A5028314110- Pancreatic function and diabetes
- Diabetes and associated disorders
- Diabetes Management and Research
- Diabetes Treatment and Management
- Renal Transplantation Outcomes and Treatments
- Immune Cell Function and Interaction
- Metabolism, Diabetes, and Cancer
- Adenosine and Purinergic Signaling
- Organ Transplantation Techniques and Outcomes
- COVID-19 Clinical Research Studies
- Mesenchymal stem cell research
- T-cell and B-cell Immunology
- Transplantation: Methods and Outcomes
- Cardiovascular Function and Risk Factors
- Dialysis and Renal Disease Management
- Neurological and metabolic disorders
- Diet and metabolism studies
- Chronic Kidney Disease and Diabetes
- Renal Diseases and Glomerulopathies
- Adipokines, Inflammation, and Metabolic Diseases
- Pancreatitis Pathology and Treatment
- Renal and Vascular Pathologies
- SARS-CoV-2 and COVID-19 Research
- Advanced MRI Techniques and Applications
- Immune cells in cancer
Boston Children's Hospital
2016-2025
Harvard University
2016-2025
University of Milan
2012-2025
ASST Fatebenefratelli Sacco
2017-2025
Brigham and Women's Hospital
2012-2025
Humanitas University
2024
Luigi Sacco Hospital
2018-2023
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
2023
Foundation Jewish Contemporary Documentation Center
2020-2022
Istituto Nazionale Genetica Molecolare
2017-2021
Human clinical trials in type 1 diabetes (T1D) patients using mesenchymal stem cells (MSC) are presently underway without prior validation a mouse model for the disease. In response to this void, we characterized bone marrow-derived murine MSC their ability modulate immune responses context of T1D, as represented NOD mice. comparison mice, BALB/c-MSC mice were found express higher levels negative costimulatory molecule PD-L1 and promote shift toward Th2-like treated addition, transfer from...
Age is a major risk factor in age-related macular degeneration (AMD), but the underlying cause unknown. We find increased Rho-associated kinase (ROCK) signaling and M2 characteristics eyes of aged mice, revealing immune changes aging. ROCK isoforms determine macrophage polarization into M1 subtypes. M2-like macrophages accumulated AMD, not normal eyes, suggesting that these may be linked to degeneration. injected mouse eye exacerbated choroidal neovascular lesions, while ameliorated them,...
A number of clinical trials are underway to test whether mesenchymal stem cells (MSCs) effective in treating various diseases, including type 1 diabetes. Although this cell therapy holds great promise, the optimal source MSCs has yet be determined with respect major histocompatibility complex matching. Here, we examine question by testing ability congenic MSCs, obtained from NOR mouse strain, reverse recent-onset diabetes NOD mice, as well determine immunomodulatory effects vivo.NOR were...
Type 1 diabetes (T1D) is one of the major autoimmune diseases affecting children and young adults worldwide. To date, different immunotherapies tested have achieved insulin independence in <5% treated individuals. Recently, a novel hematopoietic stem cell (HSC)–based strategy has been individuals with new-onset T1D. The aim this study was to determine effects autologous nonmyeloablative HSC transplantation 65 T1D who were enrolled two Chinese centers Polish center, pooled, followed up...
Podocyte injury and resulting albuminuria are hallmarks of diabetic nephropathy, but targeted therapies to halt or prevent these complications currently not available. Here, we show that the immune-related molecule B7-1/CD80 is a critical mediator podocyte in type 2 nephropathy. We report induction B7-1 kidney biopsy specimens from patients with diabetes. Genetic epidemiologic studies revealed association two single nucleotide polymorphisms at gene Furthermore, increased levels soluble...
Immunologically based clinical trials performed thus far have failed to cure type 1 diabetes (T1D), in part because these approaches were nonspecific. Because the disease is driven by autoreactive CD4 T cells, which destroy β transplantation of hematopoietic stem and progenitor cells (HSPCs) has been recently offered as a therapy for T1D. Our transcriptomic profiling HSPCs revealed that are deficient programmed death ligand (PD-L1), an important immune checkpoint, T1D nonobese diabetic (NOD)...
microRNA-21 (miR-21) is the most commonly upregulated miRNA in solid tumors. This cancer-associated microRNA (oncomiR) regulates various downstream effectors associated with tumor pathogenesis during all stages of carcinogenesis. In this study, we analyzed function miR-21 noncancer cells microenvironment to further evaluate its contribution progression. We report that expression immune infiltrate, and particular macrophages, was responsible for promoting growth. Absence tumor- macrophages...
A substantial proportion of patients who have recovered from coronavirus disease-2019 (COVID-19) experience COVID-19-related symptoms even months after hospital discharge. We extensively immunologically characterized COVID-19. In these patients, T cells were exhausted, with increased PD-1+ cells, as compared healthy controls. Plasma levels IL-1β, IL-1RA, and IL-8, among others, also in This altered immunophenotype was mirrored by a reduced ex vivo cell response to both nonspecific specific...
ABSTRACT. The potential effects of islet transplantation on the renal function 36 patients with type I diabetes mellitus and kidney transplants were studied 4 yr follow-up monitoring. Kidney-islet recipients divided into two groups, i.e., successful (SI-K group) (n = 24, fasting C-peptide levels >0.5 ng/ml for >1 yr) unsuccessful (UI-K 12, <0.5 ng/ml). Kidney graft survival rates function, urinary albumin excretion rates, sodium handling compared. Na+/K+-ATPase activity in protocol biopsies...
OBJECTIVE—Our aim was to evaluate the long-term effects of transplanted islets on diabetic macro-/microangiopathy in type 1 kidney-transplanted patients. RESEARCH DESIGN AND METHODS—A total 34 patients underwent islet transplantation and were divided into two groups: successful islet-kidney (SI-K; 21 patients, fasting C-peptide serum concentration &gt;0.5 ng/ml for &gt;1 year) unsuccessful (UI-K; 13 &lt;0.5 ng/ml). Patients cumulative survival, cardiovascular death rate,...