A5010490825- Urological Disorders and Treatments
- Nanoparticle-Based Drug Delivery
- Chemotherapy-induced organ toxicity mitigation
- Mesenchymal stem cell research
- Inflammasome and immune disorders
- Liver Disease Diagnosis and Treatment
- Curcumin's Biomedical Applications
- Nanoparticles: synthesis and applications
- Advanced Glycation End Products research
- Pancreatic function and diabetes
- Retinal Diseases and Treatments
- Vitamin C and Antioxidants Research
- Drug-Induced Hepatotoxicity and Protection
- Pharmacological Effects of Natural Compounds
- Urinary and Genital Oncology Studies
- Drug Solubulity and Delivery Systems
- Hormonal Regulation and Hypertension
- Advanced Drug Delivery Systems
- Bee Products Chemical Analysis
- Tissue Engineering and Regenerative Medicine
- Diabetes Treatment and Management
- Advancements in Transdermal Drug Delivery
- Computational Drug Discovery Methods
- Nigella sativa pharmacological applications
- Organ Transplantation Techniques and Outcomes
Almaarefa University
2020-2025
Mansoura University
2016-2025
Alfaisal University
2015-2025
Children's Hospital Mansoura University
2024
Al-Azhar University
2021-2023
Central Asian University
2021-2022
Alma College
2021
Montreal Children's Hospital
2007-2019
McGill University
2007-2019
King's College - North Carolina
2019
Alzheimer's disease (AD) is a devastating neurological condition characterized by cognitive decline, motor coordination impairment, and amyloid plaque accumulation.The underlying molecular mechanisms involve oxidative stress, inflammation, neuronal degeneration.This study aimed to investigate the therapeutic
Abstract Background Diabetic foot ulceration is a serious chronic complication of diabetes mellitus characterized by high disability, mortality, and morbidity. Platelet-rich plasma (PRP) has been widely used for diabetic wound healing due to its content growth factors. However, application limited the rapid degradation The present study aimed evaluate efficacy combined adipose-derived mesenchymal stem cells (ADSCs) PRP therapy in promoting relation Notch signaling pathway. Methods Albino...
Retinal hyperpermeability and subsequent macular edema is a cardinal feature of early diabetic retinopathy (DR). Here, we investigated the role bioactive lipid metabolites, in particular 12/15-lipoxygenase (LOX)-derived this process. LC/MS lipidomic screen human retinal endothelial cells (HRECs) demonstrated that 15-HETE was only significantly increased metabolite (2.4 ± 0.4-fold, P = 0.0004) by high glucose (30 mM) treatment. In presence arachidonic acid, additional eicosanoids generated...
Exposure to aluminum chloride (AlCl3) induces progressive multiregional neurodegeneration in animal models by promoting oxidative stress and neuroinflammation. The current study was designed assess the potential efficacy of natural antioxidants celastrol thymoquinone (TQ) for alleviating AlCl3-induced psychomotor abnormalities oxidative-inflammatory burden male albino rats. Four treatment groups were compared: (i) a vehicle control group, (ii) AlCL3 group receiving daily intraperitoneal...
To achieve the best treatment of skin cancer, drug penetration inside deepest layers is an important scientific interest. We designed ethosome formulation that serves as a carrier for metformin and measured in vitro permeation. also aimed to measure antitumor activity optimal ethosomal preparation when applied topically chemically induced cancer mice. utilized statistical Box–Behnken experimental design three variables at levels: lecithin concentration, cholesterol concentration mixture...
In cancer management, drug resistance remains a challenge that reduces the effectiveness of chemotherapy. Several studies have shown curcumin resensitizes cells to chemotherapeutic drugs overcome resistance. present study, we investigate potential therapeutic role in regulating proliferation drug-resistant cancers. Six drug-sensitive (MCF7, HCT116, and A549) -resistant (MCF7/TH, HCT116R, A549/ADR) cell lines were treated with followed by an analysis cytotoxicity, LDH enzyme, total reactive...
Quercetin (QtN) displays low systemic bioavailability caused by poor water solubility and instability. Consequently, it exerts limited anticancer action in vivo. One solution to increase the efficacy of QtN is use appropriate functionalized nanocarriers that preferentially target deliver drug tumor location. Herein, a direct advanced method was designed develop water-soluble hyaluronic acid (HA)-QtN-conjugated silver nanoparticles (AgNPs). HA-QtN reduced nitrate (AgNO3) while acting as...
Gefitinib (GFT) is a tyrosine kinase inhibitor drug used as first-line treatment for patients with advanced or metastatic non-small cell lung, colon, and breast cancer. GFT exhibits low solubility hence oral bioavailability, which restricts its clinical application. One of the most important trends in overcoming such problems use vesicular system. Cubosomes are considered one systems to improve bioavailability. In this study, cubosomal nanoparticles (GFT-CNPs) were prepared by emulsification...
Itraconazole (ITZ) is a triazole antifungal agent characterized by broad-spectrum activity against fungal infections. The main drawback of ITZ, when applied topically, the low skin permeability due to stratum corneum, outermost layer skin, which represents barrier for drug penetration. Therefore, this study aimed prepare itraconazole as transferosomes (ITZ-TFS) overcome function skin. ITZ-TFSs were prepared thin lipid film hydration technique using different surfactants, sodium lauryl...
Diabetic retinopathy (DR) is a serious microvascular complication of diabetes mellitus. Mesenchymal stem cells are currently studied as therapeutic strategy for management DR. Exosomes, considered promising cell-free therapy option, display biological functions similar to those their parent cells. In retinal development, Wnt/b-catenin signaling provides key cues functional progression. The present study aimed evaluate the potential efficacy bone marrow-derived mesenchymal cell-derived...
Abstract Background Colorectal cancer (CRC) is a type of that affects the colon or rectum and occurs in individuals over age 50, although it can affect people all ages. Quercetin flavonoid, which plant pigment with antioxidant anti-inflammatory properties. Some studies have explored potential quercetin as an adjuvant therapy to enhance effectiveness chemotherapy radiation therapy. Methodology In proposed work, nano-biomaterials solid lipids such stearic acid (SA) tripalmitin (TpN) well...
Lipopolysaccharide (LPS), a constituent of the outer membrane Gram-negative bacteria, is powerful inducer systemic inflammation and has been extensively utilized in experimental models to simulate inflammatory responses septic disorders. Recent research indicates that oxytocin (OXY), neuropeptide typically linked social bonding reproductive functions, may influence processes. This work examines impact OXY on LPS-induced testicular damage, aiming elucidate its therapeutic potential addressing...
Background/purpose: Pediatric surgery topics are typically not included in the undergraduate programs of developing nations. The medical school curriculum can impact career paths future doctors. objective this research is to assess understanding recent graduates regarding pediatric as a separate specialty.Methods: A cross sectional online survey study that was conducted using pre-tested questionnaire which distributed between Mansoura Manchester program fresh over duration 3 months. recorded...
Ankle joint fractures account for 10.2% of all fractures. It has been hypothesized that mobilizing the ankle is a crucial intervention improving balance and range motion (ROM). The current study explores impact incorporating mobilization, training, physical therapy exercises into home-based program on pain, ROM, health-related quality life (HRQoL), peak muscle torque in patients with disability following road traffic accidents (RTAs). In this single-blinded, randomized controlled trial, 60...