A5056451010- Pharmacogenetics and Drug Metabolism
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Cervical Cancer and HPV Research
- Hair Growth and Disorders
- Epilepsy research and treatment
- Dermatologic Treatments and Research
- Drug Transport and Resistance Mechanisms
- Pharmacological Effects and Toxicity Studies
- Nutrition, Genetics, and Disease
- Wound Healing and Treatments
- Computational Drug Discovery Methods
- Dermatology and Skin Diseases
- Autophagy in Disease and Therapy
- Neuroscience and Neuropharmacology Research
- Eicosanoids and Hypertension Pharmacology
- MicroRNA in disease regulation
- Drug-Induced Hepatotoxicity and Protection
- Genomics, phytochemicals, and oxidative stress
- Cannabis and Cannabinoid Research
- BRCA gene mutations in cancer
- Multiple Sclerosis Research Studies
- melanin and skin pigmentation
- RNA regulation and disease
- Kruppel-like factors research
King Khalid University
2017-2025
Universidad de Zaragoza
2024
Institute for Stem Cell Biology and Regenerative Medicine
2024
Christian Medical College & Hospital
2024
Armed Forces Hospital
2023
Sri Siddhartha Medical College
2023
Creative Commons
2023
King Saud University
2021-2022
The University of Western Australia
2017
King Abdulaziz University
2015-2016
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by gradual cognitive decline. Strong antioxidants that inhibit free radicals, such as polyphenols, reduce the likelihood of developing oxidative stress-related degenerative diseases AD. Naringin, flavonoid found in citrus fruit shown to be neuroprotective, damage and minimize histopathological changes caused ischemic reperfusion, enhance long-term memory AD animal models. This work aimed comprehend role naringin defense...
This study aims to determine the level of origin, branching pattern and exits iliohypogastric ilioinguinal nerves in relation psoas major muscle.Additionally, this confirms presence retroperitoneal courses double nerves.We dissected a total 24 (6 male 6 female cadavers).The branching, muscle, absence these or nerves, their course were carefully examined.All images recorded by photographing.In study, we mainly observed variations exits, patterns, course.The nerve was absent 2 cases (8.3%).In...
Background Ranolazine (Rn), an antianginal agent, acts in the central nervous system and has been used as a potential treatment agent for pain epileptic disorders. Alzheimer’s disease (AD) is one of most prevalent neurodegenerative diseases leading factor dementia elderly. Aim We examined impact Rn on scopolamine (Sco)-induced rats. Methods Thirty-two albino male rats were divided into four groups: control, Rn, Sco, + Sco. Results A significant decrease escape latency Morris water maze test...
A double-blind randomized controlled trial with a paired split-scar design compared verapamil, an L-type Ca2+ channel antagonist, and triamcinolone for prevention of keloid recurrence after excision. blocking activity verapamil in cells was explored. One excised per subject each wound half to receive intralesional injections (10 mg/ml) or (2.5 at monthly intervals (4 doses). Interim analysis performed 14 subjects were completed. Survival demonstrated significantly higher 12 months...
Background and Objectives: Hypertension (HTN) constitutes a significant global health burden, yet the specific genetic variant responsible for blood pressure regulation remains elusive. This study investigates basis of hypertension in Jordanian population, focusing on gene variants related to ion channels transporters, including KCNJ1, WNK1, NPPA, STK39, LUC7L2, NEDD4L, NPHS1, BDKRB2, CACNA1C. Materials Methods: research involved 200 hypertensive patients 224 healthy controls. Whole samples...
Arthritis is a leading cause of economic loss in livestock farming including sheep. This study examined the changes gene expression, antioxidants, pro-inflammatory cytokines, acute-phase proteins (APPs), hormonal assays and iron profiles linked to sheep arthritis, as well diagnostic utility these markers. Blood samples were obtained from 30 apparently healthy rams with arthritis for expression biochemical analyses. Gene intensities much higher arthritis-affected than ones genes IL-1α, IL-1β,...
Background and Objectives: Epilepsy, known as an unprovoked seizure, arises from the human brain. Genetics plays a fundamental role in development progression of disorder. This study aimed to investigate influence voltage-gated K+ channels on risk epilepsy. Materials Methods: Several genetic variants were examined using PCR sequencing. case–control was conducted 296 individuals who diagnosed with epilepsy, addition 293 healthy participants. Results: revealed that within KCNAB1, both...
Background and Objectives: Alopecia areata (AA) is a common cell-mediated autoimmune disease of the hair follicle that results in loss patches, affecting males females all ages ethnicities. Although its etiology not fully understood, AA hypothesized to have multifactorial basis with strong genetic association. This study aims replicate association several risk loci Jordanian population for first time. Materials Methods: Genomic DNA samples 152 patients 150 control individuals were extracted...
