A5082553335- Synthesis and Biological Evaluation
- Computational Drug Discovery Methods
- Pharmacogenetics and Drug Metabolism
- Synthesis and biological activity
- Chemical synthesis and alkaloids
- thermodynamics and calorimetric analyses
- Phytochemicals and Antioxidant Activities
- Pharmacology and Obesity Treatment
- HIV Research and Treatment
- Natural Antidiabetic Agents Studies
- Acne and Rosacea Treatments and Effects
- Click Chemistry and Applications
- Antiplatelet Therapy and Cardiovascular Diseases
- Cancer therapeutics and mechanisms
- Diet, Metabolism, and Disease
- Oxidative Organic Chemistry Reactions
- HIV/AIDS drug development and treatment
- Vanadium and Halogenation Chemistry
- Cholinesterase and Neurodegenerative Diseases
- Essential Oils and Antimicrobial Activity
- Synthesis and Reactions of Organic Compounds
- Hepatitis C virus research
Sinai University
2023-2025
German University in Cairo
2018
Abstract Thrombosis is the leading cause of illness and mortality worldwide, posing a serious risk to human health life. Because antithrombotic drugs can prevent beginning progression thrombotic disorders, they are essential in management diseases. The substantial side effects unsatisfactory efficacy present stimulate search for novel, effective, safer therapies. Natural synthetic coumarins have been shown action, specifically anticoagulation, antiplatelet aggregation. In particular,...
The herbal extracts of four traditional plants; namely Gymnema sylvestre leaves, Garcinia cambogia fruits, Cleome droserifolia and Nigella sativa seeds, were identified for their main constituents using UHPLC/QTOF-MS/MS. Then, a pharmacology-based analysis molecular docking verification established targeting the evaluation each individual extract antidiabetic/anti-obesity potential besides safety. Streptozotocin-induced diabetic rats used to evaluate antiobesity insulinotropic effects...
Here we report a series of potent anti-HCV agents bearing symmetrical benzidine l-prolinamide backbone with different capping groups including alkyl/aryl carbamates natural and unnatural valine leucine amino acids. All compounds were investigated for their inhibitory activity in an HCV replicon assay on genotype 1b. The novel share some chemical clinical attributes commercially available NS5A inhibitors. Compounds 5 6 residue ethyl isobutyl showed EC50 values the picomolar range low toxicity...