A5087468685- Hepatocellular Carcinoma Treatment and Prognosis
- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
- Pancreatic function and diabetes
- Gastric Cancer Management and Outcomes
- Diabetes and associated disorders
- Cancer Genomics and Diagnostics
- Angiogenesis and VEGF in Cancer
- COVID-19 Clinical Research Studies
- Lung Cancer Treatments and Mutations
- Cancer, Lipids, and Metabolism
- Pancreatic and Hepatic Oncology Research
- Bacterial Identification and Susceptibility Testing
- Cancer Treatment and Pharmacology
- Cancer, Hypoxia, and Metabolism
- SARS-CoV-2 and COVID-19 Research
- Renal cell carcinoma treatment
- Cell Image Analysis Techniques
- Cancer Cells and Metastasis
- Diabetes Management and Research
- Diabetes Treatment and Management
- BRCA gene mutations in cancer
- Renal and related cancers
- Colorectal Cancer Screening and Detection
- Epigenetics and DNA Methylation
University of Milan
2017-2024
Luigi Sacco Hospital
2021-2023
Foundation Jewish Contemporary Documentation Center
2022
Istituto Nazionale Genetica Molecolare
2021
Beth Israel Deaconess Medical Center
2013-2020
Marche Polytechnic University
2008-2017
Azienda Ospedaliero Universitaria Ospedali Riuniti
2013-2016
Ospedali Riuniti di Ancona
2002-2016
Cancer Genetics (United States)
2010-2014
Regional Cancer Center
2010
Although new treatment modalities changed the global approach to hepatocellular carcinoma (HCC), this disease still represents a medical challenge. Currently, therapeutic stronghold is sorafenib, tyrosine kinase inhibitor (TKI) directed against vascular endothelial growth factor (VEGF) family. Previous observations suggested that polymorphisms of VEGF and its receptor (VEGFR) genes may regulate angiogenesis lymphangiogenesis thus tumour control. The aim our study was evaluate role VEGFR in...
In many tumour types serumlactate dehydrogenase (LDH) levels proved to represent an indirect marker of hypoxia, neo-angiogenesis and worse prognosis. As we previously reported LDH is important predictive factor in hepatocellular carcinoma (HCC) patients undergoing transarterial chemoembolization (TACE). Sorafenib represents the therapeutic stronghold advanced HCC patients. a tyrosine kinase inhibitor (TKI) mainly directed against angiogenetic pathway, correlation sorafenib administration...
A substantial proportion of patients who have recovered from coronavirus disease-2019 (COVID-19) experience COVID-19-related symptoms even months after hospital discharge. We extensively immunologically characterized COVID-19. In these patients, T cells were exhausted, with increased PD-1+ cells, as compared healthy controls. Plasma levels IL-1β, IL-1RA, and IL-8, among others, also in This altered immunophenotype was mirrored by a reduced ex vivo cell response to both nonspecific specific...
Lactate dehydrogenase (LDH) represents a predictive factor in colorectal cancer patients treated with the angiogenesis inhibitor PTK/ZK. We explored role of pre-treatment LDH serum levels receiving first-line bevacizumab.Metastatic bevacizumab was eligible. A control group including all consecutive chemotherapy alone also considered. Pre-treatment were collected for cases.Median progression-free survival (PFS) high and low 4.2 8 months, respectively (P=0.0003). Median overall (OS) 19.6 34.9...
Currently, sunitinib represents one of the therapeutic strongholds for renal cell carcinoma, but criteria treatment selection are lacking. We assessed role vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) polymorphisms in prediction clinical outcome metastatic carcinoma (mRCC) patients.A total 84 tumour samples from mRCC patients receiving first-line were tested VEGFR single-nucleotide (SNPs). The SNP results correlated with progression-free survival (PFS) overall...
