A5078668913- Advanced Glycation End Products research
- Drug-Induced Hepatotoxicity and Protection
- Acute Kidney Injury Research
- Ginger and Zingiberaceae research
- Diet, Metabolism, and Disease
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Medicinal Plants and Bioactive Compounds
- Liver Disease Diagnosis and Treatment
- Natural Antidiabetic Agents Studies
- Diabetes Treatment and Management
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Alcohol Consumption and Health Effects
- Parasitic Diseases Research and Treatment
- Fatty Acid Research and Health
- Neuroscience and Neuropharmacology Research
- Cancer Diagnosis and Treatment
- MicroRNA in disease regulation
- Diet and metabolism studies
- Apelin-related biomedical research
- Phytochemistry and Biological Activities
- Pleural and Pulmonary Diseases
- Mesenchymal stem cell research
- Diverse Scientific Research Studies
- Sulfur Compounds in Biology
- Extracellular vesicles in disease
King Faisal University
2022-2025
Sinai University
2022-2025
Institute of Pharmacology
2025
Suez Canal University
2015-2019
Acute kidney injury (AKI) is a devastating consequence of sepsis, accompanied by high mortality rates. It was suggested that inflammatory pathways are closely linked to the pathogenesis lipopolysaccharide (LPS)-induced AKI. Inflammatory signaling, including PCSK9, HMGB1/RAGE/TLR4/MYD88/NF-κB, NLRP3/caspase-1 and Fractalkine/CX3CR1 considered major forerunners in this link. Alirocumab, PCSK9 inhibitor, with remarkable anti-inflammatory features. Accordingly, study aimed elucidate...
Prolonged exposure to corticosteroids (CORTs) triggers depression and anxiety symptoms either endogenously or exogenously via stimulating endoplasmic reticulum stress (ERS). The study assessed the therapeutic implications of hydrogen sulfide (H2S) versus sertraline (SERT) in alleviating induced by CORTs through modulation ERS its inflammatory, oxidative, apoptotic consequences. Rats were subdivided into four groups: control, CORT (20 mg/kg), NaHS (100 μmol/kg), SERT (10 mg/kg) for 21 days....
Insulin resistance is known to be a risk factor for cognitive impairment, most likely linked insulin signaling, microglia overactivation, and beta amyloid (Aβ) deposition in the brain. Exenatide, long lasting glucagon-like peptide-1 (GLP-1) analogue, enhances signaling shows neuroprotective properties. Pioglitazone, peroxisome proliferated-activated receptor-γ (PPAR-γ) agonist, was previously reported enhance cognition through its effect on Aβ accumulation clearance. In present study,...
Ivermectin is a US Food and Drug Administration (FDA)-approved antiparasitic agent with antiviral anti-inflammatory properties. Although recent studies reported the possible activity of ivermectin in respiratory injuries, its potential therapeutic effect on pulmonary fibrosis (PF) has not been investigated. This study aimed to explore ability (0.6 mg/kg) alleviate bleomycin-induced biochemical derangements histological changes an experimental PF rat model. can provide means validate clinical...
Multiple sclerosis (MS) is a progressive neuro-inflammatory and neuro-autoimmune disease. Although hydrogen sulfide has recently shown potential therapeutic impacts in different neurological diseases, its effects on MS are still obscure. MiR-146a considered vital target for approaches treating MS. The present study directed to explore the of NaHS (hydrogen donor) cuprizone-induced whether can mediate via regulating miR-146a expression. A total 28 male C57Bl/6 mice were divided into 4 groups;...
Background and Objectives: Fibrotic lung disease is one of the main complications many medical conditions. Therefore, use anti-fibrotic agents may provide a chance to prevent, or at least modify, such complication. The aim this study was evaluate protective pulmonary anti-inflammatory effects Dinebra retroflexa. Materials methods: retroflexa methanolic extract its synthesized silver nanoparticles were tested on bleomycin-induced fibrosis. Pulmonary fibrosis induced by intratracheal...
Background Hypertension is a prevalent chronic disorder that affects approximately 1.28 billion adults worldwide. In the use of amlodipine, though it cost-effective antihypertensive agent, causes side effect may lead to discontinuation medication. Purpose To examine combination Elettaria cardamomum plus low dose amlodipine on N ω -nitro-l-arginine methyl ester (L-NAME)-induced hypertensive rat model. Materials and Methods Thirty adult male Wistar rats were randomized into five groups six...