Favipiravir, molnupiravir, and ritonavir have been recently approved as the first oral antivirals for treatment of SARS-CoV-2 viral infections. Their combination was reported in several clinical studies, alternatively, to enhance eradication improve patient's recovery times rates. Being all orally administered, therefore, development new sensitive validated methodologies their simultaneous determination is a necessitate. In proposed research, sensitive, selective, simple high-performance...

Following the spread of COVID-19 pandemic crisis, a race was initiated to find successful regimen for postinfections. Among those trials, recent study declared efficacy an antiviral combination favipiravir (FAV) and molnupiravir (MLP). The combined helped in 60% eradication SARS-CoV-2 virus from lungs studied hamster models. Moreover, it prevented viral transmission cohosted sentinels. Because both medications are orally bioavailable, coformulation FAV MLP can be predicted. developed is...

An innovative polymer-based electro-sensor decorated with Tb nanoparticles has been developed for the first time. The fabricated sensor was utilized trace determination of favipiravir (FAV), a recently US FDA-approved antiviral drug treatment COVID-19. Different techniques, including ultraviolet-visible spectrophotometry (UV-VIS), cyclic voltammetry (CV), scanning electron microscope (SEM), X-ray Diffraction (XRD) and electrochemical impedance spectroscopy (EIS), were applied...

The COVID-19 pandemic has encouraged the search for novel antiviral medications. Recently, molnupiravir (MOL) been approved as an oral to manage COVID-19. Thus, development of sensitive and cost-effective methods quantification MOL in real plasma samples (pharmacokinetic) pharmaceutical tablets is required. Herein, we present fabrication fluorescent polyamine quantum dots (PA@CQDs) fabricated from apricots using one step synthesis analysis MOL. relative fluorescence intensity (RFI)...

An ion chromatography technique with conductivity detection was selected as an analytical tool for the simultaneous indirect determination of sodium sulfate, potassium and magnesium sulfate via their respective cations. The method developed validated quantitative assay inorganic salts under study in oral pharmaceutical dosage forms. Chromatographic separation achieved on a Dionex®IonPac® CS16 column (250 × 5 mm) using gradient elution method. A mobile phase-A consisting methane sulfonic acid...

Four eco-friendly, cost-effective, and fast stability-indicating UV-VIS spectrophotometric methods were validated for cefotaxime sodium (CFX) determination either in the presence of its acidic or alkaline degradation products. The applied used multivariate chemometry, namely, classical least square (CLS), principal component regression (PCR), partial (PLS), genetic algorithm-partial (GA-PLS), to resolve analytes' spectral overlap. zone studied mixtures was within range from 220 320 nm at a 1...

Terbium- and nitrogen-doped carbon quantum dots (Tb,N@CQDs) were greenly created employing microwave synthesis from plum juice with terbium nitrate. The of Tb,N@CQDs was fast (7 min) a high yield (35.44%). fully characterized using transmission electron microscopy, Zeta potential analysis, fluorescence, ultraviolet spectroscopy. Omadacycline (OMC) is broad-spectrum tetracycline that has been recently approved by the United States Food Drug Act (FDA) in October 2018. OMC first oral...

Abstract Loratadine (LoR) is a highly lipophilic and practically insoluble in water, hence having low oral bioavailability. As it formulated as topical gel, competitively binds with the receptors, thus reducing side-effects. The objective of this study was to prepare LoR loaded nanosponge (LoR-NS) gel for delivery. Nine different formulations emulsion were prepared by solvent evaporation method polyvinyl alcohol (PVA), ethyl cellulose (EC), dichloromethane (DCM). Based on 3 2 Full Factorial...

Abstract Verapamil hydrochloride (VRP), an antihypertensive calcium channel blocker drug has limited bioavailability and short half-life when taken orally. The present study was aimed at developing cubosomes containing VRP for enhancing its targeting to brain cluster headache (CH) treatment as off-label use. Factorial design conducted analyze the impact of different components on entrapment efficiency (EE%), particle size (PS), zeta potential (ZP), percent release. Various in-vitro...

Abstract Atopic dermatitis (AD) is a persistent, inflammatory skin condition that impacts approximately 15 to 20% of children and 1 3% adults globally. Common manifestations include papules, papulovesicular, brown or red patches with swelling, crusting, flaking. Therefore, the drug abrocitinib (ABR) was approved by US FDA as an oral treatment for atopic dermatitis. The present study outlines development innovative, thermostable, pH‐stable organic solvent‐free nitrogen‐doped carbon dots...

Fluorescence spectroscopy is a sensitive, simple, and economic analytical tool with high through output suitable for the Quality Control of COVID-19 drugs.

The endemicity of the pandemic coronavirus disease 2019 (COVID-19) infection proved to be transitional only. Spikes are forming again in 2023, and high expectations returning for reinfections viral mutations. Molnupiravir (MOL) has been approved as an oral antiviral drug treatment COVID-19 causative virion. Therefore, development ultrasensitive, instantaneous, cost-effective method quantification MOL real plasma samples formulated dosage form mandatory. proposed approach is based on...

A novel green fluorimetric approach for quantifying avapritinib in biological fluids (pharmacokinetic study).

Abstract Background Colorectal cancer (CRC) is a type of that affects the colon or rectum and occurs in individuals over age 50, although it can affect people all ages. Quercetin flavonoid, which plant pigment with antioxidant anti-inflammatory properties. Some studies have explored potential quercetin as an adjuvant therapy to enhance effectiveness chemotherapy radiation therapy. Methodology In proposed work, nano-biomaterials solid lipids such stearic acid (SA) tripalmitin (TpN) well...

Gastrointestinal stromal tumors (GISTs) account for about 80% of the mesenchymal GI tract. About 5000-6000 patients are diagnosed in United States (US) alone, and up to 14.5 cases per million discovered Europe annually. Avapritinib (AVP) is a potent selective targeted medication that has been recently approved, by US Food Drug Administration, 2020 treatment GISTs. AVP currently considered first-line mutant GIST, which resistant other medications. This turn stimulates need fast, green,...

The herbal extracts of four traditional plants; namely Gymnema sylvestre leaves, Garcinia cambogia fruits, Cleome droserifolia and Nigella sativa seeds, were identified for their main constituents using UHPLC/QTOF-MS/MS. Then, a pharmacology-based analysis molecular docking verification established targeting the evaluation each individual extract antidiabetic/anti-obesity potential besides safety. Streptozotocin-induced diabetic rats used to evaluate antiobesity insulinotropic effects...

ABSTRACT Utilizing chromatography with green chemistry principles helps minimize harm to people and the environment. Since its recent release, new combination of tazarotene (TAZ) halobetasol propionate has gained popularity. Crisaborole (CRB) recently also shown potential for treating psoriasis can be coformulated drugs like TAZ anthralin. Currently, no method been reported simultaneous determination these drugs. In addition, an environmentally friendly high‐performance liquid (HPLC) any...

Background/Objectives: Hyperlipidemia is a silent threat lurking in the bloodstream of millions worldwide. The nano-based platform has emerged as promising drug delivery technology. Repaglinide, an anti-diabetic drug, was investigated recently antihyperlipidemic candidate that could supersede available drugs. Our goal to optimize albumin-based nanoparticles loaded with Repaglinide for parenteral and conduct silico vivo studies explore efficacy management hyperlipidemia along its effect....