A5079299054- Atrial Fibrillation Management and Outcomes
- Pulmonary Hypertension Research and Treatments
- Eicosanoids and Hypertension Pharmacology
- Cardiac Arrhythmias and Treatments
- Cardiovascular Effects of Exercise
- Cardiac electrophysiology and arrhythmias
- Cardiac Fibrosis and Remodeling
- Fatty Acid Research and Health
- Cardiovascular Disease and Adiposity
- Cardiovascular Function and Risk Factors
- Atherosclerosis and Cardiovascular Diseases
- Blood properties and coagulation
- Ion channel regulation and function
- Pesticide Exposure and Toxicity
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- S100 Proteins and Annexins
- Tendon Structure and Treatment
- Advanced Glycation End Products research
- Inflammasome and immune disorders
- IL-33, ST2, and ILC Pathways
- Cardiac Ischemia and Reperfusion
- Occupational exposure and asthma
- Climate Change and Health Impacts
- Cholesterol and Lipid Metabolism
- Telomeres, Telomerase, and Senescence
Université de Montréal
2019-2025
Montreal Heart Institute
2020-2025
Wuhan University
2024
McGill University
2024
Renmin Hospital of Wuhan University
2024
Université de Sherbrooke
2014-2016
Institut Universitaire de Cardiologie et de Pneumologie de Québec
2015
Abstract Aims Inflammation plays a role in atrial fibrillation (AF), but classical anti-inflammatory molecules are ineffective. Recent evidence suggests that failure of inflammation-resolution causes persistent inflammatory signalling and novel drug-family called resolvins promotes inflammation-resolution. Right heart disease (RHD) is associated with AF; experimental RHD shows signs inflammatory-pathway activation. Here, we evaluated resolvin-therapy effects on arrhythmogenic remodelling...
Malignant ventricular arrhythmia (VA) is a major contributor to sudden cardiac death (SCD) in patients with pulmonary arterial hypertension (PAH)-induced right heart failure (RHF). Recently, dapagliflozin (DAPA), sodium/glucose cotransporter-2 inhibitor (SGLT2i), has been found exhibit cardioprotective effects left systolic dysfunction. In this study, we examined the of DAPA on VA vulnerability rat model PAH-induced RHF.Rats randomly received monocrotaline (MCT, 60 mg/kg) or vehicle via...
Abstract Aims Cellular senescence is a stress-related or aging response believed to contribute many cardiac conditions; however, its role in atrial fibrillation (AF) unknown. Age the single most important determinant of risk AF. The present study was designed (i) evaluate AF susceptibility and marker expression rat models myocardial infarction (MI), (ii) effect reducing senescent-cell burden with senolytic therapy on substrate MI rats, (iii) assess markers human tissue as function age...
n-3 Polyunsaturated fatty acids (n-3 PUFA) have been shown to reduce inflammation and proliferation of pulmonary artery smooth muscle cells under pathophysiological conditions. However, the anti-inflammatory effect newly synthesized docosapentaenoic acid monoacylglyceride (MAG-DPA) on key signaling pathways in hypertension (PH) pathogenesis has yet be assessed. The aim present study was determine effects MAG-DPA remodeling occurring a rat model PH, induced by single injection monocrotaline...
Atrial fibrillation (AF) is the most common cardiac arrhythmia. AF can lead to severe complications, including stroke, myocardial infarction, and sudden death. risk factors include pathological aging conditions such as obesity, diabetes, hypertension. Clinical data revealed that cardiothoracic non-cardiothoracic surgeries are also important for AF. Post-operative (POAF) associated with public health costs caused by increased hospitalization, frequent emergency room visits, enhanced...
Pulmonary hypertension (PH) is a rare disease in which pathophysiology characterized by an increase proinflammatory mediators, chronic endothelial dysfunctions, and high migration rate of smooth muscle cells (SMC). Over the course last decade, various treatments have been proposed to relax pulmonary arteries, none effective resolving PH. Our hypothesis that artery-relaxing drugs are not long-term solution, but rather inhibition tissue inflammation, underlies human artery (HPA) dysfunctions...
Abstract Aims Recent studies suggest that bioactive mediators called resolvins promote an active resolution of inflammation. Inflammatory signalling is involved in the development substrate for atrial fibrillation (AF). The aim this study to evaluate effects resolvin-D1 on arrhythmogenic remodelling resulting from left ventricular (LV) dysfunction induced by myocardial infarction (MI) rats. Methods and results MI was produced anterior descending coronary artery ligation. Intervention groups...
Abstract Aims Right heart disease (RHD), characterized by right ventricular (RV) and atrial (RA) hypertrophy, cardiomyocytes’ (CM) dysfunctions have been described to be associated with the incidence of fibrillation (AF). AF in common, an inflammatory status, but mechanisms relating RHD, inflammation, remain unclear. We hypothesized that generates electrophysiological morphological remodelling affecting CM, leading inflammation increased susceptibility. Methods results Pulmonary artery...
No studies have assessed the specific contributions of atrial fibrillation (AF)-related vs. associated ventricular arrhythmia to remodelling. This study roles high rate in AF-associated remodelling.Four primary dog-groups (12/group) were subjected 3-week pacing: 600-b.p.m. tachypacing maintaining AF [AF w/o- atrioventricular block (AVB)]; with atrioventricular-node ablation (AF+AVB) and ventricular-demand pacing (80 b.p.m.); 160-b.p.m. ventricular-tachypacing (V160) reproducing response...
Pulmonary hypertension (PH) is a rare and progressive disease characterized by an inflammatory status vessel wall remodeling, resulting in increased pulmonary artery resistance. During the last decade, treatments have been proposed; most of them target endothelial pathways that stimulate smooth muscle cell relaxation. However, PH remains associated with significant morbidity. We hypothesized inflammation plays crucial role severity abnormal vasoconstriction PH. The goal this study was to...
Transglutaminase (TG) isoforms control diverse normal and pathophysiologic processes through their capacity to cross-link extracellular matrix (ECM) proteins. Their functional signalling roles in cardiac fibrosis remain poorly understood, despite some evidence of TG2 involvement abnormal ECM remodelling heart diseases. In this study, we investigated the role TG1 mediating fibrotic signalling, collagen cross-linking, cell proliferation healthy fibroblasts by siRNA-mediated knockdown. siRNA...