using the SOMAscan platform, we measured baseline concentration 1129 proteins. In our previous publications, analyzed 334 these proteins that members specific candidate...
Circulating proteins associated with transforming growth factor-β (TGF-β) signaling are implicated in the development of diabetic kidney disease (DKD). It remains to be comprehensively examined which these involved pathogenesis DKD and its progression end-stage (ESKD) humans. Using SOMAscan proteomic platform, we measured concentrations 25 TGF-β family four different cohorts composed total 754 Caucasian or Pima Indian individuals type 1 2 diabetes. Of circulating proteins, identified...
After more than 50 years of treating Parkinson's disease with l-DOPA, there are still no guidelines on setting the optimal dose for a given patient. The dopamine transporter type 1, now known as solute carrier family 6 (neurotransmitter transporter), member 3 (SLC6A3) is most powerful determinant neurotransmission and might therefore influence treatment response. We recently demonstrated that methylphenidate (a inhibitor) effective in patients motor gait disorders. objective present study...
OBJECTIVE Subjects with diabetes are prone to the development of cardiovascular and noncardiovascular complications. In separate studies, acute kidney injury (AKI), albuminuria, low estimated glomerular filtration rate (eGFR) were shown predict adverse outcomes, but, when considered together, their respective prognostic value is unknown. RESEARCH DESIGN AND METHODS Patients type 2 consecutively recruited in SURDIAGENE cohort prospectively followed up for major diabetes-related events, as...
We explored the prognostic value of three circulating candidate biomarkers-midregional-proadrenomedullin (MR-proADM), soluble tumor necrosis factor receptor 1 (sTNFR1), and N-terminal prohormone brain natriuretic peptide (NT-proBNP)-for change in renal function patients with type 2 diabetes.Outcomes were defined as loss (RFL), ≥40% decline estimated glomerular filtration rate (eGFR) from baseline, rapid (RRFD), absolute annual eGFR slope <-5 mL/min/year. used a proportional hazard model for...
Cardiovascular disease and kidney damage are tightly associated in people with type 2 diabetes. Experimental evidence supports a causal role for vasopressin (or antidiuretic hormone) the development of diabetic (DKD). Plasma copeptin, COOH-terminal portion pre-provasopressin surrogate marker vasopressin, was shown to be positively progression DKD. Here we assessed association plasma copeptin risk cardiovascular events during follow-up two prospective cohorts patients, examined if this could...
Abstract Objective Even though trimethylamine N-oxide (TMAO) has been demonstrated to interfere with atherosclerosis and diabetes pathophysiology, the association between TMAO major adverse cardiovascular events (MACE) not specifically established in type 2 (T2D). Research Design Methods We examined of plasma concentrations MACE all-cause mortality a single-center prospective cohort consecutively recruited patients T2D. Results The study population consisted 1463 SURDIENE participants (58%...
Abstract Aim To investigate the association between routine use of dipeptidyl peptidase‐4 (DPP‐4) inhibitors and severity coronavirus disease 2019 (COVID‐19) infection in patient with type 2 diabetes a large multicentric study. Materials Methods This study was secondary analysis CORONADO on 2449 patients (T2D) hospitalized for COVID‐19 68 French centres. The composite primary endpoint combined tracheal intubation mechanical ventilation death within 7 days admission. Stabilized weights were...
Mechanisms underlying the pro gression of diabetic kidney disease to ESKD are not fully understood.
Abstract Background There is a lack of real‐life data regarding the frequency and predictive factors hypoglycemia in older patients with type 2 diabetes (T2D). This study aimed to determine predictors insulin‐treated T2D. Methods prospective multicenter included 155 T2D aged 75 years ≥2 self‐monitoring blood glucose (SMBG) daily controls. Participants underwent geriatric diabetic assessment received ambulatory blinded continuous monitoring (CGM) for 28 consecutive days FreeStyle Libre Pro®...