A5082929603- Genomics, phytochemicals, and oxidative stress
- Drug-Induced Hepatotoxicity and Protection
- Acute Kidney Injury Research
- Heavy Metal Exposure and Toxicity
- Retinoids in leukemia and cellular processes
- Cardiac Ischemia and Reperfusion
- Pharmacological Effects of Natural Compounds
- Renin-Angiotensin System Studies
- Antibiotics Pharmacokinetics and Efficacy
- Adipokines, Inflammation, and Metabolic Diseases
- Inflammatory mediators and NSAID effects
- Chemotherapy-induced organ toxicity mitigation
- Pregnancy-related medical research
- Sperm and Testicular Function
- Regulation of Appetite and Obesity
- Ginger and Zingiberaceae research
- Natural Antidiabetic Agents Studies
- Chromium effects and bioremediation
- Adipose Tissue and Metabolism
- Nuclear Receptors and Signaling
- Nitric Oxide and Endothelin Effects
- Arsenic contamination and mitigation
- Traditional Chinese Medicine Analysis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Apelin-related biomedical research
Al-Azhar University
2015-2025
Assiut University
2023-2025
Al-Azhar University
2025
Damietta University
2024
Hexavalent chromium salt, like potassium dichromate (PD), is chromium's most precarious valence state in industrial wastes. Recently, there has been increasing interest β-sitosterol (BSS), a bioactive phytosterol, as dietary supplement. BSS recommended treating cardiovascular disorders due to its antioxidant effect. Trimetazidine (TMZ) was used traditionally for cardioprotection. Through the administration of and TMZ, cardiotoxic effects PD were be countered this study, addition examining...
Nicorandil, a selective opener of potassium channels, used to treat angina, has drawn attention for its potential in mitigating lung injury, positioning it as promising therapeutic approach drug-induced toxicity. This study aimed explore the protective role nicorandil arsenic trioxide (ATO)-induced injury and elucidate underlying mechanistic pathways.
Abstract Atopic dermatitis (AD) is a persistent, inflammatory skin condition that impacts approximately 15 to 20% of children and 1 3% adults globally. Common manifestations include papules, papulovesicular, brown or red patches with swelling, crusting, flaking. Therefore, the drug abrocitinib (ABR) was approved by US FDA as an oral treatment for atopic dermatitis. The present study outlines development innovative, thermostable, pH‐stable organic solvent‐free nitrogen‐doped carbon dots...
A novel green fluorimetric approach for quantifying avapritinib in biological fluids (pharmacokinetic study).
Amikacin (AMC), an aminoglycoside antibiotic known for its rapid and potent bactericidal activity, is also associated with nephrotoxicity. Diosmin perindopril have been reported to improve renal function hold promise as therapeutic agents preventing drug-induced This study aimed investigate the protective effect of perindopril, either alone or in combination, against damage induced by AMC toxicity elucidate underlying mechanisms. The researchers evaluated impact (50 mg/kg, orally) (2...
Abstract Pre-existing diabetes raises the likelihood of Parkinson’s disease (PD), according to epidemiological and animal research. Our study aimed investigating likely neuroprotective effect metformin (Met) and/or semaglutide (Sem) in model PD male diabetic rats possible underlying mechanism. Type 2 (T2DM) was induced by giving high-fat diet (HFD) for 3 weeks followed a single streptozotocin (STZ) injection (40 mg/kg, i.p., once dose) 9 doses rotenone every 48 ± h induction PD. Met Sema...
Abstract Cardiac toxicity is a public health issue that can be caused by both environmental and occupational exposures. The current study aimed to investigate the effectiveness of carvedilol (CV), Acetovanillone (ACET), their combination for ameliorating cadmium (Cd)-induced oxidative stress, inflammation, necroptosis. Rats were assigned to; normal group, Cd group (2 mg/kg; i.p., single dose), other three groups received orally CV (10 mg/kg), ACET (25 plus ACET, respectively dose Cd. Oral...
Cardiotoxicity is a significant adverse effect of cisplatin (CIS) that necessitates extensive medical care. The current study examines the cardioprotective effects edaravone (EDV), obeticholic acid (OCA), and their combinations on CIS-induced cardiac damage. Rats were allocated into five groups: normal control group, remaining four groups received CIS (7.5 mg/kg, i.p.) as single dose fifth day assigned to CIS, OCA (10 mg/kg/day) + EDV (20 (EDV OCA) group. Compared CIS-treated co-treating...
The genus Cotula (Asteraceae) comprises about 80 species, amongst them anthemoides L. It is a wild plant growing in Egypt that possesses many traditional uses as headache, colic, and chest cold remedy. In our study, the chemical composition of C. essential oils was analyzed using GC-MS spectroscopy. Sixteen components leave stem thirteen flower were characterized. main both oil parts camphor (88.79% 86.45%) trans-thujone (5.14% 10.40%) leaves stems flowers, respectively. anti-inflammatory...
Vancomycin (VCM) is used clinically to treat serious infections caused by multi-resistant Gram-positive bacteria, although its use severely constrained nephrotoxicity. This study investigated the possible nephroprotective effect of febuxostat (FX) and/or fenofibrate (FENO) and their underlying mechanisms against VCM-induced nephrotoxicity in a rat model.
Aim: Renin-angiotensin system (RAS) is thought to have a noticeable effect in the pathophysiological injury multiple organs by inducing different cellular and molecular reactions. The objective of current study investigate possible protective effects perindopril against lipopolysaccharide (LPS)-induced cardiopulmonary oxidative inflammatory damage rats. Methods: To achieve this goal, animals were randomly divided into six groups: normal group, LPS group (3 mg/kg, i.p., single dose),...
Aims: Epidemiologic studies have shown that individuals with diabetes a higher risk of hepatic diseases which represent true clinical problem. The purpose the present study was to assess possible modulatory effect 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor lovastatin on therapeutic efficiency traditional antidiabetics, as metformin and gliclazide, regarding complications in streptozotocin (STZ)-induced rats.Methods: Animals were divided into seven groups; normal...