A5057927941- Pain Mechanisms and Treatments
- Cannabis and Cannabinoid Research
- Ion Channels and Receptors
- Chemotherapy-induced organ toxicity mitigation
- Liver Disease Diagnosis and Treatment
- Adenosine and Purinergic Signaling
- Cancer, Lipids, and Metabolism
- Urticaria and Related Conditions
- Neurotransmitter Receptor Influence on Behavior
- Eicosanoids and Hypertension Pharmacology
- Diet and metabolism studies
- Pharmacology and Obesity Treatment
- Inflammatory mediators and NSAID effects
- Genomics, phytochemicals, and oxidative stress
- Sesame and Sesamin Research
- Botulinum Toxin and Related Neurological Disorders
- Forensic Toxicology and Drug Analysis
- Apelin-related biomedical research
- Mesenchymal stem cell research
- Cancer, Hypoxia, and Metabolism
- Advanced Chemical Sensor Technologies
- Aluminum toxicity and tolerance in plants and animals
- Nicotinic Acetylcholine Receptors Study
- Pancreatic and Hepatic Oncology Research
- MicroRNA in disease regulation
King Faisal University
2018-2025
University of Jordan
2023
University of Dundee
2023
King Fahad Specialist Hospital
2023
Cisplatin is a chemotherapeutic drug that has been used in the treatment of various types human cancers such as ovarian, lung, head and neck, testicular bladder. demonstrated efficacy against germ cell tumors, sarcomas, carcinomas well lymphomas. The current study presents pharmacological review on including its mechanism action, resistance mechanism, toxicity clinical applications. action cisplatin associated with ability to crosslink urine bases DNA form adducts, preventing repair leading...
The present work was undertaken to study the effects of transcutaneous auricular vagus nerve stimulation (taVNS) on 1, 2-dimethyhydrazine (DMH) induced colon cancer and role cholinergic anti-inflammatory pathways (CAP) in same. Groups rats were randomly divided into ten groups (
A major problem with current animal models of pain is their lack face validity and vulnerability for false positive results. The present study evaluated the efficacy open field locomotor system, as an objective measure pain‑related behavior analgesic in rodents. Adult, male, Sprague‑Dawley rats (180‑250 g) received intra‑articular injections monoiodoacetate (MIA; 1 mg) left knee joint. Mechanical allodynia using von Frey filaments, weight bearing difference test activity were performed every...
Neuropathic pain is a growing healthcare problem causing global burden. Currently used analgesics such as opioids are associated with adverse effects; urging the need for safer alternatives. Here we aimed to investigate potential analgesic effects of tesaglitazar; dual peroxisome proliferator-activated receptors α and γ (PPAR ) agonist in rat models neuropathic pain. This study also modulation transient receptor vanilloid 1 (TRPV1) activity by tesaglitazar which could provide mechanism that...
Chronic pain is a persistent and debilitating health problem. Although the use of analgesics such as opioids useful in mitigating pain, their prolonged associated with unwanted effects including abuse liability. This study assesses antinociceptive effect combining subtherapeutic doses two (morphine or tramadol) synthetic cannabinoid CP55940 (2-[(1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]-5-(2-methyloctan -2-yl)phenol). It also evaluates adverse these drugs combinations. Adult male...
Palmitoylethanolamine (PEA) is a ligand at peroxisome proliferator-activated receptors-α (PPARα), nuclear receptor that has anti-inflammatory effects. Herein, complete Freund's adjuvant (CFA)-induced inflammatory pain model in rats and in-vitro calcium imaging studies were used to evaluate the mechanisms underlie antinociceptive effects of PEA, including modulating activity transient potential vanilloid 1, which key involved development pain. Adult male Sprague-Dawley (180-250 g) received...
