The study is aimed at exploring the popularity, impact, and usefulness of using YouTube in learning anatomy as perceived by Jordanian medical students studying Jordan University Science Technology.The present work a cross-sectional questionnaire-based study. First-, second-, third-year were invited to complete an anonymous questionnaire. Students' responses numerically coded, results analyzed reveal any statistically significant differences related gender or level study.The showed that 96.4%...

Insomnia is a problem that common in all societies and age groups. However, its importance increasing between students especially with the highly competitive demanding environment surrounding them even after their graduation. In spite of deep understanding health social consequences, frequency insomnia among medical Jordan was not determined.To determine prevalence sleep disturbances college to look for any association students' academic achievement.This cross-sectional self-administered...

We examined expression of protease-activated receptors 2 (PAR2) and characterized their signaling pathways in rabbit gastric muscle cells. The PAR2 activating peptide SLIGRL (PAR2-AP) stimulated Gq, G13, Gi1, PI hydrolysis, Rho kinase activity, inhibited cAMP formation. Stimulation hydrolysis was partly cells expressing siRNA, Gaq or Gai minigene treated with pertussis toxin, augmented by dominant negative regulator G protein (RGS4(N88S)). activity abolished PAR-2 Ga13 minigene. PAR2-AP...

This study was conducted to identify the morphometric features of hard palate and test reliability using palatal morphology in sex determination. Three hundred maxillary casts were collected from dental clinics north Jordan. The age gender patient serial number for each cast recorded. range 6 50 years old. A caliper used perform following measurements: length, width, depth palate. In addition, size, shape, position incisive papilla also determined. All measurements done by a trained examiner...

Various gastrointestinal (GI) disorders have a higher prevalence in women than men. In addition, estrogen has been demonstrated to an inhibitory effect on the contractility of GI smooth muscle. Although increased plasma levels implicated disorders, role gastric receptor (ER) these sex‑specific differences remains be fully elucidated. The present study was designed investigate sex‑associated expression two ER isoforms, ERα and ERβ, muscle contraction via nitric oxide (NO)/cyclic guanosine...

Intestinal smooth muscle cells (SMCs) undergo substantial morphological, phenotypic, and contractile changes during inflammatory bowel disease (IBD). SMCs act as a source target for different mediators, however their role in IBD pathogenesis is usually overlooked. Glucagon-like peptide-1 (GLP-1) an incretin hormone reported to exert multiple anti-inflammatory effects tissues including the gastrointestinal tract through various mechanisms.The aim of this research explore effect GLP-1 analog...

Recent studies have identified AMP-activated kinase (AMPK) as a target of Ca²⁺/calmodulin-dependent (CaMKK<i>β</i>) and negative regulator myosin light-chain (MLC) (MLCK). The present study examined whether change in expression or activity AMPK is responsible for hypercontractility intestinal longitudinal muscle during inflammation response to proinflammatory cytokines. In mouse colonic cells, acetylcholine (ACh) stimulated MLCK phosphorylation induced MLC₂₀...

Type 2 diabetes mellitus (T2DM) is a leading cause of death. The prevalence T2DM in countries the Middle East and North Africa (MENA) region, including Jordan, among highest worldwide. reason(s) behind epidemic nature Jordan are unknown but warrant further exploration. Studies have indicated that could be influenced by diet and/or genetic background. Evidence suggests numerous patients with deficient vitamin D. activity D on its target tissues may single nucleotide polymorphisms (SNPs)...

Transglutaminase (TG) isoforms control diverse normal and pathophysiologic processes through their capacity to cross-link extracellular matrix (ECM) proteins. Their functional signalling roles in cardiac fibrosis remain poorly understood, despite some evidence of TG2 involvement abnormal ECM remodelling heart diseases. In this study, we investigated the role TG1 mediating fibrotic signalling, collagen cross-linking, cell proliferation healthy fibroblasts by siRNA-mediated knockdown. siRNA...

Caveolae act as scaffolding proteins for several G protein-coupled receptor signaling molecules to regulate their activity. Caveolin-1, the predominant isoform in smooth muscle, drives formation of caveolae. The precise role caveolin-1 and caveolae scaffolds contraction gastrointestinal muscle is unclear. Thus aim this study was examine regulation q - i -coupled signaling. RT-PCR, Western blot, radioligand-binding studies demonstrated selective expression M 2 3 receptors gastric cells....

Peroxynitrite is a reactive nitrogen species produced in the intravascular compartment from superoxide anion and nitric oxide. destroys blood plasma proteins membranes of red cells platelets. This explains why excessive production peroxynitrite contributes to diseases ageing. Therapeutics that antagonize may delay ageing progression disease. We developed an vitro assay allows investigation oxidative damage caused by compartment. correlates with rate formation protein carbonyl groups,...

Type 2 diabetes mellitus (T2DM) is a worldwide health problem caused by resistance to insulin action. This chronic debilitating diseaseis preceded stage, known as prediabetes, in which healthy lifestyle can delay the disease. The discovery of biochemical changes prediabetes important identify individuals at risk developing T2DM and explaining disease pathogenesis. Adiponectin secreted fat cells linked with resistance. levels are dysregulated prediabetic subjects. relationship had not been...

Gender-related differences in various gastric functions and diseases have been reported, with women having a higher prevalence of gastrointestinal disturbances than men. The aim this study was to investigate sex-dependent activation the Rho-associated protein kinase (ROCK; RhoA/Rho kinase) pathway muscle contraction stomach using single smooth cells (GSMC) from male female Sprague-Dawley rats. Expression ROCK1 ROCK2 acetylcholine (ACh)-induced RhoA ROCK were measured specifically designed...

Palmitoylethanolamine (PEA) is a ligand at peroxisome proliferator-activated receptors-α (PPARα), nuclear receptor that has anti-inflammatory effects. Herein, complete Freund's adjuvant (CFA)-induced inflammatory pain model in rats and in-vitro calcium imaging studies were used to evaluate the mechanisms underlie antinociceptive effects of PEA, including modulating activity transient potential vanilloid 1, which key involved development pain. Adult male Sprague-Dawley (180-250 g) received...

Neurotrophins are present in the gastrointestinal tract where they participate survival and growth of enteric neurons, augmentation circuits, elevation colonic myoelectrical activity also different aspects colitis. Previous studies largely focused on role neural mucosal neurotrophins gut inflammation. The expression smooth muscle cells (SMCs) interactions this potential source with colitis has not been studied gut. NGF, BDNF, NT-3 NT-4 SMCs from longitudinal circular layers rat colon normal...

The prevalence of type 2 diabetes mellitus (T2DM) is steadily increasing worldwide in an alarming fashion. Importantly, poor glycemic control associated with development various health sequalae's due to glucolipotoxicity, oxidative stress and increased inflammatory cytokines. aim the present study was examine effect on relative abundance markers patients controlled uncontrolled T2DM, test their association status diabetic Jordan. An observational cross-sectional design used. Patients T2DM...

Lipid peroxidation is associated with several metabolic diseases. causes cellular damage through reactive aldehyde species such as 4-hydroxyonenal (4-HNE). The exact mechanism(s) by which 4-HNE in the intravascular compartment not yet exactly understood. Using an vitro system, induced on blood was investigated measuring protein carbonyl groups and thiobarbituric acid substances (TBARS) following treatment. findings demonstrated that treatment increased carbonylation of formation TBARS...