A5101514470- Nitric Oxide and Endothelin Effects
- Melamine detection and toxicity
- Cancer-related molecular mechanisms research
- GABA and Rice Research
- Renal and Vascular Pathologies
- Advances in Cucurbitaceae Research
- Dialysis and Renal Disease Management
- Nigella sativa pharmacological applications
- Alzheimer's disease research and treatments
- Aluminum toxicity and tolerance in plants and animals
- Paraquat toxicity studies and treatments
- Neurological Disease Mechanisms and Treatments
- RNA modifications and cancer
- Cancer Cells and Metastasis
- Curcumin's Biomedical Applications
- Medicinal Plants and Neuroprotection
- Nephrotoxicity and Medicinal Plants
- Histone Deacetylase Inhibitors Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Mesenchymal stem cell research
- Pregnancy and preeclampsia studies
- Chemotherapy-induced organ toxicity mitigation
- Epigenetics and DNA Methylation
- Metastasis and carcinoma case studies
- Graphene and Nanomaterials Applications
Mansoura University
2014-2024
Suez University
2023-2024
Galala University
2023
German Cancer Research Center
2020
Heidelberg University
2020
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by gradual cognitive decline. Strong antioxidants that inhibit free radicals, such as polyphenols, reduce the likelihood of developing oxidative stress-related degenerative diseases AD. Naringin, flavonoid found in citrus fruit shown to be neuroprotective, damage and minimize histopathological changes caused ischemic reperfusion, enhance long-term memory AD animal models. This work aimed comprehend role naringin defense...
Melamine (ML), a chemical substance of high nitrogen content, is used as food adulterant. Former evidences implied that ML could induce variety toxic effects including neurotoxicity and cognitive impairment. Therefore, the aim this study was to delineate protective effect nootkatone (NK) against ML-induced neural adverse effects. Rats were orally pretreated with NK (5 10 mg/kg) prior oral administration (700 for period 28 days. Our findings unveiled remarkable alleviating on MK-induced...
Cisplatin (CP) is a conventional chemotherapeutic agent with serious adverse effects. Its toxicity was linked to the stimulation of oxidative stress and inflammation. As result, this study explored protective effect baicalein alpha-tocopherol in nephrotoxicity induced by cisplatin. Until receiving an intraperitoneal injection CP (3 mg/kg BW), rats were given orally 100 for seven days or/and single α-tocopherol 250 mg/kg. Renal function tested explore whether have any beneficial effects;...
To investigate the renoprotective, antioxidant, and anti-inflammatory impact of a combination SPL ZnO-NPs to combat against chronic kidney disease (CKD).In total, 50 males rats were distributed into 5 groups (10 each); normal group, adenine sulfate (0.25% in diet for 10 days) (CKD) group. After last dose sulfate, divided three groups: + Adenine group; treated orally by mixing (20 mg/kg/day) chow 8 weeks, injected intraperitoneally with (5 mg/kg) times weekly same previous doses weeks.Each...
Targeting of endothelin system genes is a promising strategy in cancer therapy. The modulation these was explored during colorectal (CRC) liver metastasis and vitro, when panel CRC tumor cell lines exposed to the demethylating agent decitabine. CC531 rat model mimicking used for re-isolation analysis DNA methyltransferases (DNMTs) by microarray. To mimic effects caused methylation changes, seven treated with Three were intensively modulated at mRNA level cells colonization. An influence from...
Pumpkin has received significant attention due to its nutritional compounds that have antioxidant, antifatigue, and anti‐inflammatory effects. This study is aimed at assessing the antidepressant‐like effect of L. Cucurbita pepo , sweet pumpkin, in an animal model chronic unpredictable mild stress (CUMS) investigating on histological structure hippocampus compared fluoxetine. Forty male albino rats assigned into negative control, positive control (CUMS), Flu‐treated pumpkin‐treated groups ( n...
Endothelin system members including endothelin-1, endothelin-2, endothelin-3, endothelin receptors, and converting enzyme are considered major regulating factors in cancer cell biology microenvironment. Endothelins of the matrix metalloproteinase superfamily proteases, which released from pre-proteins, bind to their receptors with differential affinity, degraded following cellular uptake. For structural similarity, endothelin-2 endothelin-3 can be regarded as natural competitors for...