A5026189603- Malaria Research and Control
- Mosquito-borne diseases and control
- Invertebrate Immune Response Mechanisms
- Renal Transplantation Outcomes and Treatments
- Zebrafish Biomedical Research Applications
- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Metalloenzymes and iron-sulfur proteins
- Advanced Memory and Neural Computing
- Microbial Natural Products and Biosynthesis
- Wound Healing and Treatments
- Plant biochemistry and biosynthesis
- Insect Resistance and Genetics
- Aquaculture disease management and microbiota
- Genetics and Neurodevelopmental Disorders
- Viral Infections and Vectors
- Developmental Biology and Gene Regulation
- Neural Networks and Reservoir Computing
- Organ Transplantation Techniques and Outcomes
- Trypanosoma species research and implications
- Organ Donation and Transplantation
- Insect symbiosis and bacterial influences
- Neurological Complications and Syndromes
- Phytochemicals and Medicinal Plants
- Nuclear Receptors and Signaling
Birla Institute of Technology and Science, Pilani
2013-2025
BLK Super Speciality Hospital
2023-2025
University of Ottawa
2007-2024
Max Healthcare
2024
University of Delaware
2023-2024
Indian Institute of Technology Roorkee
2024
Creative Commons
2023
JECRC University
2023
Fortis Memorial Research Institute
2019-2021
M.J.P. Rohilkhand University
2015-2021
The mechanism of action the Vacuum Assisted Closure Therapy (VAC; KCI, San Antonio, Texas), a recent novel innovation in care wounds, remains unknown. In vitro studies have revealed that cells allowed to stretch tend divide and proliferate presence soluble mitogens, whereas retracted remain quiescent. authors hypothesize application micromechanical forces wounds vivo can promote wound healing through this cell shape-dependent, mechanical control mechanism. created computer model (finite...
Epidemiologic studies and clinical description of severe Plasmodium vivax malaria in adults living malaria-endemic areas are rare more attention is needed to understand the dynamics its interaction with immune system. This observational study included 1,091 adult patients admitted medical wards S. P. Medical College associated group hospitals Bikaner, India from September 2003 through December 2005. The diagnosis was established by peripheral blood film (PBF), rapid diagnostic test (RDT),...
Abstract We report 11 cases of severe Plasmodium vivax malaria in Bikaner (western India). Patients exhibited cerebral malaria, renal failure, circulatory collapse, anemia, hemoglobinurea, abnormal bleeding, acute respiratory distress syndrome, and jaundice. Peripheral blood microscopy, parasite antigen–based assays, 18s rRNA gene–based polymerase chain reaction showed the presence P. absence falciparum.
Sudden death is one of the more frequent causes for hemodialysis patients, but underlying mechanisms, contribution arrhythmia, and associations with serum chemistries or dialysis procedure are incompletely understood. To study this, implantable loop recorders were utilized continuous cardiac rhythm monitoring to detect clinically significant arrhythmias including sustained ventricular tachycardia, bradycardia, asystole, symptomatic in patients over six months. Serum tested pre- post-dialysis...
This guideline addresses the use of hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) in patients >18 years with chronic kidney disease (CKD) and anemia South Asia (Bangladesh, Bhutan, Nepal, India, Pakistan, Sri Lanka). It also summarizes recommendations for treatment individual HIF-PHI molecules under two categories: dialysis-dependent non-dialysis-dependent CKD patients. The do not apply to pediatric (≤12 years) adolescent (12 18) or those primary secondary other causes...
Severe Plasmodium vivax malaria in adults has been reported from Bikaner (northwestern India) but the reports on children are scanty. This prospective study was done 303 admitted of malaria. The diagnosis by peripheral blood smear and rapid diagnostic test. Further confirmation severe P. monoinfection polymerase chain reaction (PCR). proportion falciparum, vivax, mixed (P. falciparum vivax) infection 61.01%, 33.99%, 4.95%, respectively. disease present 49.5% (150/303) with malaria, risk...
Pyridoxine-dependent epilepsy (PDE) is a rare disease characterized by mutations in the lysine degradation gene
Abstract Background The mosquito midgut is crucial for digestion and immune interactions. It produces several factors that protect the organ from invading pathogens can limit their propagation. Studies on transcriptome following pathogen exposure have revealed presence of non-canonical genes, such as ABC transporters, whose function in insect immunity remains unexplored. Therefore, this study focuses identifying characterising role transporters Aedes aegypti , a primary arboviral vector....
The occurrence, relation and magnitude of thrombocytopenia in different species malaria are not clearly defined. This study included 1,064 patients admitted with to (platelet count <150,000 /cumm) Plasmodium falciparum (Pf) vivax (Pv) mono infection mixed (Pf + Pv). diagnosis was done by peripheral blood film (PBF) rapid diagnostic test (RDT). Validation polymerase chain reaction (PCR) only severe <20,000 /cumm). breakup 525 (49.34%) Pf, 460 (43.23%) Pv 79 (7.42%) Thrombocytopenia observed...
Abstract Age is well-known to be a significant factor in both disease pathology and response treatment, yet the molecular changes that occur with age humans remain ill-defined. Here, using transcriptome profiling of healthy human male skin, we demonstrate there period significantly elevated, transcriptome-wide expression occurring predominantly middle age. Both pre post this period, appears undergo much smaller, linear increasing Functional analysis transient suggest heightened metabolic...
Malaria parasites transmitted by mosquito bite are remarkably efficient in establishing human infections. The infection process requires roughly 30 minutes and is highly complex as quiescent sporozoites injected with saliva must be rapidly activated the skin, migrate through body, infect liver. This poorly understood for Plasmodium vivax due to low infectivity vitro models. To study this skin-to-liver-stage of malaria, we used quantitative bioassays coupled transcriptomics evaluate parasite...
The Gene Set Enrichment Analysis (GSEA) identifies sets of genes that are differentially regulated in one direction. Many homeostatic systems will include limb is upregulated response to a downregulation another and vice versa. Such patterns poorly captured by the standard formulation GSEA. We describe technique identify groups (which sometimes can be pathways) both up- down-regulated components. This approach lends insights into feedback mechanisms may operate, especially when integrated...
The functionality of many cellular proteins depends on cofactors; yet, they have only been implicated in a minority Mendelian diseases. Here, we describe the first 2 inherited disorders cytosolic iron-sulfur protein assembly system.
Aedes aegypti acts as a vector for several arboviral diseases that impose major socio-economic burden. Moreover, the absence of vaccine against these and drug resistance in mosquitoes necessitates development new control strategies vector-borne diseases. ABC transporters play vital role immunity other cellular processes different organisms may act non-canonical immune molecules arboviruses, however, their mosquito remains unexplored. This study comprehensively analyzed various genetic...
Rationale & ObjectiveThe incidence of arrhythmia varies by time day. How this impacts individuals on maintenance dialysis is uncertain. Our objective was to quantify the relationship with day and timing dialysis.Study DesignSecondary analysis Monitoring in Dialysis study- a multicenter prospective cohort study.Settings ParticipantsLoop recorders were implanted for continuous cardiac monitoring 66 participants follow up 6 months.ExposureTime based 6-hour intervalsOutcomesEvent rates...
Wounds are increasingly important in our aging societies. Pathologies such as diabetes predispose patients to chronic wounds that can cause pain, infection, and amputation. The vacuum assisted closure device shows remarkable outcomes wound healing. Its mechanism of action is unclear despite several hypotheses advanced. We previously hypothesized micromechanical forces heal wounds. To understand better the biological response soft tissue forces, rat ears vivo were stretched their gene...