A5049191715- Aluminum toxicity and tolerance in plants and animals
- Medicinal Plants and Neuroprotection
- Curcumin's Biomedical Applications
- Biochemical effects in animals
- Alzheimer's disease research and treatments
- Tryptophan and brain disorders
- Vitamin C and Antioxidants Research
- Medicinal Plants and Bioactive Compounds
- Biochemical Analysis and Sensing Techniques
- Coenzyme Q10 studies and effects
- Neuroinflammation and Neurodegeneration Mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Attention Deficit Hyperactivity Disorder
- Hydrogen's biological and therapeutic effects
- Cholinesterase and Neurodegenerative Diseases
- Nigella sativa pharmacological applications
- GABA and Rice Research
- MicroRNA in disease regulation
- Trace Elements in Health
- Neurological Disease Mechanisms and Treatments
- Ginkgo biloba and Cashew Applications
- Plant biochemistry and biosynthesis
- Tea Polyphenols and Effects
- Conducting polymers and applications
- Cholesterol and Lipid Metabolism
Al-Azhar University
2017-2025
Iraqi University
2024-2025
Al-Ayen University
2024
Thi Qar University
2024
Alzheimer's disease (AD) is a neurodegenerative disorder that associated with abnormal cognition. AD aided in its initiation and progression by hereditary environmental factors. Aluminum (Al) neurotoxic agent causes oxidative stress, which linked to progression. Additionally, Nrf2/HO-1, APOE4/LRP1, Wnt3/β-catenin, TLR4/NLRP3 are the main signaling pathways involved pathogenesis. Several phytochemicals promising options delaying evolution.This study aimed at studying neuroprotective effects...
Both thymoquinone (TQ) and thymol (T) have been proved to possess a positive impact on human health. In this research, we aimed investigate the effect of these compounds separately together Attention-deficit/hyperactivity disorder (ADHD)-like behavior induced by monosodium glutamate (MSG) in rats. Forty male, Spargue Dawley rat pups (postnatal day 21), were randomly allocated into five groups: Normal saline (NS), MSG, MSG+TQ, MSG+T, MSG+TQ+T. MSG (0.4 mg/kg/day), TQ (10 mg/kg/day) T (30...
Parkinson's disease (PD) is a progressive neurodegenerative disorder affecting the substantia nigra where functions controlling body movement take place. Manganese (Mn) overexposure linked to neurologic syndrome resembling PD. Sesamol, thymol, wheat grass (WG), and coenzyme Q10 (CoQ10) are potent antioxidants, anti-inflammatory, anti-apoptotic nutraceuticals. We investigated potential protective effects of these nutraceuticals alone or in combinations against MnCl2-induced PD rats. Seven...
Introduction: Aluminium (Al) is accumulated in the brain causing neurotoxicity and neurodegenerative disease like Alzheimer's (AD), multiple sclerosis, autism epilepsy. Hence, attenuation of Al-induced has become a "hot topic" looking for an intervention that slow down progression diseases. Objective: Our study aims to introduce new strategy hampering aluminum chloride (AlCl3)-induced using combination sesamol with probiotic bacteria; Lactobacillus rhamnosus (L. rhamnosus) also test their...
The current study investigated the neuroprotective activity of some drugs and nutriceuticals with antioxidant anti-inflammatory potential on pathogenesis Parkinson's disease (PD). Rats were categorized into seven groups: received tween80 daily for 5 weeks as a control group, MnCl2 (10 mg/kg, i.p) either alone (group II) or in combination vinpocetine (VIN) (20 mg/kg) III), punicalagin (PUN) (30 IV), niacin (85 V), vitamin E (Vit E) (100 VI) their VII). Motor activities was examined using...
Monosodium glutamate (MSG) is one of the most widely used food additives. However, it has been linked to protein malnutrition (PM) and various forms toxicities such as metabolic disorders neurotoxic effects. The current study first explore association between MSG, PM, induced brain injury similar attention-deficit/hyperactivity disorder (ADHD). Moreover, we determined underlying mechanistic protective pathways morin hydrate (MH)-a natural flavonoid with reported multiple therapeutic...
Alzheimer's disease (AD) is a devastating illness with limited therapeutic interventions. The aim of this study to investigate the pathophysiological mechanisms underlying AD and explore potential neuroprotective effects cocoa, either alone or in combination other nutraceuticals, an animal model aluminum-induced AD. Rats were divided into nine groups: control, aluminum chloride (AlCl3) alone, AlCl3 cocoa vinpocetine (VIN), epigallocatechin-3-gallate (EGCG), coenzyme Q10 (CoQ10), wheatgrass...
Oxalis corniculata (O. corniculata) is a member of Oxalidaceae family, widely distributed in Asia, Europe, America, and Africa, used extensively as food its traditional folkloric uses include management epilepsy, gastric disorders, neurodegenerative diseases, together with use enhancing health. Numerous pharmacological benefits O. are linked to anti-inflammatory antioxidant abilities. One the most prevalent disorders Alzheimer's disease (AD) which neuroinflammation oxidative stress main...
Manganism, a central nervous system dysfunction correlated with neurological deficits such as Parkinsonism, is caused by the substantial collection of manganese chloride (MnCl
Attention deficit/hyperactivity disorder (ADHD) is a neurodevelopmental condition affecting cognitive and social functions all over childhood. Monosodium glutamate (MSG) common food additive associated with ADHD-like symptoms in children. Nutraceuticals, like sesamol (SE) astaxanthin (AST), or physical activity (PHA) were reported to possess beneficial effects on human health. Meanwhile, still their neuroprotective effect against ADHD has been poorly investigated. This study aimed...
Background Obesity and weight gain have become major problems worldwide. Thus, several forms of alternative intense sweeteners are extensively used, offering a non-caloric sweet taste. To the best our knowledge, no research has studied either consumption pattern or perception using artificial in Saudi Arabia. Objectives Our aimed to study usage such Tabuk region estimate knowledge attitudes toward their among population. Methods A cross-sectional promoted on multiple social media platforms...
Alzheimer's disease (AD) is a chronic neurological illness that causes considerable cognitive impairment. Hepatic and renal dysfunction may worsen AD by disrupting β-amyloid homeostasis at the periphery causing metabolic dysfunction. Wheatgrass (Triticum aestivum) has been shown to have antioxidant anti-inflammatory properties. This work aims study effect of aluminum on neuronal cells, its consequences liver kidneys, possible role fluoxetine wheatgrass juice in attenuating these pathological...
Parkinson’s disease (PD) is a gradual deterioration of dopaminergic neurons, leading to motor impairments. Social isolation (SI), recognized stressor, has recently gained attention as potential influencing factor in the progress neurodegenerative illnesses. We aimed investigate intricate relationship between SI and PD progression, both independently presence manganese chloride (MnCl2), while evaluating punicalagin (PUN) therapeutic effects, natural compound established for its...
Attention deficit hyperactivity disorder (ADHD) has high incidence rate among children which may be due to excessive monosodium glutamate (MSG) consumption and social isolation (SI).We aimed explore the relationships between MSG, SI, ADHD development evaluate neuroprotective potential of Punicalagin (PUN).Eighty male rat pups randomly distributed into eight groups. Group I is control, II socially engaged rats treated with PUN. Groups III VII were exposed ADHD-inducing factors: IV V both SI...