This study purpose was to determine the gene expression as well serum profile of acute phase proteins (APPs) and hormonal indicators linked Barki sheep’s susceptibility postpartum issues. Three equal-sized groups (each with fifty ewes) were created from blood 150 adult ewes: control group (CG), inflammatory disorders (IPG), non-inflammatory (NIPG). The levels oxidative stress (PGC-1α, SIRT1, GCLC, GCLM, EPAS1) metabolic (FBXL12, KPNA7, LRRK1) genes significantly higher in sheep than...
Substance Use Disorder (SUD) is a severe global problem that influenced by both environmental and genetic factors. The etiology of addiction can be complex overlapping. This study aimed to investigate the association between two genes, ADH5 ALDH1A1, drug in Jordanian males. included 496 addicted patients healthy controls Arab descent. participants were identified as males with dependence on substances such amphetamines, synthetic cannabinoids, benzodiazepines, alcohol, opiates, cocaine,...
Abstract Background Like other complex diseases including drug addiction, genetic factors can interfere with the disease. In this study, three opioid genes ( OPRM1 , OPRD1, and OPRK1 ) were examined for an association addiction among Jordanian males. Methods The study involved 498 addicts, in addition to 496 healthy controls all from Arab descent. Results findings showed that rs1799971 of gene was both alleles genotypes P -values = 0.002 0.01, respectively. addition, a significant between...
Abstract Purpose The study aimed to test the validity and reliability of Arabic version sedentary behavior questionnaire (SBQ). Methods A total 624 university students (273 males; 351 females, mean age = 20.8 years) were recruited from Taibah University, Madinah, Saudi Arabia. For criterion constructive ( n 352), SBQ was compared with sitting time International Physical Activity Questionnaire-short form (IPAQ-SF) Questionnaire-long (IPAQ-LF). concurrent validity, English versions given...
Vanillic acid (VA) exhibited antioxidant and neuroprotective properties in some neurodegenerative disorders. So, the current study examined potential of VA as an antiepileptic agent pentylenetetrazole (PTZ)-induced epileptic rats prospective role Insulin like growth factor-1 (IGF-1) nuclear factor-2 erythroid-related (Nrf2)/heme oxygenase-1 (HO-1) pathway this respect. Thirty male albino were equally subdivided into 3 groups; (1) normal control (NC) group, (2) PTZ-group: received PTZ (50...
The current study investigated the effects of stevia extracts on a PTZ-induced epileptic rat model and its potential mechanism. Thirty male Sprague-Dawley rats were equally subdivided into 3 groups; (1) normal control (NC) group, (2) PTZ-group: received PTZ (50 mg/kg, i.p. every other day) for 2 weeks, (3) PTZ+ Stevia group: (200 mg/kg orally daily) 4 weeks (2 before start treatment with administration). first jerk latency seizure score assessed in rats. Also, brain tissue samples collected...
Present study is carried out to check the effect of iron oxide nanoparticles (IONPs) on mitigating heavy metal (HM) stress in wheat. For this purpose, IONPs were used an attempt ameliorate cadmium wheat plants. synthesized by using husk Cocos nucifera. The characterized SEM and particle size analyzer. Wheat seedlings treated with 10–1000 mg/L IONPs. selected concentrations (100, 300, 500 mg/L) for next experiment pot soil drench irrigation. Growth parameters (shoot length, root number roots,...
Introduction Diabetes is a global disease, commonly complicated by neuropathy. The spinal cord reacts to diabetes neuronal apoptosis, microglial activation, and astrocytosis, with disturbance in glial Nuclear factor erythroid 2-related factor/Heme oxygenase-1 (Nrf2/HO-1) kappa-light-chain-enhancer of activated B cells (NF-kB) signaling. Curcumin, bioactive natural substance, showed neuroprotective role many diseases. However, its the treatment diabetic central neuropathy underlying...
Malaria has been appraised as a significant vector-borne parasitic disease with grave morbidity and high-rate mortality. Several challenges have confronting the efficient diagnosis treatment of malaria.
The process of vascular formation, also known as angiogenesis, primarily relies on endothelial cell proliferation, migration, and invasion. In recent years, it has been discovered that synthetic cannabinoids (SCs) may potentially impact angiogenic processes within the body. We evaluated cannabinoid (R)-5-Fluoro-ADB proliferation rate angiogenesis in Human Cerebral Microvascular Endothelial Cells (hBMECs).
Introduction: Administration of high doses acetaminophen (APAP) results in liver injury. Oxidative stress and iron overload play roles the pathogenesis APAP-induced hepatotoxicity. The present study assessed potential hepatoprotective effects phytic acid (PA), a natural antioxidant chelator, on hepatotoxicity possible underlying mechanism through its CYP2E1 gene expression, homeostasis, oxidative stress, SIRT -1 expression levels. Methods: Twenty-four adult male albino mice were used this...