A5072185971- Cardiovascular Function and Risk Factors
- Cardiac Fibrosis and Remodeling
- Ion channel regulation and function
- Cardiac electrophysiology and arrhythmias
- Fuel Cells and Related Materials
- Cardiovascular Effects of Exercise
- Cardiac Ischemia and Reperfusion
- Cardiac Imaging and Diagnostics
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
Wuhan University
2022-2025
Renmin Hospital of Wuhan University
2023-2025
Malignant ventricular arrhythmia (VA) is a major contributor to sudden cardiac death (SCD) in patients with pulmonary arterial hypertension (PAH)-induced right heart failure (RHF). Recently, dapagliflozin (DAPA), sodium/glucose cotransporter-2 inhibitor (SGLT2i), has been found exhibit cardioprotective effects left systolic dysfunction. In this study, we examined the of DAPA on VA vulnerability rat model PAH-induced RHF.Rats randomly received monocrotaline (MCT, 60 mg/kg) or vehicle via...
Enhanced cardiac sympathetic activity contributes to chronic heart failure (CHF). Interventions targeting the stellate ganglion (SG) can reduce this activity, potentially slowing progression of cardiovascular diseases. This study examined effects and mechanisms ganglionectomy on myocardial hypertrophy dysfunction caused by pressure overload. A rat model overload was created using abdominal aortic constriction. Four groups were studied: sham surgery, coarctation (AB), constriction plus left...
Abstract This study mainly explored the effect and mechanism of Src homology 2 (SH2) B adaptor protein 1 (SH2B1) on cardiac glucose metabolism during pressure overload‐induced hypertrophy dysfunction. A pressure‐overloaded model was constructed, SH2B1‐siRNA injected through tail vein. Haematoxylin eosin (H&E) staining used to detect myocardial morphology. ANP, BNP, β‐MHC diameter fibres were quantitatively measured evaluate degree hypertrophy, respectively. GLUT1 , GLUT4 IR detected...