Abstract Background Weight loss in patients with metabolic syndrome has positive effects on cardiovascular and type 2 diabetes risks, but its peripheral cytokines lipid profiles are still unclear. Aim To determine the of diet-induced weight parameters, lipids cytokine profiles. Methods Eighteen adult males (defined according to IDF 2009) Body Mass Index (BMI) between 25 35 kg/m were subjected a balanced hypocaloric diet for 6 months reach at least 5% body loss. Results After loss,...
Recent studies have shown that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may induce metabolic distress, leading to hyperglycemia in patients affected by disease 19 (COVID-19). We investigated the potential indirect and direct effects of SARS-CoV-2 on human pancreatic islets 10 who became hyperglycemic after COVID-19. Although there was no evidence peripheral anti-islet autoimmunity, serum these displayed toxicity islets, which could be abrogated use...
Patients with type 1 diabetes (T1D) may develop severe outcomes during coronavirus disease 2019 (COVID-19), but their ability to generate an immune response against the SARS-CoV-2 mRNA vaccines remains be established. We evaluated safety, immunogenicity, and glycometabolic effects of acute respiratory syndrome 2 (SARS-CoV-2) in patients T1D. A total 375 (326 T1D 49 subjects without diabetes) who received two doses (mRNA-1273, BNT162b2) between March April 2021 at ASST Fatebenefratelli Sacco...
Abstract Loss of pancreatic beta cells is a central feature type 1 (T1D) and 2 (T2D) diabetes, but therapeutic strategy to preserve cell mass remains be established. Here we show that the death receptor TMEM219 expressed on signaling through its ligand insulin-like growth factor binding protein 3 (IGFBP3) leads loss dysfunction. Increased peripheral IGFBP3 was observed in established at-risk T1D/T2D patients confirmed preclinical models, suggesting dysfunctional IGFBP3/TMEM219 associated...
In many tumor types serum lactate dehydrogenase (LDH) levels is an indirect marker of hypoxia, neo-angiogenesis and worse prognosis. However data about hepatocellular carcinoma (HCC) are lacking in the clinical setting patients undergoing transarterial-chemoembolization (TACE) whom hypoxia may represent a molecular key to treatment failure. Aim our analysis was evaluate role LDH pre-treatment determining outcome for with HCC receiving TACE. One hundred fourteen were available analysis. For...
Sorafenib is a multi-targeted kinase inhibitor with demonstrated activity in renal cell carcinoma (RCC) and hepatocellular (HCC), it currently used for the treatment of these pathologies. Ongoing clinical trials are studying its other malignancies, such as non-small-cell lung cancer (NSCLC). However, no biological marker known to define either sensitivity or resistance drug. Here we report case patient two synchronous tumors, HCC NSCLC, metastases contralateral bone. The was treated...
To assess the effect of a fermented rice-flour obtained from Lactobacillus paracasei CBA L74 in managing infants with moderate to severe atopic dermatitis. Infants dermatitis, aged 6-36 months, were randomly assigned receive once-daily consumption rice flour containing heat-killed probiotic or placebo for 12 weeks as supplementary approach topical treatment. Primary outcome was SCORAD index change baseline weeks; secondary outcomes gut microbiota composition, evaluated by analysis fecal...
PURPOSE: The relationship between germ-line mutations of hMSH2 and hMLH1, microsatellite instability (MSI), loss DNA mismatch repair (MMR) gene expression were studied to formulate an effective selection protocol for patients with suspected hereditary nonpolyposis colorectal cancer who should be offered genetic testing. PATIENTS AND METHODS: Patients eligible analysis hMLH1 selected. Tumor specimens obtained assess MSI MMR expression. RESULTS: Among 37 participated in the study, two missense...
Clinical data indicate that prognostic stratification of radically resected colorectal cancer based on disease stage only may not be always adequate. Preclinical findings suggest stem cells influence the biological behaviour independently from stage: objective study was to assess whether a panel stemness markers were correlated with clinical outcome in II and III colon patients. A 66 analysed thus patients divided into two groups (A B) most clustering manner consistent different time relapse...