Abstract Transient receptor potential vanilloid type‐1 (TRPV1) channels play key roles in chronic pain conditions and are modulated by different inflammatory mediators to elicit heat sensitisation. Bradykinin is a 9‐amino acid peptide chain that promotes inflammation. The aim of present study investigate how bradykinin prostaglandin receptors (EP 3 EP 4 ) modulate the sensitisation TRPV1‐mediated responses. Calcium imaging studies rat dorsal root ganglion (DRG) neurons were employed...
One of the well-studied phase II drug metabolizing enzymes is N-acetyltransferase 2 ( NAT2 ) which has an essential role in detoxification and metabolism several environmental toxicants many therapeutic drugs like isoniazid (antituberculosis, TB) antimicrobial sulfonamides. According to variability acetylation rate among different ethnic groups, individuals could be classified into slow, intermediate, fast acetylators; these variabilities are a result single nucleotide polymorphisms (SNPs)...
Hematopoietic stem cells (HPSCs) are multipotent that can differentiate into lymphoid and myeloid progenitors, giving rise to white blood (WBCs), red (RBCs), platelets. HPSCs a widely used treatment for many hematological non-malignant malignant disorders. be in the fresh or cryopreserved state future use. Fresh typically stored at 2-6°C up 72 hours primarily allogeneic transplants autologous myeloma lymphoma patients. However, some cases of donations, HPSC transplantation is delayed more...
Transient receptor potential vanilloid type-1 (TRPV1) channels have crucial roles in inflammatory hyperalgesia. Different mediators can modulate TRPV1 sensitization. Bradykinin is an algogenic substance released at the site of inflammation. The aim present study to investigate desensitization by nonpungent agonists and determine how bradykinin prostaglandin E2 receptors (EP 3 EP 4 ) resensitization after being desensitized agonists. Tail flick test was used capsaicin-induced thermal...
Extracts of the deadly nightshade plant, Atropa belladonna, contain a naturally occurring amine, Atropine, which is isolated from belladonna and other plants (Solanaceae). The are used for making wide range drugs. Drug absorption via mucosal membrane stomach extremely low because acid gastric contents. Atropine prescription pharmaceutical to treat symptoms decreased heart rate (bradycardia). also suppress salivation bronchial secretions before surgery. can be on its own or in combination...
The main objective of the current study was to investigate in vitro and vivo antidiabetic activity methanol extracts Carthamus oxyacantha leaves corollas. In assays such as inhibition α-amylase enzyme, non-enzymatic glycosylation hemoglobin glucose uptake yeast cells were carried out. results assay revealed that IC50 leaf corolla almost same (58.5 57.1 µg/ml, respectively) when compared with positive control acarbose (45.3 µg/ml). Glycosylation inhibited extract showed an value 61.7...
Purpose: The aim of his study is to examine the effect using cannabidiol upon gastric ulcer induced by diclofenac in rats. Method: experiment was conducted on four groups, with normal rats serving as a control group one. A single oral dose administered Group 2 order induce stomach ulcer. third were given dosage sodium, followed 5-day therapy cannabidiol, which began three days before administration. Drug cannabidiol-treated final (Group 4). Results: investigation showed that when...
Transient receptor potential vanilloid type-1 (TRPV1) channels play key roles in chronic pain conditions and are modulated by different inflammatory mediators to elicit heat sensitisation. Bradykinin is a 9-amino acid peptide chain that promotes inflammation. The aim of present study investigate how bradykinin prostaglandin receptors (EP3 EP4) modulate the sensitisation TRPV1-mediated responses. Calcium imaging studies rat dorsal root ganglion (DRG) neurons were employed desensitizing...
The main aim of the study includes analyzing protective effects sesamol testicular in arsenic-induced toxicity. Primarily there have been different treatments and sample preparation methods that includethe mixing drugs seasonal arsenic, as they were immersed into aqueous solution tween 80 further arsenic stabilisation was done using gum 0.2%. A total four groups, each group having 8 rats selected. Testicular catalase is decreased treated whereas (Glutathione synthetase) GSH, (nitric oxide)...