A5009549972- Advanced Drug Delivery Systems
- Advancements in Transdermal Drug Delivery
- Drug Solubulity and Delivery Systems
- Kidney Stones and Urolithiasis Treatments
- Inhalation and Respiratory Drug Delivery
- Urinary Bladder and Prostate Research
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Dermatology and Skin Diseases
- Probiotics and Fermented Foods
- Pediatric Urology and Nephrology Studies
- Nanoparticles: synthesis and applications
- Hedgehog Signaling Pathway Studies
- Antibiotic Resistance in Bacteria
- Bladder and Urothelial Cancer Treatments
- Oral microbiology and periodontitis research
- Asthma and respiratory diseases
- Urinary Tract Infections Management
- Advanced Nanomaterials in Catalysis
- Nonmelanoma Skin Cancer Studies
- Cancer and Skin Lesions
- Ureteral procedures and complications
- Dermatological and Skeletal Disorders
- Lipid Membrane Structure and Behavior
- Respiratory and Cough-Related Research
Sinai University
2020-2025
Beni-Suef University
2013-2024
Cooper University Health Care
2024
Cooper Medical School of Rowan University
2024
Port Said University
2023
Cairo University
2021
University College London
2014
Olanzapine (OL) is an atypical antipsychotic drug which suffers from extensive hepatic metabolism and poor bioavailability. In addition, it has low brain permeability due to efflux by P-glycoproteins. the current investigation, surface modified niosomes containing OL were prepared for targeting of through nasal route. Spans mixed with cholesterol at ratios 1:1, 1:2, 1:3, 1:4 surfactant, respectively prepare niosomes. Chitosan (CS) coated vesicles mixing optimum niosomal formula CS solution...
The present study describes glycerosomes (vesicles composed of phospholipids, glycerol and water) as a novel drug delivery system for topical application celecoxib (CLX) cupferron (CUP) compound.The goal this research was to design soft innovative vesicles loaded with CLX or CUP enhancing the efficacy avoiding systemic toxicity CUP.CLX were prepared by hydrating phospholipid-cholesterol films aqueous solutions (20-40%, v/v). Box-Behnken design, using Design-Expert® software, optimum choice...
To achieve the best treatment of skin cancer, drug penetration inside deepest layers is an important scientific interest. We designed ethosome formulation that serves as a carrier for metformin and measured in vitro permeation. also aimed to measure antitumor activity optimal ethosomal preparation when applied topically chemically induced cancer mice. utilized statistical Box–Behnken experimental design three variables at levels: lecithin concentration, cholesterol concentration mixture...
Porcine buccal mucosa is abundantly used in drug delivery studies. With the emergence of new barrier models, such as cell culture a link between these models and traditional porcine should be established. The examination was divided into two experiments: uptake different solvents an infinite dose permeation study domperidone from solvent systems through EpiOral™ tissue models; this aims to find correlation models. experiment revealed superb water by dried (>300% increase weight) high with...
The present study aimed to formulate and evaluate metformin sterosomes. Sterosomes were prepared by incorporating stearylamine cholesterol in different ratios. characterized using size, zeta potential, entrapment efficiency (EE%) vitro release. Aerosol generated nebulization was evaluated a cooled Andersen cascade impactor (ACI) at 15 L/min. In cytotoxicity of free metformin-containing sterosomes tested against human cancer cell lines. A comparative pharmacokinetic between sterosomal...
The aim of this work was to study the effect using training device (In-Check DIAL) along with traditional dry powder inhaler (DPI) counseling on inhalation technique and pulmonary functions test (PFT) in asthmatics. Adult asthmatics >18 years old were recruited 3months investigation training. They divided into control groups. DPI checked mistakes noted corrected at every monthly visit. Their peak expiratory flow forced volume 1second as percentage vital capacity each visit followed by...
The oral administration of celecoxib (CLX) is a real problem because its low aqueous solubility that results in high variability absorption and severe adverse effect such as cardiotoxic effects gastrointestinal toxicity. Self-nanoemulsifying drug delivery systems (SNEDDS) can enhance the poor dissolution erratic poorly water-soluble drugs CLX. This study was conducted to investigate potential SNEDDS efficacy CLX on inflamed mucous tissue reduce systemic by increasing properties. A...
The aim of the present study is to formulate highly permeable carriers (i.e., transethosomes) for enhancing delivery prednisolone combined with tacrolimus both topical and systemic pathological conditions. A Box-Behnken experimental design was implemented in this research. Three independent variables: surfactant concentration (X1), ethanol (X2), (X3) were adopted while three responses: entrapment efficiency (Y1), vesicle size (Y2), zeta potential (Y3) investigated. By applying analysis, one...
Background and Objectives: Fibrotic lung disease is one of the main complications many medical conditions. Therefore, use anti-fibrotic agents may provide a chance to prevent, or at least modify, such complication. The aim this study was evaluate protective pulmonary anti-inflammatory effects Dinebra retroflexa. Materials methods: retroflexa methanolic extract its synthesized silver nanoparticles were tested on bleomycin-induced fibrosis. Pulmonary fibrosis induced by intratracheal...
Objectives To compare the efficacy and safety of ultraslow full‐power versus slow rate, power‐ramping shock wave lithotripsy in management stones with a high attenuation value. Methods This was randomized comparative study enrolling patients single value (≥1000 Hounsfield unit) (≤3 cm) between September 2015 May 2018. Patients skin‐to‐stone distance >11 cm or body mass index >30 kg/m 2 were excluded. Electrohydraulic carried out at rate 30 waves/min for group A 60 B. In A, power...
Stroke ranks the fourth leading disease causing adult mortality and disability. D-dimer (D-D) is ultimate product of plasmin-mediated degradation fibrin-rich thrombi. D-D a simple readily accessible biomarker employed within diagnostic algorithms for exclusion venous thromboembolism. The correlation between infarct size in MRI brain, APACHE II score, National Institute Health Scale (NIHSS) score critically ill acute stroke patients has not been fully investigated before.We aimed to...
This review focuses on the mechanisms and methods involved in oral mucosal absorption, with a particular emphasis drug delivery systems. It begins by discussing protective role of saliva cavity, highlighting its importance maintaining health tissues facilitating delivery. The then delves into including passive diffusion, which is primary mechanism for transfer across mucosa. also explores use hydrophilic polymeric matrices as vehicles transmucosal systems, are favored due to water-rich...