A5036214570- Burn Injury Management and Outcomes
- Wound Healing and Treatments
- Dermatologic Treatments and Research
- Injury Epidemiology and Prevention
- Cardiac Arrest and Resuscitation
- Climate Change and Health Impacts
- Planarian Biology and Electrostimulation
- Disaster Response and Management
- Pressure Ulcer Prevention and Management
- Laser Applications in Dentistry and Medicine
- Wnt/β-catenin signaling in development and cancer
- Thermal Regulation in Medicine
- Hair Growth and Disorders
- Cellular Mechanics and Interactions
- Traumatic Brain Injury and Neurovascular Disturbances
- Antimicrobial Peptides and Activities
- Heterotopic Ossification and Related Conditions
- Microbial metabolism and enzyme function
- Dupuytren's Contracture and Treatments
- Axon Guidance and Neuronal Signaling
- Trauma and Emergency Care Studies
- Genital Health and Disease
- Heme Oxygenase-1 and Carbon Monoxide
- Mesenchymal stem cell research
- Kruppel-like factors research
The University of Western Australia
2016-2025
Fiona Stanley Hospital
2019-2025
Fiona Wood Foundation
2012-2025
The Kids Research Institute Australia
2019-2024
Queensland Children’s Hospital
2024
Queensland University of Technology
2024
Institute for Respiratory Health
2018-2022
Government of Western Australia Department of Health
2016-2022
Hunter Medical Research Institute
2022
Crawley Hospital
2015-2018
An important histological difference between normal, uninjured dermis and scar tissue such as that found in keloid scars is the pattern (morphological architecture) which collagen deposited arranged. In dermis, bundle architecture appears randomly organized (or a basket weave formation), whereas pathological conditions tissue, bundles are often whorls or hypotrophic more densely packed parallel configuration. case of skin, disables leaving it weaker, stiff with loss optimal functionality....
Abstract In the last decade, advent of 3D printing for tissue engineering and regenerative medicine has engendered great interest those involved in skin repair regeneration. bioprinting allows spatial distribution cells into predefined custom‐made structures to produce living mimics on bench grafting or drug testing. The key aspect lies formulation printable bioinks serving as matrix house cells, alongside an appropriate combination cells. this review, bioink formulations, cell combinations,...
Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease associated with chronic inflammation and tissue remodelling leading to fibrosis, reduced function, respiratory failure death. Bleomycin (Blm)-induced in mice replicates several clinical features of human IPF, including prominent lymphoid aggregates predominantly B-cells that accumulate the adjacent areas active fibrosis. We have shown previously a requirement for development Blm-induced mice. To determine therapeutic...
Dysregulated lipid metabolism underpins many chronic diseases including cardiometabolic diseases. Mass spectrometry-based lipidomics is an important tool for understanding mechanisms of dysfunction and widely applied in epidemiology clinical studies. With ever-increasing sample numbers, single batch acquisition often unfeasible, requiring advanced methods that are accurate robust to batch-to-batch interday analytical variation. Herein, optimized comprehensive targeted workflow plasma serum...
There is a need to develop economical, efficient and widely available therapeutic approaches enhance the rate of skin wound healing. The optimal outcome healing restoration pre-wound quality health. In this study we investigate cellular response biological stimuli using functionalized nanofibers from self-assembling peptide, RADA16. We demonstrate that adding different functional motifs RADA16 base peptide can influence proliferation migration keratinocytes dermal fibroblasts. Relative...
Delayed diagnosis of patients with sepsis or septic shock is associated increased mortality and morbidity. UPLC-MS NMR spectroscopy were used to measure panels lipoproteins, lipids, biogenic amines, amino acids, tryptophan pathway metabolites in blood plasma samples collected from 152 within 48 h admission into the Intensive Care Unit (ICU) where 62 had no sepsis, 71 19 shock. Patients higher concentrations neopterin lower levels HDL cholesterol phospholipid particles comparison nonsepsis...
Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) is a rare but life-threatening cutaneous drug reaction mediated by human leukocyte antigen (HLA) class I-restricted CD8
Abstract Anatomical understanding is critical to medical education. With reduced teaching time and limited cadaver availability, it important investigate how best utilize in vivo imaging supplement anatomical better prepare graduates for the proliferation of point‐of‐care future. To whether using short sessions ultrasonography could benefit students' knowledge clinical application, we conducted a 2‐hour session on abdominal anatomy small groups five six students, both first‐ second‐year...
Abstract Age is well-known to be a significant factor in both disease pathology and response treatment, yet the molecular changes that occur with age humans remain ill-defined. Here, using transcriptome profiling of healthy human male skin, we demonstrate there period significantly elevated, transcriptome-wide expression occurring predominantly middle age. Both pre post this period, appears undergo much smaller, linear increasing Functional analysis transient suggest heightened metabolic...
A double-blind randomized controlled trial with a paired split-scar design compared verapamil, an L-type Ca2+ channel antagonist, and triamcinolone for prevention of keloid recurrence after excision. blocking activity verapamil in cells was explored. One excised per subject each wound half to receive intralesional injections (10 mg/ml) or (2.5 at monthly intervals (4 doses). Interim analysis performed 14 subjects were completed. Survival demonstrated significantly higher 12 months...
The human beta-globin locus control region (LCR) harbors both strong chromatin opening and enhancer activity when assayed in transgenic mice. To understand the contribution of individual DNase I hypersensitive sites (HS) to function LCR, we have mutated core elements within context a yeast artificial chromosome (YAC) carrying entire then analyzed effect these mutations on formation LCR HS expression genes In present study, examined consequences two different HS2 mutations. We first generated...
Abstract Although most chronic wounds possess an underlying pathology, infectious agents also contribute. In many instances, pathogens exist as biofilms forming clusters surrounded by a secreted extracellular substance. We hypothesized that compounds biofilm bacteria may inhibit normal wound healing events including cell proliferation and migration. Conditioned media from two common bacterial species associated with skin tympanic membrane perforations, Staphylococcus aureus Pseudomonas...