A5091275868- Wound Healing and Treatments
- Reconstructive Surgery and Microvascular Techniques
- Diabetic Foot Ulcer Assessment and Management
- Mesenchymal stem cell research
- Surgical Sutures and Adhesives
- Pressure Ulcer Prevention and Management
- Surgical site infection prevention
- Body Contouring and Surgery
- Dermatologic Treatments and Research
- Breast Implant and Reconstruction
- Electrospun Nanofibers in Biomedical Applications
- Clinical practice guidelines implementation
- Cardiac, Anesthesia and Surgical Outcomes
- Tissue Engineering and Regenerative Medicine
- Burn Injury Management and Outcomes
- Digital Imaging in Medicine
- Meta-analysis and systematic reviews
- Periodontal Regeneration and Treatments
- Delphi Technique in Research
- Tendon Structure and Treatment
- Reconstructive Facial Surgery Techniques
- Breast Cancer Treatment Studies
- Bone fractures and treatments
- Biomedical Ethics and Regulation
- Hidradenitis Suppurativa and Treatments
Brigham and Women's Hospital
2016-2025
Harvard University
2016-2025
Harvard University Press
2000-2024
Professional Education and Research Institute
2016-2024
Loma Linda University
2005-2024
Dana-Farber Cancer Institute
2018-2024
Mass General Brigham
2010-2024
University Hospital Heidelberg
2022-2023
Heidelberg University
2020-2023
California Northstate University
2023
Case reports have been a long held tradition within the surgical literature. Reporting guidelines can improve transparency and reporting quality. However, recent consensus-based for case (CARE) are not surgically focused. Our objective was to develop report guidelines.The CARE statement used as basis Delphi consensus. The questionnaire administered via Google Forms conducted using standard methodology. A multidisciplinary group of surgeons others with expertise in were invited participate....
Regeneration of the dermis does not occur spontaneously in adult mammal. The epidermis is regenerated provided there a dermal substrate over which it can migrate. Certain highly porous, crosslinked collagen-glycosaminoglycan copolymers have induced partial morphogenesis skin when seeded with and epidermal cells then grafted on standard, full-thickness wounds guinea pig. A mature nearly physiological dermis, lacked hair follicles but was demonstrably different from scar, were areas as large...
The mechanism of action the Vacuum Assisted Closure Therapy (VAC; KCI, San Antonio, Texas), a recent novel innovation in care wounds, remains unknown. In vitro studies have revealed that cells allowed to stretch tend divide and proliferate presence soluble mitogens, whereas retracted remain quiescent. authors hypothesize application micromechanical forces wounds vivo can promote wound healing through this cell shape-dependent, mechanical control mechanism. created computer model (finite...
Case series have been a long held tradition within the surgical literature and are still frequently published. Reporting guidelines can improve transparency reporting quality. No guideline exists for case series, our recent systematic review highlights fact that key data being missed from such reports. Our objective was to develop series.A Delphi consensus exercise conducted determine items include in guideline. Items included those identified previous on SCARE Guidelines The questionnaire...
The vacuum-assisted closure device is widely used clinically, yet its mechanisms of action are incompletely understood. In this study, the authors designed a partially splinted full-thickness murine model to better understand mechanism device.Full-thickness wounds (n = 10 per group) were excised in diabetic mice and treated with or isolated components: an occlusive dressing, subatmospheric pressure at 125 mmHg (suction), polyurethane foam without downward compression. Results quantified...
Background Intimate partner violence (IPV) is a global social and public health problem, but published literature regarding the exacerbation of physical IPV during coronavirus disease 2019 (COVID-19) pandemic lacking. Purpose To assess incidence, patterns, severity injuries in victims COVID-19 2020 compared with prior 3 years. Materials Methods The demographics, clinical presentation, injuries, radiologic findings patients reporting abuse arising from statewide between March 11 May 3, 2020,...
Unlike conventional reconstruction, facial transplantation seeks to correct severe deformities in a single operation. We report on three patients who received full-face transplants at our institution 2011 operations that aimed for functional restoration by coaptation of all main available motor and sensory nerves. enumerate the technical challenges postoperative complications their management, including episodes acute rejection two patients. At 6 months follow-up, allografts were surviving,...
Abstract Chronic wounds do not heal in an orderly fashion part due to the lack of timely release biological factors essential for healing. Topical administration various therapeutic at different stages is shown enhance healing rate chronic wounds. Developing a wound dressing that can deliver biomolecules with predetermined spatial and temporal pattern would be beneficial effective treatment Here, actively controlled fabricated using composite fibers core electrical heater covered by layer...
Chronic wounds are one of the most devastating complications diabetes and leading cause nontraumatic limb amputation. Despite progress in identifying factors promising vitro results for treatment chronic wounds, their clinical translation is limited. Given range disruptive processes necessary wound healing, different pharmacological agents needed at stages tissue regeneration. This requires development wearable devices that can deliver to critical layers bed a minimally invasive fashion....
Advanced wound scaffolds that integrate active substances to treat chronic wounds have gained significant recent attention. While and advanced functionalities previously been incorporated into one medical device, the wirelessly triggered release of has remained focus many research endeavors. To combine multiple functions including light-triggered activation, anti-septic, angiogenic, moisturizing properties, we developed a 3D printed hydrogel patch encapsulating vascular endothelial growth...
Surgeons are skilled at making complex decisions over invasive procedures that can save lives and alleviate pain avoid complications in patients. The knowledge to make these is accumulated years of schooling practice. Their experience turn shared with others, also via peer-reviewed articles, which get published larger amounts every year. In this work, we review the literature related use Artificial Intelligence (AI) surgery. We focus on what currently available likely come near future both...
Open lower leg fractures with exposed bone or tendon continue to be challenging for plastic surgeons. Microvascular free-tissue transfer increases the ability close wounds, vascularized bone, and prevent amputation, yet remains a complex, invasive procedure significant complication rates, donor-site morbidity, failure rates. This review documents changing treatment protocol in authors' institution these injuries.Two hundred ninety consecutive open tibia-fibula over 12-year period (1992 2003)...
In Brief The vacuum-assisted closure (VAC) device causes microdeformations of the wound surface in contact with foam. Because angiogenesis and matrix metalloproteinase (MMP) activity are altered chronic wounds, we hypothesized that stimulate capillary formation affect MMP activity. A VAC was used to deliver microdeformational therapy (MDWT) wounds 3 debilitated patients. Debrided tissue obtained from areas without foam contact. Microvessel density were determined by immunohistochemistry...