Nephrotoxicity is defined as renal dysfunction that arises result of exposure to external agents such drugs and environmental chemicals. The present work was undertaken carry out the phytochemical study nephroprotective activity methanolic extract Casuarina equisetifolia leaves in gentamicin-induced nephrotoxicity Wistar rats. Flavonoids phenolic acids were identified quantified using high performance liquid chromatography. Subcutaneous injection rats with gentamicin (80 mg/kg body...

Summary Several chronic liver diseases can lead to the occurrence of hepatic fibrosis through accumulation iron, which causes induction oxidative stress and consequently activation fibrogenesis. The present study was designed investigate potential antifibrotic anti‐oxidant effects deferoxamine ( DFO ), a well‐known iron chelator in an experimental rat model injury using carbon tetrachloride CC l 4 ). First, effective dose screened against ‐induced acute hepatotoxicity. Then, rats were...

In the field of environmental toxicology, endocrine-disrupting effects have become a major concern. The present research set out to investigate possible reproductive toxicity acrylamide. was also expanded explore protective two nutraceuticals, thymoquinone (TQ) and capsaicin, against acrylamide-induced toxicity. Six groups sixty male albino rats were created. Group 1 used as control. Rats administered daily dose acrylamide acted model in 2. TQ provided once day 3. Capsaicin 4. given exposed...

Depression is a severely debilitating psychiatric disorder that influences more than 15% of the population worldwide. It has been demonstrated it associated with high risk developing other diseases such as cardiovascular diseases, diabetes, stroke, epilepsy, and cancer. The current study examines possibility chrysin lycopene having an antidepressant effect in rat model depression induced by clonidine, well mechanisms underlying this effect, including role neuroinflammation oxidative stress....

Alzheimer's disease (AD) is a chronic neurological illness that causes considerable cognitive impairment. Hepatic and renal dysfunction may worsen AD by disrupting β-amyloid homeostasis at the periphery causing metabolic dysfunction. Wheatgrass (Triticum aestivum) has been shown to have antioxidant anti-inflammatory properties. This work aims study effect of aluminum on neuronal cells, its consequences liver kidneys, possible role fluoxetine wheatgrass juice in attenuating these pathological...

Introduction: Liver fibrosis is the excessive accumulation of extracellular matrix (ECM) proteins including collagen that occurs in most types chronic liver diseases. This study aimed to investigate and compare therapeutic efficacy different magnesium (Mg)-containing supplements (formulations A, B, C) on carbon tetrachloride (CCl4)-induced rats. Methods: was induced by intraperitoneal injection rats with CCl4 (1:1 olive oil, 2 mL/kg, three times/week) for 4 weeks, then were orally treated...

The current research seeks to assess the anti-atherogenic activity of Egyptian artichoke leaf extract in hypercholesterolemic rats.Male albino rats were categorized into five groups; control group, high cholesterol diet treated group (HCD), HCD + low dose artichoke, and Atorvastatin.Both doses significantly decreased concentration serum cholesterol, triglycerides, LDL-C as compared that their matching controls, p < .05. treatment with led inhibition liver hydroxymethylglutaryl-CoA (HMG-CoA)...

Peptic ulcers are one of the world's major gastrointestinal disorders, embracing both gastric and duodenal ulcers, affecting 10% world population. The current study aimed to investigate possible protective effect tadalafil pentoxifylline (PTX) on indomethacin-induced peptic ulcers. Male albino rats were divided into five groups: control group; ulcerated Indomethacin + Tadalafil, in which animals pretreated with orally before indomethacin; Indomethacin+ PTX, PTX Tadafil PTX. treatment...

The aim of the current study was to examine and compare cardioprotective activities chloroform petroleum extracts leaves Casuarina suberosa in isoproterenol (ISO)-induced cardiac tissue oxidative stress. Rats were categorized into 6 groups as follows: control group, vehicle or Tween 80-treated ISO-treated extract + ISO treated ether group Reference drug (Captopril) group. injection significantly (p < 0.05) increased marker enzymes (CK-MB, LDH, ALT, AST), troponin-I, levels lipid peroxides...

Myocardial infarction (MI) continues to be a major public health problem in the world.Vanillin is natural phenolic compound that possesses significant anti-oxidant and anti-inflammatory activities.The present study aimed investigate effects of pretreatment with vanillin (150 mg/kg, p.o.) (300 on isoprenaline-induced MI rats.Markers chosen assess cardiac damage included serum activity creatine kinase-MB (CK-MB) lactate dehydrogenase (LDH), addition level troponin-I (cTn-I), as well...

Background Alzheimer’s dementia is a progressive, fatal neurodegenerative disease that manifests as disintegration of perception and memory. Objectives The current study evaluated the possible therapeutic effect coenzyme Q10 (CoQ10) and/or epigallocatechin-3-gallate (EGCG) combined with memantine on scopolamine-induced amnesia in rats by evaluating behavioral, biochemical, histopathological changes. Materials methods Rats were randomly allocated to 11 groups, each which contained 16 rats....